Simulations Suggest Information Processing Roles for the Diverse Currents in Hippocampal Neurons

Lyle J. Borg-Graham Harvard-MIT Division of Health Sciences and Technology and Center for Biological Information Processing, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 ABSTRACT A computer model of the hippocampal pyramidal cell (HPC) is described which integrates data from a variety of sources in order to develop a consistent descriptionfor this cell type. The model presently includes descriptions of eleven nonlinear somatic currents of the HPC, and the electrotonic structure of the neuron is modelled with a soma/short-cable approximation. Model simulations qualitatively or quantitatively reproduce a wide range of somatic electrical behavior i HPCs, and demonstrate possible roles for the various currents in information processing. There are several substrates for neuronal computation, including connectivity, synapses,morphometries of dendritic trees, linear parameters of cell membrane, as well as nonlinear, time-varying membrane conductances, also referred to as currents or channels. In the classical description of neuronal function, the contribution of membrane channels is constrained to that of generating the action potential, setting firing threshold, and establishing the relationship between (steady-state) stimulus intensity and firing frequency.