New Algorithms Help Predict Diabetes Treatment Failure - South Florida Reporter

Metformin is the recommended first line treatment for type 2 diabetes, and is often used to prevent progression of prediabetes to diabetes. Unfortunately, it will not work for over one third of patients who take it, a condition called "therapeutic failure." Historically there has been little way of knowing whether a patient will or will not respond to this drug, however, a recent study has identified a new way to predict the treatment failure of this widely used type 2 diabetes medication, giving the healthcare provider the opportunity to consider using metformin in combination with another medication or selecting a different medication entirely. Researchers analyzed the treatment regimens and glycemic outcomes of 12,147 commercially insured and Medicare Advantage beneficiary adults and developed machine learning algorithms to predict which patients are not likely to achieve and maintain control of their blood glucose after one year of therapy. The most influential variables in the prediction were the patient's baseline hemoglobin A1C level, starting metformin at a sub-therapeutic dose, and the presence of diabetes complications at the time of treatment initiation.