Recent technological advancements in data acquisition tools allowed life scientists to acquire multimodal data from different biological application domains. Broadly categorized in three types (i.e., sequences, images, and signals), these data are huge in amount and complex in nature. Mining such an enormous amount of data for pattern recognition is a big challenge and requires sophisticated data-intensive machine learning techniques. Artificial neural network-based learning systems are well known for their pattern recognition capabilities and lately their deep architectures - known as deep learning (DL) - have been successfully applied to solve many complex pattern recognition problems. Highlighting the role of DL in recognizing patterns in biological data, this article provides - applications of DL to biological sequences, images, and signals data; overview of open access sources of these data; description of open source DL tools applicable on these data; and comparison of these tools from qualitative and quantitative perspectives. At the end, it outlines some open research challenges in mining biological data and puts forward a number of possible future perspectives.

Causal inference is a critical research topic across many domains, such as statistics, computer science, education, public policy and economics, for decades. Nowadays, estimating causal effect from observational data has become an appealing research direction owing to the large amount of available data and low budget requirement, compared with randomized controlled trials. Embraced with the rapidly developed machine learning area, various causal effect estimation methods for observational data have sprung up. In this survey, we provide a comprehensive review of causal inference methods under the potential outcome framework, one of the well known causal inference framework. The methods are divided into two categories depending on whether they require all three assumptions of the potential outcome framework or not. For each category, both the traditional statistical methods and the recent machine learning enhanced methods are discussed and compared. The plausible applications of these methods are also presented, including the applications in advertising, recommendation, medicine and so on. Moreover, the commonly used benchmark datasets as well as the open-source codes are also summarized, which facilitate researchers and practitioners to explore, evaluate and apply the causal inference methods.

Recent years have witnessed widespread adoption of machine learning (ML)/deep learning (DL) techniques due to their superior performance for a variety of healthcare applications ranging from the prediction of cardiac arrest from one-dimensional heart signals to computer-aided diagnosis (CADx) using multi-dimensional medical images. Notwithstanding the impressive performance of ML/DL, there are still lingering doubts regarding the robustness of ML/DL in healthcare settings (which is traditionally considered quite challenging due to the myriad security and privacy issues involved), especially in light of recent results that have shown that ML/DL are vulnerable to adversarial attacks. In this paper, we present an overview of various application areas in healthcare that leverage such techniques from security and privacy point of view and present associated challenges. In addition, we present potential methods to ensure secure and privacy-preserving ML for healthcare applications. Finally, we provide insight into the current research challenges and promising directions for future research.

How can we enable machines to make sense of the world, and become better at learning? To approach this goal, I believe viewing intelligence in terms of many integral aspects, and also a universal two-term tradeoff between task performance and complexity, provides two feasible perspectives. In this thesis, I address several key questions in some aspects of intelligence, and study the phase transitions in the two-term tradeoff, using strategies and tools from physics and information. Firstly, how can we make the learning models more flexible and efficient, so that agents can learn quickly with fewer examples? Inspired by how physicists model the world, we introduce a paradigm and an AI Physicist agent for simultaneously learning many small specialized models (theories) and the domain they are accurate, which can then be simplified, unified and stored, facilitating few-shot learning in a continual way. Secondly, for representation learning, when can we learn a good representation, and how does learning depend on the structure of the dataset? We approach this question by studying phase transitions when tuning the tradeoff hyperparameter. In the information bottleneck, we theoretically show that these phase transitions are predictable and reveal structure in the relationships between the data, the model, the learned representation and the loss landscape. Thirdly, how can agents discover causality from observations? We address part of this question by introducing an algorithm that combines prediction and minimizing information from the input, for exploratory causal discovery from observational time series. Fourthly, to make models more robust to label noise, we introduce Rank Pruning, a robust algorithm for classification with noisy labels. I believe that building on the work of my thesis we will be one step closer to enable more intelligent machines that can make sense of the world.

Its impact is drastic and real: Youtube's AIdriven recommendation system would present sports videos for days if one happens to watch a live baseball game on the platform [1]; email writing becomes much faster with machine learning (ML) based auto-completion [2]; many businesses have adopted natural language processing based chatbots as part of their customer services [3]. AI has also greatly advanced human capabilities in complex decision-making processes ranging from determining how to allocate security resources to protect airports [4] to games such as poker [5] and Go [6]. All such tangible and stunning progress suggests that an "AI summer" is happening. As some put it, "AI is the new electricity" [7]. Meanwhile, in the past decade, an emerging theme in the AI research community is the so-called "AI for social good" (AI4SG): researchers aim at developing AI methods and tools to address problems at the societal level and improve the wellbeing of the society.

Its popularity shows the Echo is staying ahead of smart speaker competitors like Google Home. On the list of top downloads, Google Home placed seventh on Google Play and ninth in the iPhone App Store. Last year, it looked like Google Home might prove a serious challenge to Amazon, but for now the device is lagging. In the U.S., Amazon Echo holds 70% of the smart speaker market, while Google Home has 25%, according to the Consumer Research Intelligence Partners. Globally, the Echo has 36.6% of the market in the third quarter, putting it significantly ahead of Google Home (12.3%) and a pack of competitors, according to analysis firm Canalys.

Large transformer-based language models (LMs) trained on huge text corpora have shown unparalleled generation capabilities. However, controlling attributes of the generated language (e.g. switching topic or sentiment) is difficult without modifying the model architecture or fine-tuning on attribute-specific data and entailing the significant cost of retraining. We propose a simple alternative: the Plug and Play Language Model (PPLM) for controllable language generation, which combines a pretrained LM with one or more simple attribute classifiers that guide text generation without any further training of the LM. In the canonical scenario we present, the attribute models are simple classifiers consisting of a user-specified bag of words or a single learned layer with 100,000 times fewer parameters than the LM. Sampling entails a forward and backward pass in which gradients from the attribute model push the LM's hidden activations and thus guide the generation. Model samples demonstrate control over a range of topics and sentiment styles, and extensive automated and human annotated evaluations show attribute alignment and fluency. PPLMs are flexible in that any combination of differentiable attribute models may be used to steer text generation, which will allow for diverse and creative applications beyond the examples given in this paper.

Research has found that many occupational accidents are foreseeable, being the result of people's unsafe behaviour from a retrospective point of view. The prediction of workers' safety behaviour will enable the prior insights into each worker's behavioural tendency and will be useful in the design of management practices prior to the occurrence of accidents and contribute to the reduction of injury rates. In recent years, researchers have found that people do have stable predispositions to engage in certain safety behavioural patterns which vary among individuals as a function of personality features. In this study, an innovative forecasting model, which employs machine learning algorithms, is developed to estimate construction workers' behavioural tendency based on the Big Five personality taxonomy. The data-driven nature of machine learning technique enabled a reliable estimate of the personality-safety behaviour relationship, which allowed this study to provide novel insight that nonlinearity may exist in the relationship between construction workers' personality traits and safety behaviour. The developed model is found to be sufficient to have satisfactory accuracy in explaining and predicting workers' safety behaviour. This finding provides the empirical evidence to support the usefulness of personality traits as effective predictors of people's safety behaviour at work. In addition, this study could have practical implications. The machine learning model developed can help identify vulnerable workers who are more prone to undertake unsafe behaviours, which is proven to have good prediction accuracy and is thereby potentially useful for decision making and safety management on construction sites.

Sexual harassment in academia is often a hidden problem because victims are usually reluctant to report their experiences. Recently, a web survey was developed to provide an opportunity to share thousands of sexual harassment experiences in academia. Using an efficient approach, this study collected and investigated more than 2,000 sexual harassment experiences to better understand these unwanted advances in higher education. This paper utilized text mining to disclose hidden topics and explore their weight across three variables: harasser gender, institution type, and victim's field of study. We mapped the topics on five themes drawn from the sexual harassment literature and found that more than 50% of the topics were assigned to the unwanted sexual attention theme. Fourteen percent of the topics were in the gender harassment theme, in which insulting, sexist, or degrading comments or behavior was directed towards women. Five percent of the topics involved sexual coercion (a benefit is offered in exchange for sexual favors), 5% involved sex discrimination, and 7% of the topics discussed retaliation against the victim for reporting the harassment, or for simply not complying with the harasser. Findings highlight the power differential between faculty and students, and the toll on students when professors abuse their power. While some topics did differ based on type of institution, there were no differences between the topics based on gender of harasser or field of study. This research can be beneficial to researchers in further investigation of this paper's dataset, and to policymakers in improving existing policies to create a safe and supportive environment in academia.

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations.