The Download: whole-body rejuvenation drugs and five things to know about AI

Plus: OpenAI has confidentially filed for a US IPO. The outspoken longevity scientist David Sinclair has predicted that, one day, you'll go to the doctor and get a prescription that will make you 10 years younger. MIT Technology Review has learned of his latest step toward this: human tests of a "reprogramming" drug. Sinclair, a biologist at Harvard Medical School, plans to launch the tests in a $101 million competition organized by the XPrize Foundation. The winners will "restore" a person to an earlier apparent age, as measured by improvements in immune, cognitive, and muscle function. The grand prize goes to any team able to show a 10-year (or greater) relative improvement after one year of treatment.