Daily Digest November 28, 2019 – BioDecoded

The single-molecule multiplex chromatin interaction data are generated by emerging 3D genome mapping technologies such as GAM, SPRITE, and ChIA-Drop. These datasets provide insights into high-dimensional chromatin organization, yet introduce new computational challenges. MIA-Sig is an algorithmic solution based on signal processing and information theory. The authors demonstrate its ability to de-noise the multiplex data, assess the statistical significance of chromatin complexes, and identify topological domains and frequent inter-domain contacts. Identifying personalized driver genes that lead to particular cancer initiation and progression of individual patient is one of the biggest challenges in precision medicine.