Harnessing artificial intelligence to explore exceptional longevity

The authors thank their colleague, Leonid Tsap, for his assistance with this post. Less than 1% of Americans live to age 100. It is believed that these centenarians, and similarly long-lived individuals, may have protective molecular factors that help reduce risk or delay the onset of age-related disabilities and diseases. NIA has a longstanding interest in studying exceptional longevity because it could lead to the development of novel drugs and therapies based on these protective factors. NIA-supported studies of exceptional longevity and related research have begun to generate "multi-omics" data sets that map the complex, multilayered interplay of genetics, metabolism, proteins, and other variables.