The problem of interpolating between specified images in an image but important task in model-based vision.sequence is a simple, We describe an approach based on the abstract task of "manifold learning" and present results on both synthetic and real image sequences. This problem arose in the development of a combined lipreading and speech recognition system.

The TNM staging system has been used since the early 1960's to predict breast cancer patient outcome. In an attempt to increase putative prognostic factors haveprognostic accuracy, many the TNM stage model can not accommodatebeen identified.

Several investigations have shed light on the effects of vestibular input and visual input on the head direction representation. In this paper, a model is formulated of the neural mechanisms underlying the head direction system. The model is built out of simple ingredients, depending on nothing more complicated than connectional specificity, attractor dynamics, Hebbian learning, and sigmoidal nonlinearities, but it behaves in a sophisticated way and is consistent with most of the observed properties ofreal head direction cells. In addition it makes a number of predictions that ought to be testable by reasonably straightforward experiments.

If data collection is costly, there is much to be gained by actively selecting particularly informative data points in a sequential way. In a Bayesian decision-theoretic framework we develop a query selection criterion which explicitly takes into account the intended use of the model predictions. By Markov Chain Monte Carlo methods the necessary quantities can be approximated to a desired precision. As the number of data points grows, the model complexity is modified by a Bayesian model selection strategy. The properties of two versions of the criterion ate demonstrated in numerical experiments.

Reinforcement learning-the problem of getting an agent to learn to act from sparse, delayed rewards-has been advanced by techniques based on dynamic programming (DP). These algorithms compute a value function which gives, for each state, the minimum possible long-term cost commencing in that state. For the high-dimensional and continuous state spaces characteristic of real-world control tasks, a discrete representation of the value function is intractable; some form of generalization is required. A natural way to incorporate generalization into DP is to use a function approximator, rather than a lookup table, to represent the value function. This approach, which dates back to uses of Legendre polynomials in DP [Bellman et al., 19631, has recently worked well on several dynamic control problems [Mahadevan and Connell, 1990, Lin, 1993] and succeeded spectacularly on the game of backgammon [Tesauro, 1992, Boyan, 1992]. On the other hand, many sensible implementations have been less successful [Bradtke, 1993, Schraudolph et al., 1994]. Indeed, given the well-established success 370 Justin Boyan, Andrew W. Moore

Understanding knowledge representations in neural nets has been a difficult problem. Principal components analysis (PCA) of contributions (products of sending activations and connection weights) has yielded valuable insights into knowledge representations, but much of this work has focused on the correlation matrix of contributions. The present work shows that analyzing the variance-covariance matrix of contributions yields more valid insights by taking account of weights.

In the last decade the outlines of the neural structures subserving the sense of direction have begun to emerge. Several investigations have shed light on the effects of vestibular input and visual input on the head direction representation. In this paper, a model is formulated of the neural mechanisms underlying the head direction system. The model is built out of simple ingredients, depending on nothing more complicated than connectional specificity, attractor dynamics, Hebbian learning, and sigmoidal nonlinearities, but it behaves in a sophisticated way and is consistent with most of the observed properties ofreal head direction cells. In addition it makes a number of predictions that ought to be testable by reasonably straightforward experiments.

It is well known that a combination of many different predictors can improve predictions. In the neural networks community "ensembles" of neural networks has been investigated by several authors, see for instance [1, 2, 3]. Most often the networks in the ensemble are trained individually and then their predictions are combined. This combination is usually done by majority (in classification) or by simple averaging (in regression), but one can also use a weighted combination of the networks.

In young barn owls raised with optical prisms over their eyes, these auditory maps are shifted to stay in register with the visual map, suggesting that the visual input imposes a frame of reference on the auditory maps. However, the optic tectum, the first site of convergence of visual with auditory information, is not the site of plasticity for the shift of the auditory maps; the plasticity occurs instead in the inferior colliculus, which contains an auditory map and projects into the optic tectum. We explored a model of the owl remapping in which a global reinforcement signal whose delivery is controlled by visual foveation. A hebb learning rule gated by reinforcement learned to appropriately adjust auditory maps. In addition, reinforcement learning preferentially adjusted the weights in the inferior colliculus, as in the owl brain, even though the weights were allowed to change throughout the auditory system. This observation raises the possibility that the site of learning does not have to be genetically specified, but could be determined by how the learning procedure interacts with the network architecture.

The localization and orientation to various novel or interesting events in the environment is a critical sensorimotor ability in all animals, predator or prey. In mammals, the superior colliculus (SC) plays a major role in this behavior, the deeper layers exhibiting topographically mapped responses to visual, auditory, and somatosensory stimuli. Sensory information arriving from different modalities should then be represented in the same coordinate frame. Auditory cues, in particular, are thought to be computed in head-based coordinates which must then be transformed to retinal coordinates. In this paper, an analog VLSI implementation for auditory localization in the azimuthal plane is described which extends the architecture proposed for the barn owl to a primate eye movement system where further transformation is required. This transformation is intended to model the projection in primates from auditory cortical areas to the deeper layers of the primate superior colliculus. This system is interfaced with an analog VLSI-based saccadic eye movement system also being constructed in our laboratory.