Cholinergic Modulation May Enhance Cortical Associative Memory Function

James M. Bower Computation and Neural Systems Caltech 216-76 Pasadena, CA 91125 Combining neuropharmacological experiments with computational modeling, wehave shown that cholinergic modulation may enhance associative memory function in piriform (olfactory) cortex. We have shown that the acetylcholine analogue carbachol selectively suppresses synaptic transmission betweencells within piriform cortex, while leaving input connections unaffected. When tested in a computational model of piriform cortex, this selective suppression, applied during learning, enhances associative memory performance.