A novel 10 gene ferroptosis related prognostic signature in acute myeloid leukemia

Acute myeloid leukemia (AML) is one of the most common hematopoietic malignancies and exhibits a high rate of relapse and unfavorable outcomes. Ferroptosis, a relatively recently described type of cell death, has been reported to be involved in cancer development. However, the prognostic value of ferroptosis related genes (FRGs) in AML remains unclear. In this study, we found 54 differentially expressed ferroptosis related genes (DEFRGs) between AML and normal marrow tissues. Using the least absolute shrinkage and selection operator (LASSO) Cox regression analysis, we selected 10 DEFRGs that were associated with OS to build a prognostic signature.