Importance: Emergency department (ED) returns for mental health conditions pose a major healthcare burden, with 24-27% of patients returning within 30 days. Traditional machine learning models for predicting these returns often lack interpretability for clinical use. Objective: To assess whether integrating large language models (LLMs) with machine learning improves predictive accuracy and clinical interpretability of ED mental health return risk models. Methods: This retrospective cohort study analyzed 42,464 ED visits for 27,904 unique mental health patients at an academic medical center in the Deep South from January 2018 to December 2022. Main Outcomes and Measures: Two primary outcomes were evaluated: (1) 30-day ED return prediction accuracy and (2) model interpretability using a novel LLM-enhanced framework integrating SHAP (SHapley Additive exPlanations) values with clinical knowledge. Results: For chief complaint classification, LLaMA 3 (8B) with 10-shot learning outperformed traditional models (accuracy: 0.882, F1-score: 0.86). In SDoH classification, LLM-based models achieved 0.95 accuracy and 0.96 F1-score, with Alcohol, Tobacco, and Substance Abuse performing best (F1: 0.96-0.89), while Exercise and Home Environment showed lower performance (F1: 0.70-0.67). The LLM-based interpretability framework achieved 99% accuracy in translating model predictions into clinically relevant explanations. LLM-extracted features improved XGBoost AUC from 0.74 to 0.76 and AUC-PR from 0.58 to 0.61. Conclusions and Relevance: Integrating LLMs with machine learning models yielded modest but consistent accuracy gains while significantly enhancing interpretability through automated, clinically relevant explanations. This approach provides a framework for translating predictive analytics into actionable clinical insights.

Substance use disorders (SUDs) are a growing concern globally, necessitating enhanced understanding of the problem and its trends through data-driven research. Social media are unique and important sources of information about SUDs, particularly since the data in such sources are often generated by people with lived experiences. In this paper, we introduce Reddit-Impacts, a challenging Named Entity Recognition (NER) dataset curated from subreddits dedicated to discussions on prescription and illicit opioids, as well as medications for opioid use disorder. The dataset specifically concentrates on the lesser-studied, yet critically important, aspects of substance use--its clinical and social impacts. We collected data from chosen subreddits using the publicly available Application Programming Interface for Reddit. We manually annotated text spans representing clinical and social impacts reported by people who also reported personal nonmedical use of substances including but not limited to opioids, stimulants and benzodiazepines. Our objective is to create a resource that can enable the development of systems that can automatically detect clinical and social impacts of substance use from text-based social media data. The successful development of such systems may enable us to better understand how nonmedical use of substances affects individual health and societal dynamics, aiding the development of effective public health strategies. In addition to creating the annotated data set, we applied several machine learning models to establish baseline performances. Specifically, we experimented with transformer models like BERT, and RoBERTa, one few-shot learning model DANN by leveraging the full training dataset, and GPT-3.5 by using one-shot learning, for automatic NER of clinical and social impacts. The dataset has been made available through the 2024 SMM4H shared tasks.

Large language models (LLMs) have demonstrated remarkable success in NLP tasks. However, there is a paucity of studies that attempt to evaluate their performances on social media-based health-related natural language processing tasks, which have traditionally been difficult to achieve high scores in. We benchmarked one supervised classic machine learning model based on Support Vector Machines (SVMs), three supervised pretrained language models (PLMs) based on RoBERTa, BERTweet, and SocBERT, and two LLM based classifiers (GPT3.5 and GPT4), across 6 text classification tasks. We developed three approaches for leveraging LLMs for text classification: employing LLMs as zero-shot classifiers, us-ing LLMs as annotators to annotate training data for supervised classifiers, and utilizing LLMs with few-shot examples for augmentation of manually annotated data. Our comprehensive experiments demonstrate that employ-ing data augmentation using LLMs (GPT-4) with relatively small human-annotated data to train lightweight supervised classification models achieves superior results compared to training with human-annotated data alone. Supervised learners also outperform GPT-4 and GPT-3.5 in zero-shot settings. By leveraging this data augmentation strategy, we can harness the power of LLMs to develop smaller, more effective domain-specific NLP models. LLM-annotated data without human guidance for training light-weight supervised classification models is an ineffective strategy. However, LLM, as a zero-shot classifier, shows promise in excluding false negatives and potentially reducing the human effort required for data annotation. Future investigations are imperative to explore optimal training data sizes and the optimal amounts of augmented data.

The Internet of Medical Things (IoMT) transcends traditional medical boundaries, enabling a transition from reactive treatment to proactive prevention. This innovative method revolutionizes healthcare by facilitating early disease detection and tailored care, particularly in chronic disease management, where IoMT automates treatments based on real-time health data collection. Nonetheless, its benefits are countered by significant security challenges that endanger the lives of its users due to the sensitivity and value of the processed data, thereby attracting malicious interests. Moreover, the utilization of wireless communication for data transmission exposes medical data to interception and tampering by cybercriminals. Additionally, anomalies may arise due to human errors, network interference, or hardware malfunctions. In this context, anomaly detection based on Machine Learning (ML) is an interesting solution, but it comes up against obstacles in terms of explicability and protection of privacy. To address these challenges, a new framework for Intrusion Detection Systems (IDS) is introduced, leveraging Artificial Neural Networks (ANN) for intrusion detection while utilizing Federated Learning (FL) for privacy preservation. Additionally, eXplainable Artificial Intelligence (XAI) methods are incorporated to enhance model explanation and interpretation. The efficacy of the proposed framework is evaluated and compared with centralized approaches using multiple datasets containing network and medical data, simulating various attack types impacting the confidentiality, integrity, and availability of medical and physiological data. The results obtained offer compelling evidence that the FL method performs comparably to the centralized method, demonstrating high performance. Additionally, it affords the dual advantage of safeguarding privacy and providing model explanation.

Background: The use of machine learning (ML) in mental health (MH) research is increasing, especially as new, more complex data types become available to analyze. By systematically examining the published literature, this review aims to uncover potential gaps in the current use of ML to study MH in vulnerable populations of immigrants, refugees, migrants, and racial and ethnic minorities. Methods: In this systematic review, we queried Google Scholar for ML-related terms, MH-related terms, and a population of a focus search term strung together with Boolean operators. Backward reference searching was also conducted. Included peer-reviewed studies reported using a method or application of ML in an MH context and focused on the populations of interest. We did not have date cutoffs. Publications were excluded if they were narrative or did not exclusively focus on a minority population from the respective country. Data including study context, the focus of mental healthcare, sample, data type, type of ML algorithm used, and algorithm performance was extracted from each. Results: Our search strategies resulted in 67,410 listed articles from Google Scholar. Ultimately, 12 were included. All the articles were published within the last 6 years, and half of them studied populations within the US. Most reviewed studies used supervised learning to explain or predict MH outcomes. Some publications used up to 16 models to determine the best predictive power. Almost half of the included publications did not discuss their cross-validation method. Conclusions: The included studies provide proof-of-concept for the potential use of ML algorithms to address MH concerns in these special populations, few as they may be. Our systematic review finds that the clinical application of these models for classifying and predicting MH disorders is still under development.

The Internet of Medical Things (IoMT) has revolutionized the healthcare industry by enabling physiological data collection using sensors, which are transmitted to remote servers for continuous analysis by physicians and healthcare professionals. This technology offers numerous benefits, including early disease detection and automatic medication for patients with chronic illnesses. However, IoMT technology also presents significant security risks, such as violating patient privacy or exposing sensitive data to interception attacks due to wireless communication, which could be fatal for the patient. Additionally, traditional security measures, such as cryptography, are challenging to implement in medical equipment due to the heterogeneous communication and their limited computation, storage, and energy capacity. These protection methods are also ineffective against new and zero-day attacks. It is essential to adopt robust security measures to ensure data integrity, confidentiality, and availability during data collection, transmission, storage, and processing. In this context, using Intrusion Detection Systems (IDS) based on Machine Learning (ML) can bring a complementary security solution adapted to the unique characteristics of IoMT systems. Therefore, this paper investigates how IDS based on ML can address security and privacy issues in IoMT systems. First, the generic three-layer architecture of IoMT is provided, and the security requirements of IoMT systems are outlined. Then, the various threats that can affect IoMT security are identified, and the advantages, disadvantages, methods, and datasets used in each solution based on ML at the three layers that make up IoMT are presented. Finally, the paper discusses the challenges and limitations of applying IDS based on ML at each layer of IoMT, which can serve as a future research direction.

Extreme multi-label text classification utilizes the label hierarchy to partition extreme labels into multiple label groups, turning the task into simple multi-group multi-label classification tasks. Current research encodes labels as a vector with fixed length which needs establish multiple classifiers for different label groups. The problem is how to build only one classifier without sacrificing the label relationship in the hierarchy. This paper adopts the multi-answer questioning task for extreme multi-label classification. This paper also proposes an auxiliary classification evaluation metric. This study adopts the proposed method and the evaluation metric to the legal domain. The utilization of legal Berts and the study on task distribution are discussed. The experiment results show that the proposed hierarchy and multi-answer questioning task can do extreme multi-label classification for EURLEX dataset. And in minor/fine-tuning the multi-label classification task, the domain adapted BERT models could not show apparent advantages in this experiment. The method is also theoretically applicable to zero-shot learning.

Unmanned Aerial Vehicles (UAVs) have recently rapidly grown to facilitate a wide range of innovative applications that can fundamentally change the way cyber-physical systems (CPSs) are designed. CPSs are a modern generation of systems with synergic cooperation between computational and physical potentials that can interact with humans through several new mechanisms. The main advantages of using UAVs in CPS application is their exceptional features, including their mobility, dynamism, effortless deployment, adaptive altitude, agility, adjustability, and effective appraisal of real-world functions anytime and anywhere. Furthermore, from the technology perspective, UAVs are predicted to be a vital element of the development of advanced CPSs. Therefore, in this survey, we aim to pinpoint the most fundamental and important design challenges of multi-UAV systems for CPS applications. We highlight key and versatile aspects that span the coverage and tracking of targets and infrastructure objects, energy-efficient navigation, and image analysis using machine learning for fine-grained CPS applications. Key prototypes and testbeds are also investigated to show how these practical technologies can facilitate CPS applications. We present and propose state-of-the-art algorithms to address design challenges with both quantitative and qualitative methods and map these challenges with important CPS applications to draw insightful conclusions on the challenges of each application. Finally, we summarize potential new directions and ideas that could shape future research in these areas.