We describe a three-dimensional geometric hand model suitable for visual trackingapplications. The kinematic constraints implied by the model's joints have a probabilistic structure which is well described by a graphical model. Inference in this model is complicated by the hand's many degrees of freedom, as well as multimodal likelihoods caused by ambiguous image measurements. We use nonparametric belief propagation (NBP)to develop a tracking algorithm which exploits the graph's structure to control complexity, while avoiding costly discretization. While kinematic constraints naturally have a local structure, self-occlusions created by the imaging process lead to complex interpendencies incolor and edge-based likelihood functions. However, we show that local structure may be recovered by introducing binary hidden variables describingthe occlusion state of each pixel. We augment the NBP algorithm to infer these occlusion variables in a distributed fashion, and then analytically marginalize over them to produce hand position estimates whichproperly account for occlusion events. We provide simulations showing that NBP may be used to refine inaccurate model initializations, aswell as track hand motion through extended image sequences.

It has been demonstrated that basic aspects of human visual motion perception arequalitatively consistent with a Bayesian estimation framework, where the prior probability distribution on velocity favors slow speeds. Here, we present a refined probabilistic model that can account for the typical trial-to-trial variabilities observed in psychophysical speed perception experiments. We also show that data from such experiments can be used to constrain both the likelihood and prior functions of the model. Specifically, we measured matching speeds and thresholds in a two-alternative forced choice speed discrimination task. Parametric fits to the data reveal that the likelihood function is well approximated by a LogNormal distribution with a characteristic contrast-dependent variance, andthat the prior distribution on velocity exhibits significantly heavier tails than a Gaussian, and approximately follows a power-law function.

The game of G0 originated in China over 4000 years ago.

We describe an approach to building brain-computer interfaces (BCI) based on graphical models for probabilistic inference and learning. We show how a dynamic Bayesian network (DBN) can be used to infer probability distributions over brain-and body-states during planning and execution of actions. The DBN is learned directly from observed data and allows measured signals such as EEG and EMG to be interpreted in terms of internal states such as intent to move, preparatory activity, and movement execution. Unlike traditional classification-based approaches to BCI, the proposed approach (1) allows continuous tracking and prediction ofinternal states over time, and (2) generates control signals based on an entire probability distribution over states rather than binary yes/no decisions. We present preliminary results of brain-and body-state estimation usingsimultaneous EEG and EMG signals recorded during a self-paced left/right hand movement task.

Alternative splicing (AS) is an important and frequent step in mammalian gene expression that allows a single gene to specify multiple products, and is crucial for the regulation of fundamental biological processes. The extent of AS regulation, and the mechanisms involved, are not well understood. We have developed a custom DNA microarray platform for surveying AS levels on a large scale. We present here a generative model for the AS Array Platform (GenASAP) and demonstrate its utility for quantifying AS levels in different mouse tissues. Learning is performed using a variational expectation maximization algorithm, and the parameters are shown to correctly capture expected AS trends. A comparison of the results obtained with a well-established but low throughput experimental method demonstrate that AS levels obtained from GenASAP are highly predictive of AS levels in mammalian tissues.

GSMs pose a critical assignment problem, working out which filter responses were generated by a common multiplicative factor.

We present a semi-parametric latent variable model based technique for density modelling, dimensionality reduction and visualization. Unlike previous methods, we estimate the latent distribution non-parametrically which enables us to model data generated by an underlying low dimensional, multimodaldistribution. In addition, we allow the components of latent variable models to be drawn from the exponential family which makes the method suitable for special data types, for example binary or count data. Simulations on real valued, binary and count data show favorable comparisonto other related schemes both in terms of separating different populations and generalization to unseen samples.

These models have been able to account for human responses in tasks ranging from 3D shape perception t0 Visuomotor control.

We present a discriminative part-based approach for the recognition of object classes from unsegmented cluttered scenes. Objects are modeled as flexible constellations of parts conditioned on local observations found by an interest operator. For each object class the probability of a given assignment of parts to local features is modeled by a Conditional Random Field(CRF). We propose an extension of the CRF framework that incorporates hidden variables and combines class conditional CRFs into a unified framework for part-based object recognition. The parameters of the CRF are estimated in a maximum likelihood framework and recognition proceedsby finding the most likely class under our model. The main advantage of the proposed CRF framework is that it allows us to relax the assumption of conditional independence of the observed data (i.e.

Log-concavity is an important property in the context of optimization, Laplace approximation, and sampling; Bayesian methods based on Gaussian processpriors have become quite popular recently for classification, regression, density estimation, and point process intensity estimation. Here we prove that the predictive densities corresponding to each of these applications are log-concave, given any observed data. We also prove that the likelihood is log-concave in the hyperparameters controlling the mean function of the Gaussian prior in the density and point process intensity estimationcases, and the mean, covariance, and observation noise parameters in the classification and regression cases; this result leads to a useful parameterization of these hyperparameters, indicating a suitably large class of priors for which the corresponding maximum a posteriori problem is log-concave. Introduction Bayesian methods based on Gaussian process priors have recently become quite popular for machine learning tasks (1). These techniques have enjoyed a good deal of theoretical examination, documenting their learning-theoretic (generalization) properties (2), and developing avariety of efficient computational schemes (e.g., (3-5), and references therein).