On the Separation of Signals from Neighboring Cells in Tetrode Recordings

We discuss a solution to the problem of separating waveforms produced bymultiple cells in an extracellular neural recording. We take an explicitly probabilistic approach, using latent-variable models ofvarying sophistication to describe the distribution of waveforms producedby a single cell. The models range from a single Gaussian distribution of waveforms for each cell to a mixture of hidden Markov models. We stress the overall statistical structure of the approach, allowing the details of the generative model chosen to depend on the specific neural preparation.