The Mysterious Math of How Cells Determine Their Own Fate

In 1891, when the German biologist Hans Driesch split two-cell sea urchin embryos in half, he found that each of the separated cells then gave rise to its own complete, albeit smaller, larva. Somehow, the halves "knew" to change their entire developmental program: At that stage, the blueprint for what they would become had apparently not yet been drawn out, at least not in ink. Original story reprinted with permission from Quanta Magazine, an editorially independent publication of the Simons Foundation whose mission is to enhance public understanding of science by covering research developments and trends in mathematics and the physical and life sciences. Since then, scientists have been trying to understand what goes into making this blueprint, and how instructive it is. It's now known that some form of positional information makes genes variously switch on and off throughout the embryo, giving cells distinct identities based on their location.