Associative memory in realistic neuronal networks

Almost two decades ago, Hopfield [1] showed that networks of highly reduced model neurons can exhibit multiple attracting fixed points, thus providing a substrate for associative memory. It is still not clear, however, whether realistic neuronal networks can support multiple attractors. The main difficulty is that neuronal networks in vivo exhibit a stable background state at low firing rate, typ(cid:173) ically a few Hz. Embedding attractor is easy; doing so without destabilizing the background is not. Previous work [2, 3] focused on the sparse coding limit, in which a vanishingly small number of neurons are involved in any memory. Here we investigate the case in which the number of neurons involved in a memory scales with the number of neurons in the network.