Our understanding of the input-output function of single cells has been substantially advanced by biophysically accurate multi-compartmental models. The large number of parameters needing hand tuning in these models has, however, somewhat hampered their applicability and interpretability. Here we propose a simple and well-founded method for automatic estimation of many of these key parameters: 1) the spatial distribution of channel densities on the cell's membrane; 2) the spatiotemporal pattern of synaptic input; 3) the channels' reversal potentials; 4) the intercompartmental conductances; and 5) the noise level in each compartment. We assume experimental access to: a) the spatiotemporal voltage signal in the dendrite (or some contiguous subpart thereof, e.g.

We propose a simple information-theoretic approach to soft clustering based on maximizing the mutual information I(x, y) between the unknown cluster labels y and the training patterns x with respect to parameters of specifically constrained encoding distributions. The constraints are chosen such that patterns are likely to be clustered similarly if they lie close to specific unknown vectors in the feature space. The method may be conveniently applied to learning the optimal affinity matrix, which corresponds to learning parameters of the kernelized encoder. The procedure does not require computations of eigenvalues of the Gram matrices, which makes it potentially attractive for clustering large data sets.

Probabilistic temporal planning attempts to find good policies for acting in domains with concurrent durative tasks, multiple uncertain outcomes, and limited resources. These domains are typically modelled as Markov decision problems and solved using dynamic programming methods. This paper demonstrates the application of reinforcement learning -- in the form of a policy-gradient method -- to these domains. Our emphasis is large domains that are infeasible for dynamic programming. Our approach is to construct simple policies, or agents, for each planning task. The result is a general probabilistic temporal planner, named the Factored Policy-Gradient Planner (FPG-Planner), which can handle hundreds of tasks, optimising for probability of success, duration, and resource use.

We consider the problem of modeling a helicopter's dynamics based on state-action trajectories collected from it. The contribution of this paper is twofold.

We discuss two intrinsic weaknesses of the spectral graph partitioning method, both of which have practical consequences. The first is that spectral embeddings tend to hide the best cuts from the commonly used hyperplane rounding method. Rather than cleaning up the resulting suboptimal cuts with local search, we recommend the adoption of flow-based rounding. The second weakness is that for many "power law" graphs, the spectral method produces cuts that are highly unbalanced, thus decreasing the usefulness of the method for visualization (see figure 4(b)) or as a basis for divide-and-conquer algorithms. These balance problems, which occur even though the spectral method's quotient-style objective function does encourage balance, can be fixed with a stricter balance constraint that turns the spectral mathematical program into an SDP that can be solved for million-node graphs by a method of Burer and Monteiro.

In this paper we derive an algorithm that computes the entire solution path of the support vector regression, with essentially the same computational cost as fitting one SVR model. We also propose an unbiased estimate for the degrees of freedom of the SVR model, which allows convenient selection of the regularization parameter.

Biological sensory systems are faced with the problem of encoding a high-fidelity sensory signal with a population of noisy, low-fidelity neurons. This problem can be expressed in information theoretic terms as coding and transmitting a multidimensional, analog signal over a set of noisy channels. Previously, we have shown that robust, overcomplete codes can be learned by minimizing the reconstruction error with a constraint on the channel capacity. Here, we present a theoretical analysis that characterizes the optimal linear coder and decoder for one-and twodimensional data. The analysis allows for an arbitrary number of coding units, thus including both under-and over-complete representations, and provides a number of important insights into optimal coding strategies. In particular, we show how the form of the code adapts to the number of coding units and to different data and noise conditions to achieve robustness. We also report numerical solutions for robust coding of highdimensional image data and show that these codes are substantially more robust compared against other image codes such as ICA and wavelets.

This paper presents a non-asymptotic statistical analysis of Kernel-PCA with a focus different from the one proposed in previous work on this topic. Here instead of considering the reconstruction error of KPCA we are interested in approximation error bounds for the eigenspaces themselves. We prove an upper bound depending on the spacing between eigenvalues but not on the dimensionality of the eigenspace. As a consequence this allows to infer stability results for these estimated spaces.

Although variants of value iteration have been proposed for finding Nash or correlated equilibria in general-sum Markov games, these variants have not been shown to be effective in general. In this paper, we demonstrate by construction that existing variants of value iteration cannot find stationary equilibrium policies in arbitrary general-sum Markov games. Instead, we propose an alternative interpretation of the output of value iteration based on a new (non-stationary) equilibrium concept that we call "cyclic equilibria." We prove that value iteration identifies cyclic equilibria in a class of games in which it fails to find stationary equilibria. We also demonstrate empirically that value iteration finds cyclic equilibria in nearly all examples drawn from a random distribution of Markov games.

We describe a hierarchical compositional system for detecting deformable objects in images. Objects are represented by graphical models. The algorithm uses a hierarchical tree where the root of the tree corresponds to the full object and lower-level elements of the tree correspond to simpler features.