Organising for AI-by-design

What are the most successful AI use cases you know in your business, product or field? And why do you define them as successful? They've likely made a significant impact on a business metric by taking a process or customer proposition and improving them. Take radically optimised search, much cheaper logistics or highly relevant question answering, for example. While these applications and their impact are impressive and important, they often do not fundamentally change or future-proof a business, product or company.