Dementia is a general term for a group of syndromes that affect cognitive functions such as memory, thinking, reasoning, and the ability to perform daily tasks. The number of dementia patients is increasing as the population ages, and it is estimated that over 10 million people develop dementia each year. Dementia progresses gradually, and the sooner a patient receives help and support, the better their chances of maintaining their functional abilities. For this reason, early diagnosis of dementia is important. In recent years, machine learning models based on naturally spoken language have been developed for the early diagnosis of dementia. These methods have proven to be user-friendly, cost-effective, scalable, and capable of providing extremely fast diagnoses. This study utilizes the well-known ADReSS challenge dataset for classifying healthy controls and Alzheimer's patients. The dataset contains speech recordings from a picture description task featuring a kitchen scene, collected from both healthy controls and dementia patients. Unlike most studies, this research does not segment the audio recordings into active speech segments; instead, acoustic features are extracted from entire recordings. The study employs Ridge linear regression, Extreme Minimal Learning Machine, and Linear Support Vector Machine machine learning models to compute feature importance scores based on model outputs. The Ridge model performed best in Leave-One-Subject-Out cross-validation, achieving a classification accuracy of 87.8%. The EMLM model, proved to be effective in both cross-validation and the classification of a separate test dataset, with accuracies of 85.3% and 79.2%, respectively. The study's results rank among the top compared to other studies using the same dataset and acoustic feature extraction for dementia diagnosis.

Memory disorders are a central factor in the decline of functioning and daily activities in elderly individuals. The confirmation of the illness, initiation of medication to slow its progression, and the commencement of occupational therapy aimed at maintaining and rehabilitating cognitive abilities require a medical diagnosis. The early identification of symptoms of memory disorders, especially the decline in cognitive abilities, plays a significant role in ensuring the well-being of populations. Features related to speech production are known to connect with the speaker's cognitive ability and changes. The lack of standardized speech tests in clinical settings has led to a growing emphasis on developing automatic machine learning techniques for analyzing naturally spoken language. Non-lexical but acoustic properties of spoken language have proven useful when fast, cost-effective, and scalable solutions are needed for the rapid diagnosis of a disease. The work presents an approach related to feature selection, allowing for the automatic selection of the essential features required for diagnosis from the Geneva minimalistic acoustic parameter set and relative speech pauses, intended for automatic paralinguistic and clinical speech analysis. These features are refined into word histogram features, in which machine learning classifiers are trained to classify control subjects and dementia patients from the Dementia Bank's Pitt audio database. The results show that achieving a 75% average classification accuracy with only twenty-five features with the separate ADReSS 2020 competition test data and the Leave-One-Subject-Out cross-validation of the entire competition data is possible. The results rank at the top compared to international research, where the same dataset and only acoustic features have been used to diagnose patients.

Tumor-stroma ratio (TSR) is a prognostic factor for many types of solid tumors. In this study, we propose a method for automated estimation of TSR from histopathological images of colorectal cancer. The method is based on convolutional neural networks which were trained to classify colorectal cancer tissue in hematoxylin-eosin stained samples into three classes: stroma, tumor and other. The models were trained using a data set that consists of 1343 whole slide images. Three different training setups were applied with a transfer learning approach using domain-specific data i.e. an external colorectal cancer histopathological data set. The three most accurate models were chosen as a classifier, TSR values were predicted and the results were compared to a visual TSR estimation made by a pathologist. The results suggest that classification accuracy does not improve when domain-specific data are used in the pre-training of the convolutional neural network models in the task at hand. Classification accuracy for stroma, tumor and other reached 96.1$\%$ on an independent test set. Among the three classes the best model gained the highest accuracy (99.3$\%$) for class tumor. When TSR was predicted with the best model, the correlation between the predicted values and values estimated by an experienced pathologist was 0.57. Further research is needed to study associations between computationally predicted TSR values and other clinicopathological factors of colorectal cancer and the overall survival of the patients.