Daily Digest December 20, 2019 – BioDecoded

Digitized patient charts were supposed to revolutionize medical practice. Artificial intelligence could help unlock their potential. Identification of functional elements for a protein of interest is important for achieving a mechanistic understanding. Here, researchers report a strategy, PArsing fragmented DNA Sequences from CRISPR Tiling MUtagenesis Screening (PASTMUS), which provides a streamlined workflow and a bioinformatics pipeline to identify critical amino acids of proteins in their native biological contexts. Determining how chromosomes are positioned and folded within the nucleus is critical to understanding the role of chromatin topology in gene regulation.