thebibleofai

Through an enormous experimental effort the structures of around 100,000 unique proteins have been determined, but this represents a small fraction of the billions of known protein sequences. Structural coverage is bottlenecked by the months to years of painstaking effort required to determine a single protein structure. Accurate computational approaches are needed to address this gap and to enable large-scale structural bioinformatics. Predicting the three-dimensional structure that a protein will adopt based solely on its amino acid sequence--the structure prediction component of the'protein folding problem'--has been an important open research problem for more than 50 years. Despite recent progress existing methods fall far short of atomic accuracy, especially when no homologous structure is available.