In this work, we utilize Machine Learning for early recognition of patients at high risk of acute respiratory distress syndrome (ARDS), which is critical for successful prevention strategies for this devastating syndrome. The difficulty in early ARDS recognition stems from its complex and heterogenous nature. In this study, we integrate knowledge of the heterogeneity of ARDS patients into predictive model building. Using MIMIC-III data, we first apply latent class analysis (LCA) to identify homogeneous sub-groups in the ARDS population, and then build predictive models on the partitioned data. The results indicate that significantly improved performances of prediction can be obtained for two of the three identified sub-phenotypes of ARDS. Experiments suggests that identifying sub-phenotypes is beneficial for building predictive model for ARDS.

The intelligent Processing technique is more and more attractive to researchers due to its ability to deal with key problems in Vehicular Ad hoc networks. However, several problems in applying intelligent processing technologies in VANETs remain open. The existing applications are comprehensively reviewed and discussed, and classified into different categories in this paper. Their strategies, advantages/disadvantages, and performances are elaborated. By generalizing different tactics in various applications related to different scenarios of VANETs and evaluating their performances, several promising directions for future research have been suggested.

Motivation: Radiomics refers to the high-throughput mining of quantitative features from radiographic images. It is a promising field in that it may provide a non-invasive solution for screening and classification. Standard machine learning classification and feature selection techniques, however, tend to display inferior performance in terms of (the stability of) predictive performance. This is due to the heavy multicollinearity present in radiomic data. We set out to provide an easy-to-use approach that deals with this problem. Results: We developed a four-step approach that projects the original high-dimensional feature space onto a lower-dimensional latent-feature space, while retaining most of the covariation in the data. It consists of (i) penalized maximum likelihood estimation of a redundancy filtered correlation matrix. The resulting matrix (ii) is the input for a maximum likelihood factor analysis procedure. This two-stage maximum-likelihood approach can be used to (iii) produce a compact set of stable features that (iv) can be directly used in any (regression-based) classifier or predictor. It outperforms other classification (and feature selection) techniques in both external and internal validation settings regarding survival in squamous cell cancers.

The Semantic Web Rule Language (SWRL) is a direct extension of OWL 2 DL with a subset of RuleML, and it is designed to be the rule language of the Semantic Web. This paper explores the state-of-the-art of SWRL's expressiveness extensions proposed over time. As a motivation, the effectiveness of the SWRL/OWL combination in modeling domain facts is discussed while some of the common expressive limitations of the combination are also highlighted. The paper then classifies and presents the relevant language extensions of the SWRL and their added expressive powers to the original SWRL definition. Furthermore, it provides a comparative analysis of the syntax and semantics of the proposed extensions. In conclusion, the decidability requirement and usability of each expressiveness extension are evaluated towards an efficient inclusion into the OWL ontologies.

Takagi-Sugeno-Kang (TSK) fuzzy systems are very useful machine learning models for regression problems. However, to our knowledge, there has not existed an efficient and effective training algorithm that enables them to deal with big data. Inspired by the connections between TSK fuzzy systems and neural networks, we extend three powerful neural network optimization techniques, i.e., mini-batch gradient descent, regularization, and AdaBound, to TSK fuzzy systems, and also propose a novel DropRule technique specifically for training TSK fuzzy systems. Our final algorithm, mini-batch gradient descent with regularization, DropRule and AdaBound (MBGD-RDA), can achieve fast convergence in training TSK fuzzy systems, and also superior generalization performance in testing. It can be used for training TSK fuzzy systems on datasets of any size; however, it is particularly useful for big datasets, on which currently no other efficient training algorithms exist.

In this paper, we aimed at reviewing several different approaches present today in the search for more accurate diagnostic and treatment management in mental healthcare. Our focus is on mood disorders, and in particular on the major depressive disorder (MDD). We are reviewing and discussing findings based on neuroimaging studies (MRI and fMRI) first to get the impression of the body of knowledge about the anatomical and functional differences in depression. Then, we are focusing on less expensive data-driven approach, applicable for everyday clinical practice, in particular, those based on electroencephalographic (EEG) recordings. Among those studies utilizing EEG, we are discussing a group of applications used for detecting of depression based on the resting state EEG (detection studies) and interventional studies (using stimulus in their protocols or aiming to predict the outcome of therapy). We conclude with a discussion and review of guidelines to improve the reliability of developed models that could serve improvement of diagnostic of depression in psychiatry.

We present a scalable nonparametric Bayesian method to perform network reconstruction from observed functional behavior, that at the same time infers the communities present in the network. We show that the joint reconstruction with community detection has a synergistic effect, where the edge correlations used to inform the existence of communities are inherently also used to improve the accuracy of the reconstruction, which in turn can better inform the uncovering of communities. We illustrate the use of our method with observations arising from epidemic models and the Ising model, both on synthetic and empirical networks, as well as on data containing only functional information.

The paper deals with learning probability distributions of observed data by artificial neural networks. We suggest a so-called gradient conjugate prior (GCP) update appropriate for neural networks, which is a modification of the classical Bayesian update for conjugate priors. We establish a connection between the gradient conjugate prior update and the maximization of the log-likelihood of the predictive distribution. Unlike for the Bayesian neural networks, we use deterministic weights of neural networks, but rather assume that the ground truth distribution is normal with unknown mean and variance and learn by the neural networks the parameters of a prior (normal-gamma distribution) for these unknown mean and variance. The update of the parameters is done, using the gradient that, at each step, directs towards minimizing the Kullback--Leibler divergence from the prior to the posterior distribution (both being normal-gamma). We obtain a corresponding dynamical system for the prior's parameters and analyze its properties. In particular, we study the limiting behavior of all the prior's parameters and show how it differs from the case of the classical full Bayesian update. The results are validated on synthetic and real world data sets.

Fuzzy systems have achieved great success in numerous applications. However, there are still many challenges in designing an optimal fuzzy system, e.g., how to efficiently train its parameters, how to improve its performance without adding too many parameters, how to balance the trade-off between cooperations and competitions among the rules, how to overcome the curse of dimensionality, etc. Literature has shown that by making appropriate connections between fuzzy systems and other machine learning approaches, good practices from other domains may be used to improve the fuzzy systems, and vice versa. This paper gives an overview on the functional equivalence between Takagi-Sugeno-Kang fuzzy systems and four classic machine learning approaches -- neural networks, mixture of experts, classification and regression trees, and stacking ensemble regression -- for regression problems. We also point out some promising new research directions, inspired by the functional equivalence, that could lead to solutions to the aforementioned problems. To our knowledge, this is so far the most comprehensive overview on the connections between fuzzy systems and other popular machine learning approaches, and hopefully will stimulate more hybridization between different machine learning algorithms.

In this paper we contribute a novel algorithm family, which generalizes many unsupervised techniques including unnormalized and energy models, and allows to infer different statistical modalities (e.g.~data likelihood and ratio between densities) from data samples. The proposed unsupervised technique Probabilistic Surface Optimization (PSO) views a neural network (NN) as a flexible surface which can be pushed according to loss-specific virtual stochastic forces, where a dynamical equilibrium is achieved when the point-wise forces on the surface become equal. Concretely, the surface is pushed up and down at points sampled from two different distributions, with overall up and down forces becoming functions of these two distribution densities and of force intensity magnitudes defined by loss of a particular PSO instance. The eventual force equilibrium upon convergence enforces the NN to be equal to various statistical functions depending on the used magnitude functions, such as data density. Furthermore, this dynamical-statistical equilibrium is extremely intuitive and useful, providing many implications and possible usages in probabilistic inference. Further, we provide new PSO-based approaches as demonstration of PSO exceptional usability. We also analyze PSO convergence and optimization stability, and relate them to the gradient similarity function over NN input space. Further, we propose new ways to improve the above stability. Finally, we present new instances of PSO, termed PSO-LDE, for data density estimation on logarithmic scale and also provide a new NN block-diagonal architecture for increased surface flexibility, which significantly improves estimation accuracy. Both PSO-LDE and the new architecture are combined together as a new density estimation technique. In our experiments we demonstrate this technique to produce highly accurate density estimation for 20D data.