Prior to the deep learning era, shape was commonly used to describe the objects. Nowadays, state-of-the-art (SOTA) algorithms in medical imaging are predominantly diverging from computer vision, where voxel grids, meshes, point clouds, and implicit surface models are used. This is seen from numerous shape-related publications in premier vision conferences as well as the growing popularity of ShapeNet (about 51,300 models) and Princeton ModelNet (127,915 models). For the medical domain, we present a large collection of anatomical shapes (e.g., bones, organs, vessels) and 3D models of surgical instrument, called MedShapeNet, created to facilitate the translation of data-driven vision algorithms to medical applications and to adapt SOTA vision algorithms to medical problems. As a unique feature, we directly model the majority of shapes on the imaging data of real patients. As of today, MedShapeNet includes 23 dataset with more than 100,000 shapes that are paired with annotations (ground truth). Our data is freely accessible via a web interface and a Python application programming interface (API) and can be used for discriminative, reconstructive, and variational benchmarks as well as various applications in virtual, augmented, or mixed reality, and 3D printing. Exemplary, we present use cases in the fields of classification of brain tumors, facial and skull reconstructions, multi-class anatomy completion, education, and 3D printing. In future, we will extend the data and improve the interfaces. The project pages are: https://medshapenet.ikim.nrw/ and https://github.com/Jianningli/medshapenet-feedback

In many critical applications, sensitive data is inherently distributed. Federated learning trains a model collaboratively by aggregating the parameters of locally trained models. This avoids exposing sensitive local data. It is possible, though, to infer upon the sensitive data from the shared model parameters. At the same time, many types of machine learning models do not lend themselves to parameter aggregation, such as decision trees, or rule ensembles. It has been observed that in many applications, in particular healthcare, large unlabeled datasets are publicly available. They can be used to exchange information between clients by distributed distillation, i.e., co-regularizing local training via the discrepancy between the soft predictions of each local client on the unlabeled dataset. This, however, still discloses private information and restricts the types of models to those trainable via gradient-based methods. We propose to go one step further and use a form of federated co-training, where local hard labels on the public unlabeled datasets are shared and aggregated into a consensus label. This consensus label can be used for local training by any supervised machine learning model. We show that this federated co-training approach achieves a model quality comparable to both federated learning and distributed distillation on a set of benchmark datasets and real-world medical datasets. It improves privacy over both approaches, protecting against common membership inference attacks to the highest degree. Furthermore, we show that federated co-training can collaboratively train interpretable models, such as decision trees and rule ensembles, achieving a model quality comparable to centralized training.

Flatness of the loss curve around a model at hand has been shown to empirically correlate with its generalization ability. Optimizing for flatness has been proposed as early as 1994 by Hochreiter and Schmidthuber, and was followed by more recent successful sharpness-aware optimization techniques. Their widespread adoption in practice, though, is dubious because of the lack of theoretically grounded connection between flatness and generalization, in particular in light of the reparameterization curse - certain reparameterizations of a neural network change most flatness measures but do not change generalization. Recent theoretical work suggests that a particular relative flatness measure can be connected to generalization and solves the reparameterization curse. In this paper, we derive a regularizer based on this relative flatness that is easy to compute, fast, efficient, and works with arbitrary loss functions. It requires computing the Hessian only of a single layer of the network, which makes it applicable to large neural networks, and with it avoids an expensive mapping of the loss surface in the vicinity of the model. In an extensive empirical evaluation we show that this relative flatness aware minimization (FAM) improves generalization in a multitude of applications and models, both in finetuning and standard training. We make the code available at github.