We present a method for localizing and separating sound sources in stereo recordings that is robust to reverberation and does not make any assumptions about the source statistics. The method consists of a probabilistic model of binaural multisource recordings and an expectation maximization algorithm for finding the maximum likelihood parameters of that model. These parameters include distributions over delays and assignments of time-frequency regions to sources. We evaluate this method against two comparable algorithms on simulations of simultaneous speech from two or three sources. Our method outperforms the others in anechoic conditions and performs as well as the better of the two in the presence of reverberation.

We present a computational Bayesian approach for Wiener diffusion models, which are prominent accounts of response time distributions in decision-making. We first develop a general closed-form analytic approximation to the response time distributions for one-dimensional diffusion processes, and derive the required Wiener diffusion as a special case. We use this result to undertake Bayesian modeling of benchmark data, using posterior sampling to draw inferences about the interesting psychological parameters. With the aid of the benchmark data, we show the Bayesian account has several advantages, including dealing naturally with the parameter variation needed to account for some key features of the data, and providing quantitative measures to guide decisions about model construction.

Many recent studies analyze how data from different modalities can be combined. Often this is modeled as a system that optimally combines several sources of information about the same variable. However, it has long been realized that this information combining depends on the interpretation of the data. Two cues that are perceived by different modalities can have different causal relationships: (1) They can both have the same cause, in this case we should fully integrate both cues into a joint estimate.

Modelling the dynamics of transcriptional processes in the cell requires the knowledge of a number of key biological quantities. While some of them are relatively easy to measure, such as mRNA decay rates and mRNA abundance levels, it is still very hard to measure the active concentration levels of the transcription factor proteins that drive the process and the sensitivity of target genes to these concentrations. In this paper we show how these quantities for a given transcription factor can be inferred from gene expression levels of a set of known target genes. We treat the protein concentration as a latent function with a Gaussian process prior, and include the sensitivities, mRNA decay rates and baseline expression levels as hyperparameters. We apply this procedure to a human leukemia dataset, focusing on the tumour repressor p53 and obtaining results in good accordance with recent biological studies.

Correlation between instances is often modelled via a kernel function using input attributes of the instances. Relational knowledge can further reveal additional pairwise correlations between variables of interest. In this paper, we develop a class of models which incorporates both reciprocal relational information and input attributes using Gaussian process techniques. This approach provides a novel nonparametric Bayesian framework with a data-dependent covariance function for supervised learning tasks. We also apply this framework to semi-supervised learning. Experimental results on several real world data sets verify the usefulness of this algorithm.

Data sets that characterize human activity over time through collections of timestamped events or counts are of increasing interest in application areas as humancomputer interaction, video surveillance, and Web data analysis. We propose a nonparametric Bayesian framework for modeling collections of such data. In particular, we use a Dirichlet process framework for learning a set of intensity functions corresponding to different categories, which form a basis set for representing individual time-periods (e.g., several days) depending on which categories the time-periods are assigned to. This allows the model to learn in a data-driven fashion what "factors" are generating the observations on a particular day, including (for example) weekday versus weekend effects or day-specific effects corresponding to unique (single-day) occurrences of unusual behavior, sharing information where appropriate to obtain improved estimates of the behavior associated with each category. Applications to real-world data sets of count data involving both vehicles and people are used to illustrate the technique.

We propose a new technique for sampling the solutions of combinatorial problems in a near-uniform manner. We focus on problems specified as a Boolean formula, i.e., on SAT instances. Sampling for SAT problems has been shown to have interesting connections with probabilistic reasoning, making practical sampling algorithms for SAT highly desirable. The best current approaches are based on Markov Chain Monte Carlo methods, which have some practical limitations.

By adopting Gaussian process priors a fully Bayesian solution to the problem of integrating possibly heterogeneous data sets within a classification setting is presented. Approximate inference schemes employing Variational & Expectation Propagation based methods are developed and rigorously assessed. We demonstrate our approach to integrating multiple data sets on a large scale protein fold prediction problem where we infer the optimal combinations of covariance functions and achieve state-of-the-art performance without resorting to any ad hoc parameter tuning and classifier combination.

We present a novel, semi-supervised approach to training discriminative random fields (DRFs) that efficiently exploits labeled and unlabeled training data to achieve improved accuracy in a variety of image processing tasks. We formulate DRF training as a form of MAP estimation that combines conditional loglikelihood on labeled data, given a data-dependent prior, with a conditional entropy regularizer defined on unlabeled data. Although the training objective is no longer concave, we develop an efficient local optimization procedure that produces classifiers that are more accurate than ones based on standard supervised DRF training. We then apply our semi-supervised approach to train DRFs to segment both synthetic and real data sets, and demonstrate significant improvements over supervised DRFs in each case.

This paper proposes a new approach to model-based clustering under prior knowledge. The proposed formulation can be interpreted from two different angles: as penalized logistic regression, where the class labels are only indirectly observed (via the probability density of each class); as finite mixture learning under a grouping prior. To estimate the parameters of the proposed model, we derive a (generalized) EM algorithm with a closed-form E-step, in contrast with other recent approaches to semi-supervised probabilistic clustering which require Gibbs sampling or suboptimal shortcuts. We show that our approach is ideally suited for image segmentation: it avoids the combinatorial nature Markov random field priors, and opens the door to more sophisticated spatial priors (e.g., wavelet-based) in a simple and computationally efficient way. Finally, we extend our formulation to work in unsupervised, semi-supervised, or discriminative modes.