Despite major advances in artificial intelligence (AI) for medicine and healthcare, the deployment and adoption of AI technologies remain limited in real-world clinical practice. In recent years, concerns have been raised about the technical, clinical, ethical and legal risks associated with medical AI. To increase real world adoption, it is essential that medical AI tools are trusted and accepted by patients, clinicians, health organisations and authorities. This work describes the FUTURE-AI guideline as the first international consensus framework for guiding the development and deployment of trustworthy AI tools in healthcare. The FUTURE-AI consortium was founded in 2021 and currently comprises 118 inter-disciplinary experts from 51 countries representing all continents, including AI scientists, clinicians, ethicists, and social scientists. Over a two-year period, the consortium defined guiding principles and best practices for trustworthy AI through an iterative process comprising an in-depth literature review, a modified Delphi survey, and online consensus meetings. The FUTURE-AI framework was established based on 6 guiding principles for trustworthy AI in healthcare, i.e. Fairness, Universality, Traceability, Usability, Robustness and Explainability. Through consensus, a set of 28 best practices were defined, addressing technical, clinical, legal and socio-ethical dimensions. The recommendations cover the entire lifecycle of medical AI, from design, development and validation to regulation, deployment, and monitoring. FUTURE-AI is a risk-informed, assumption-free guideline which provides a structured approach for constructing medical AI tools that will be trusted, deployed and adopted in real-world practice. Researchers are encouraged to take the recommendations into account in proof-of-concept stages to facilitate future translation towards clinical practice of medical AI.

Federated Learning (FL) is a novel approach enabling several clients holding sensitive data to collaboratively train machine learning models, without centralizing data. The cross-silo FL setting corresponds to the case of few ($2$--$50$) reliable clients, each holding medium to large datasets, and is typically found in applications such as healthcare, finance, or industry. While previous works have proposed representative datasets for cross-device FL, few realistic healthcare cross-silo FL datasets exist, thereby slowing algorithmic research in this critical application. In this work, we propose a novel cross-silo dataset suite focused on healthcare, FLamby (Federated Learning AMple Benchmark of Your cross-silo strategies), to bridge the gap between theory and practice of cross-silo FL. FLamby encompasses 7 healthcare datasets with natural splits, covering multiple tasks, modalities, and data volumes, each accompanied with baseline training code. As an illustration, we additionally benchmark standard FL algorithms on all datasets. Our flexible and modular suite allows researchers to easily download datasets, reproduce results and re-use the different components for their research. FLamby is available at~\url{www.github.com/owkin/flamby}.

Federated learning (FL) has been a promising approach in the field of medical imaging in recent years. A critical problem in FL, specifically in medical scenarios is to have a more accurate shared model which is robust to noisy and out-of distribution clients. In this work, we tackle the problem of statistical heterogeneity in data for FL which is highly plausible in medical data where for example the data comes from different sites with different scanner settings. We propose IDA (Inverse Distance Aggregation), a novel adaptive weighting approach for clients based on meta-information which handles unbalanced and non-iid data. We extensively analyze and evaluate our method against the well-known FL approach, Federated Averaging as a baseline. Keywords: Deep Learning · Federated Learning · Distributed Learning · Privacy-preserving.

Organ segmentation is an important pre-processing step in many computer assisted intervention and computer assisted diagnosis methods. In recent years, CNNs have dominated the state of the art in this task. Organ segmentation scenarios present a challenging environment for these methods due to high variability in shape, similarity with background, etc. This leads to the generation of false negative and false positive regions in the output segmentation. In this context, the uncertainty analysis of the model can provide us with useful information about potentially misclassified elements. In this work we propose a method based on uncertainty analysis and graph convolutional networks as a post-processing step for segmentation. For this, we employ the uncertainty levels of the CNN to formulate a semi-supervised graph learning problem that is solved by training a GCN on the low uncertainty elements. Finally, we evaluate the full graph on the trained GCN to get the refined segmentation. We compare our framework with CRF on a graph-like data representation as refinement strategy.

Recently, Geometric Deep Learning (GDL) has been introduced as a novel and versatile framework for computer-aided disease classification. GDL uses patient meta-information such as age and gender to model patient cohort relations in a graph structure. Concepts from graph signal processing are leveraged to learn the optimal mapping of multi-modal features, e.g. from images to disease classes. Related studies so far have considered image features that are extracted in a pre-processing step. We hypothesize that such an approach prevents the network from optimizing feature representations towards achieving the best performance in the graph network. We propose a new network architecture that exploits an inductive end-to-end learning approach for disease classification, where filters from both the CNN and the graph are trained jointly. We validate this architecture against state-of-the-art inductive graph networks and demonstrate significantly improved classification scores on a modified MNIST toy dataset, as well as comparable classification results with higher stability on a chest X-ray image dataset. Additionally, we explain how the structural information of the graph affects both the image filters and the feature learning.

Learning Interpretable representation in medical applications is becoming essential for adopting data-driven models into clinical practice. It has been recently shown that learning a disentangled feature representation is important for a more compact and explainable representation of the data. In this paper, we introduce a novel adversarial variational autoencoder with a total correlation constraint to enforce independence on the latent representation while preserving the reconstruction fidelity. Our proposed method is validated on a publicly available dataset showing that the learned disentangled representation is not only interpretable, but also superior to the state-of-the-art methods. We report a relative improvement of 81.50% in terms of disentanglement, 11.60% in clustering, and 2% in supervised classification with a few amounts of labeled data.

Geometric deep learning provides a principled and versatile manner for the integration of imaging and non-imaging modalities in the medical domain. Graph Convolutional Networks (GCNs) in particular have been explored on a wide variety of problems such as disease prediction, segmentation, and matrix completion by leveraging large, multimodal datasets. In this paper, we introduce a new spectral domain architecture for deep learning on graphs for disease prediction. The novelty lies in defining geometric 'inception modules' which are capable of capturing intra- and inter-graph structural heterogeneity during convolutions. We design filters with different kernel sizes to build our architecture. We show our disease prediction results on two publicly available datasets. Further, we provide insights on the behaviour of regular GCNs and our proposed model under varying input scenarios on simulated data.

Learning from a few examples is a key characteristic of human intelligence that AI researchers have been excited about modeling. With the web-scale data being mostly unlabeled, few recent works showed that few-shot learning performance can be significantly improved with access to unlabeled data, known as semi-supervised few shot learning (SS-FSL). We introduce a SS-FSL approach that we denote as Consistent Prototypical Networks (CPN), which builds on top of Prototypical Networks. We propose new loss terms to leverage unlabelled data, by enforcing notions of local and global consistency. Our work shows the effectiveness of our consistency losses in semi-supervised few shot setting. Our model outperforms the state-of-the-art in most benchmarks, showing large improvements in some cases. For example, in one mini-Imagenet 5-shot classification task, we obtain 70.1% accuracy to the 64.59% state-of-the-art. Moreover, our semi-supervised model, trained with 40% of the labels, compares well against the vanilla prototypical network trained on 100% of the labels, even outperforming it in the 1-shot mini-Imagenet case with 51.03% to 49.4% accuracy. For reproducibility, we make our code publicly available.

SELF-A TTENTION EQUIPPED GRAPH CONVOLUTIONS FOR DISEASE PREDICTION Anees Kazi 1, S.Arvind krishna 2, Shayan Shekarforoush 3, Karsten Kortuem 4, Shadi Albarqouni 1, Nassir Navab 1, 5 1 Computer Aided Medical Procedures, Technische Universität München, Germany 2 National Institute of Technology Tiruchirappalli, India 3 Sharif University of Technology, Iran 4 Augenklinik der Universität, Klinikum der Universität München, Germany 5 Johns Hopkins University, Baltimore MD, USA ABSTRACT Multi-modal data comprising imaging (MRI, fMRI, PET, etc.) and non-imaging (clinical test, demographics, etc.) data can be collected together and used for disease prediction. Such diverse data gives complementary information about the patient's condition to make an informed diagnosis. A model capable of leveraging the individuality of each multi-modal data is required for better disease prediction. We propose a graph convolution based deep model which takes into account the distinctiveness of each element of the multi-modal data. We incorporate a novel self-attention layer, which weights every element of the demographic data by exploring its relation to the underlying disease.

Generative Adversarial Networks (GANs) and their extensions have carved open many exciting ways to tackle well known and challenging medical image analysis problems such as medical image denoising, reconstruction, segmentation, data simulation, detection or classification. Furthermore, their ability to synthesize images at unprecedented levels of realism also gives hope that the chronic scarcity of labeled data in the medical field can be resolved with the help of these generative models. In this review paper, a broad overview of recent literature on GANs for medical applications is given, the shortcomings and opportunities of the proposed methods are thoroughly discussed and potential future work is elaborated. A total of 63 papers published until end of July 2018 are reviewed. For quick access, the papers and important details such as the underlying method, datasets and performance are summarized in tables.