We have developed a novel algorithm for integrating source localization and noise suppression based on a probabilistic graphical model of stimulus-evoked MEG/EEG data. Our algorithm localizes multiple dipoles while suppressing noise sources with the computational complexity equivalent to a single dipole scan, and is therefore more ef(cid:2)cient than traditional multidipole (cid:2)tting procedures. In simulation, the algorithm can accurately localize and estimate the time course of several simultaneously-active dipoles, with rotating or (cid:2)xed orientation, at noise levels typical for averaged MEG data. Furthermore, the algorithm is superior to beamforming techniques, which we show to be an approximation to our graphical model, in estimation of temporally correlated sources. Success of this algorithm for localizing auditory cortex in a tumor patient and for localizing an epileptic spike source are also demonstrated.

We present a probabilistic model applied to the fMRI video rating prediction task of the Pittsburgh Brain Activity Interpretation Competition (PBAIC) [2]. Our goal is to predict a time series of subjective, semantic ratings of a movie given functional MRI data acquired during viewing by three subjects. Our method uses conditionally trained Gaussian Markov random fields, which model both the relationships between the subjects' fMRI voxel measurements and the ratings, as well as the dependencies of the ratings across time steps and between subjects. We also employed non-traditional methods for feature selection and regularization that exploit the spatial structure of voxel activity in the brain. The model displayed good performance in predicting the scored ratings for the three subjects in test data sets, and a variant of this model was the third place entrant to the 2006 PBAIC.

Scoring structures of undirected graphical models by means of evaluating the marginal likelihood is very hard. The main reason is the presence of the parti- tion function which is intractable to evaluate, let alone integrate over. We propose to approximate the marginal likelihood by employing two levels of approximation: we assume normality of the posterior (the Laplace approximation) and approxi- mate all remaining intractable quantities using belief propagation and the linear response approximation. Em- pirically, we find that our procedure has about two orders of magnitude better accuracy than standard BIC methods for small datasets, but deteriorates when the size of the dataset grows.

The additive clustering model is widely used to infer the features of a set of stimuli from their similarities, on the assumption that similarity is a weighted linear function of common features. This paper develops a fully Bayesian formulation of the additive clustering model, using methods from nonparametric Bayesian statistics to allow the number of features to vary. We use this to explore several approaches to parameter estimation, showing that the nonparametric Bayesian approach provides a straightforward way to obtain estimates of both the number of features used in producing similarity judgments and their importance.

We present a hierarchical Bayesian model for sets of related, but different, classes of time series data. Our model performs alignment simultaneously across all classes, while detecting and characterizing class-specific differences. During inference the model produces, for each class, a distribution over a canonical representation of the class. These class-specific canonical representations are automatically aligned to one another -- preserving common sub-structures, and highlighting differences. Many practical problems over a wide range of domains require synthesizing information from several noisy examples of one or more categories in order to build a model which captures common structure and also learns the patterns of variability between categories.

Although theorists have interpreted classical conditioning as a laboratory model of Bayesian belief updating, a recent reanalysis showed that the key features that theoretical models capture about learning are artifacts of averaging over subjects. Rather than learning smoothly to asymptote (reflecting, according to Bayesian models, the gradual tradeoff from prior to posterior as data accumulate), subjects learn suddenly and their predictions fluctuate perpetually. We suggest that abrupt and unstable learning can be modeled by assuming subjects are conducting in- ference using sequential Monte Carlo sampling with a small number of samples -- one, in our simulations. Ensemble behavior resembles exact Bayesian models since, as in particle filters, it averages over many samples. Further, the model is capable of exhibiting sophisticated behaviors like retrospective revaluation at the ensemble level, even given minimally sophisticated individuals that do not track uncertainty in their beliefs over trials.

A general modeling framework is proposed that unifies nonparametric-Bayesian models, topic-models and Bayesian networks. This class of infinite state Bayes nets (ISBN) can be viewed as directed networks of'hierarchical Dirichlet processes' (HDPs) where the domain of the variables can be structured (e.g. Existing models, such as nested-DP, Pachinko allocation, mixed membership sto- chastic block models as well as a number of new models are described as ISBNs. Two experiments have been performed to illustrate these ideas.

For infants, early word learning is a chicken-and-egg problem. One way to learn a word is to observe that it co-occurs with a particular referent across different situations. Another way is to use the social context of an utterance to infer the in- tended referent of a word. Here we present a Bayesian model of cross-situational word learning, and an extension of this model that also learns which social cues are relevant to determining reference. We test our model on a small corpus of mother-infant interaction and find it performs better than competing models. Fi- nally, we show that our model accounts for experimental phenomena including mutual exclusivity, fast-mapping, and generalization from social cues.

The learning of probabilistic models with many hidden variables and non- decomposable dependencies is an important and challenging problem. In contrast to traditional approaches based on approximate inference in a single intractable model, our approach is to train a set of tractable submodels by encouraging them to agree on the hidden variables. This allows us to capture non-decomposable aspects of the data while still maintaining tractability. We propose an objective function for our approach, derive EM-style algorithms for parameter estimation, and demonstrate their effectiveness on three challenging real-world learning tasks.

A method is proposed for semiparametric estimation where parametric and non- parametric criteria are exploited in density estimation and unsupervised learning. This is accomplished by making sampling assumptions on a dataset that smoothly interpolate between the extreme of independently distributed (or id) sample data (as in nonparametric kernel density estimators) to the extreme of independent identically distributed (or iid) sample data. This article makes independent simi- larly distributed (or isd) sampling assumptions and interpolates between these two using a scalar parameter. The parameter controls a Bhattacharyya affinity penalty between pairs of distributions on samples. Surprisingly, the isd method maintains certain consistency and unimodality properties akin to maximum likelihood esti- mation.