We reduce a broad class of machine learning problems, usually addressed by EM or sampling, to the problem of finding the $k$ extremal rays spanning the conical hull of a data point set. These $k$ ``anchors'' lead to a global solution and a more interpretable model that can even outperform EM and sampling on generalization error. To find the $k$ anchors, we propose a novel divide-and-conquer learning scheme ``DCA'' that distributes the problem to $\mathcal O(k\log k)$ same-type sub-problems on different low-D random hyperplanes, each can be solved by any solver. For the 2D sub-problem, we present a non-iterative solver that only needs to compute an array of cosine values and its max/min entries. DCA also provides a faster subroutine for other methods to check whether a point is covered in a conical hull, which improves algorithm design in multiple dimensions and brings significant speedup to learning. We apply our method to GMM, HMM, LDA, NMF and subspace clustering, then show its competitive performance and scalability over other methods on rich datasets.

Bayesian observer models are very effective in describing human performance in perceptual tasks, so much so that they are trusted to faithfully recover hidden mental representations of priors, likelihoods, or loss functions from the data. However, the intrinsic degeneracy of the Bayesian framework, as multiple combinations of elements can yield empirically indistinguishable results, prompts the question of model identifiability. We propose a novel framework for a systematic testing of the identifiability of a significant class of Bayesian observer models, with practical applications for improving experimental design. We examine the theoretical identifiability of the inferred internal representations in two case studies. First, we show which experimental designs work better to remove the underlying degeneracy in a time interval estimation task. Second, we find that the reconstructed representations in a speed perception task under a slow-speed prior are fairly robust.

Locally weighted regression (LWR) was created as a nonparametric method that can approximate a wide range of functions, is computationally efficient, and can learn continually from very large amounts of incrementally collected data. As an interesting feature, LWR can regress on non-stationary functions, a beneficial property, for instance, in control problems. However, it does not provide a proper generative model for function values, and existing algorithms have a variety of manual tuning parameters that strongly influence bias, variance and learning speed of the results. Gaussian (process) regression, on the other hand, does provide a generative model with rather black-box automatic parameter tuning, but it has higher computational cost, especially for big data sets and if a non-stationary model is required. In this paper, we suggest a path from Gaussian (process) regression to locally weighted regression, where we retain the best of both approaches. Using a localizing function basis and approximate inference techniques, we build a Gaussian (process) regression algorithm of increasingly local nature and similar computational complexity to LWR. Empirical evaluations are performed on several synthetic and real robot datasets of increasing complexity and (big) data scale, and demonstrate that we consistently achieve on par or superior performance compared to current state-of-the-art methods while retaining a principled approach to fast incremental regression with minimal manual tuning parameters.

Multilayer Neural Networks (MNNs) are commonly trained using gradient descent-based methods, such as BackPropagation (BP). Inference in probabilistic graphical models is often done using variational Bayes methods, such as Expectation Propagation (EP). We show how an EP based approach can also be used to train deterministic MNNs. Specifically, we approximate the posterior of the weights given the data using a “mean-field” factorized distribution, in an online setting. Using online EP and the central limit theorem we find an analytical approximation to the Bayes update of this posterior, as well as the resulting Bayes estimates of the weights and outputs. Despite a different origin, the resulting algorithm, Expectation BackPropagation (EBP), is very similar to BP in form and efficiency. However, it has several additional advantages: (1) Training is parameter-free, given initial conditions (prior) and the MNN architecture. This is useful for large-scale problems, where parameter tuning is a major challenge. (2) The weights can be restricted to have discrete values. This is especially useful for implementing trained MNNs in precision limited hardware chips, thus improving their speed and energy efficiency by several orders of magnitude. We test the EBP algorithm numerically in eight binary text classification tasks. In all tasks, EBP outperforms: (1) standard BP with the optimal constant learning rate (2) previously reported state of the art. Interestingly, EBP-trained MNNs with binary weights usually perform better than MNNs with continuous (real) weights - if we average the MNN output using the inferred posterior.

We propose a novel information-theoretic approach for Bayesian optimization called Predictive Entropy Search (PES). At each iteration, PES selects the next evaluation point that maximizes the expected information gained with respect to the global maximum. PES codifies this intractable acquisition function in terms of the expected reduction in the differential entropy of the predictive distribution. This reformulation allows PES to obtain approximations that are both more accurate and efficient than other alternatives such as Entropy Search (ES). Furthermore, PES can easily perform a fully Bayesian treatment of the model hyperparameters while ES cannot. We evaluate PES in both synthetic and real-world applications, including optimization problems in machine learning, finance, biotechnology, and robotics. We show that the increased accuracy of PES leads to significant gains in optimization performance.

We consider the problem of inferring direct neural network connections from Calcium imaging time series. Inverse covariance estimation has proven to be a fast and accurate method for learning macro- and micro-scale network connectivity in the brain and in a recent Kaggle Connectomics competition inverse covariance was the main component of several top ten solutions, including our own and the winning team's algorithm. However, the accuracy of inverse covariance estimation is highly sensitive to signal preprocessing of the Calcium fluorescence time series. Furthermore, brute force optimization methods such as grid search and coordinate ascent over signal processing parameters is a time intensive process, where learning may take several days and parameters that optimize one network may not generalize to networks with different size and parameters. In this paper we show how inverse covariance estimation can be dramatically improved using a simple convolution filter prior to applying sample covariance. Furthermore, these signal processing parameters can be learned quickly using a supervised optimization algorithm. In particular, we maximize a binomial log-likelihood loss function with respect to a convolution filter of the time series and the inverse covariance regularization parameter. Our proposed algorithm is relatively fast on networks the size of those in the competition (1000 neurons), producing AUC scores with similar accuracy to the winning solution in training time under 2 hours on a cpu. Prediction on new networks of the same size is carried out in less than 15 minutes, the time it takes to read in the data and write out the solution.

The learning with privileged information setting has recently attracted a lot of attention within the machine learning community, as it allows the integration of additional knowledge into the training process of a classifier, even when this comes in the form of a data modality that is not available at test time. Here, we show that privileged information can naturally be treated as noise in the latent function of a Gaussian process classifier (GPC). That is, in contrast to the standard GPC setting, the latent function is not just a nuisance but a feature: it becomes a natural measure of confidence about the training data by modulating the slope of the GPC probit likelihood function. Extensive experiments on public datasets show that the proposed GPC method using privileged noise, called GPC+, improves over a standard GPC without privileged knowledge, and also over the current state-of-the-art SVM-based method, SVM+. Moreover, we show that advanced neural networks and deep learning methods can be compressed as privileged information.

We present an inference method for Gaussian graphical models when only pairwise distances of n objects are observed. Formally, this is a problem of estimating an n x n covariance matrix from the Mahalanobis distances dMH(xi, xj), where object xi lives in a latent feature space. We solve the problem in fully Bayesian fashion by integrating over the Matrix-Normal likelihood and a Matrix-Gamma prior; the resulting Matrix-T posterior enables network recovery even under strongly correlated features. Hereby, we generalize TiWnet, which assumes Euclidean distances with strict feature independence. In spite of the greatly increased flexibility, our model neither loses statistical power nor entails more computational cost. We argue that the extension is highly relevant as it yields significantly better results in both synthetic and real-world experiments, which is successfully demonstrated for a network of biological pathways in cancer patients.

We introduce a model where the rate of an inhomogeneous Poisson process is modified by a Chinese restaurant process. Applying a MCMC sampler to this model allows us to do posterior Bayesian inference about the number of states in Poisson-like data. Our sampler is shown to get accurate results for synthetic data and we apply it to V1 neuron spike data to find discrete firing rate states depending on the orientation of a stimulus.

We present a general framework for constructing prior distributions with structured variables. The prior is defined as the information projection of a base distribution onto distributions supported on the constraint set of interest. In cases where this projection is intractable, we propose a family of parameterized approximations indexed by subsets of the domain. We further analyze the special case of sparse structure. While the optimal prior is intractable in general, we show that approximate inference using convex subsets is tractable, and is equivalent to maximizing a submodular function subject to cardinality constraints. As a result, inference using greedy forward selection provably achieves within a factor of (1-1/e) of the optimal objective value. Our work is motivated by the predictive modeling of high-dimensional functional neuroimaging data. For this task, we employ the Gaussian base distribution induced by local partial correlations and consider the design of priors to capture the domain knowledge of sparse support. Experimental results on simulated data and high dimensional neuroimaging data show the effectiveness of our approach in terms of support recovery and predictive accuracy.