Reviews: Deep Generative Markov State Models

This paper proposes a novel learning frame-work for Markov State Models of real valued vectors. This model can handle metastable processes i.e. processes that evolve locally in short time-scales but switch between a few clusters after very long periods. The proposed framework is based on a nice idea to decompose the transition from x1 to x2 to the probability that x1 belongs to a long-lived state and a distribution of x2 given the state. The first conditional probability is modeled using a decoding deep network whereas the second one can be represented either using a network that assigns weights to x2 or using a generative neural network. This is a very interesting manuscript.