This paper introduces Ready2Unlearn, a learning-time optimization approach designed to facilitate future unlearning processes. Unlike the majority of existing unlearning efforts that focus on designing unlearning algorithms, which are typically implemented reactively when an unlearning request is made during the model deployment phase, Ready2Unlearn shifts the focus to the training phase, adopting a "forward-looking" perspective. Building upon well-established meta-learning principles, Ready2Unlearn proactively trains machine learning models with unlearning readiness, such that they are well prepared and can handle future unlearning requests in a more efficient and principled manner. Ready2Unlearn is model-agnostic and compatible with any gradient ascent-based machine unlearning algorithms. We evaluate the method on both vision and language tasks under various unlearning settings, including class-wise unlearning and random data unlearning. Experimental results show that by incorporating such preparedness at training time, Ready2Unlearn produces an unlearning-ready model state, which offers several key advantages when future unlearning is required, including reduced unlearning time, improved retention of overall model capability, and enhanced resistance to the inadvertent recovery of forgotten data. We hope this work could inspire future efforts to explore more proactive strategies for equipping machine learning models with built-in readiness towards more reliable and principled machine unlearning.

Recent advances in artificial intelligence (AI) and quantum computing are accelerating automation in scientific and engineering processes, fundamentally reshaping research methodologies. This perspective highlights parallels between scientific automation and established Computer-Aided Engineering (CAE) practices, introducing Quantum CAE as a framework that leverages quantum algorithms for simulation, optimization, and machine learning within engineering design. Practical implementations of Quantum CAE are illustrated through case studies for combinatorial optimization problems. Further discussions include advancements toward higher automation levels, highlighting the critical role of specialized AI agents proficient in quantum algorithm design. The integration of quantum computing with AI raises significant questions about the collaborative dynamics among human scientists and engineers, AI systems, and quantum computational resources, underscoring a transformative future for automated discovery and innovation.

Portfolio optimization involves selecting asset weights to minimize a risk-reward objective, such as the portfolio variance in the classical minimum-variance framework. Sparse portfolio selection extends this by imposing a cardinality constraint: only $k$ assets from a universe of $p$ may be included. The standard approach models this problem as a mixed-integer quadratic program and relies on commercial solvers to find the optimal solution. However, the computational costs of such methods increase exponentially with $k$ and $p$, making them too slow for problems of even moderate size. We propose a fast and scalable gradient-based approach that transforms the combinatorial sparse selection problem into a constrained continuous optimization task via Boolean relaxation, while preserving equivalence with the original problem on the set of binary points. Our algorithm employs a tunable parameter that transmutes the auxiliary objective from a convex to a concave function. This allows a stable convex starting point, followed by a controlled path toward a sparse binary solution as the tuning parameter increases and the objective moves toward concavity. In practice, our method matches commercial solvers in asset selection for most instances and, in rare instances, the solution differs by a few assets whilst showing a negligible error in portfolio variance.

This case study applies a phased hyperparameter optimization process to compare multitask natural language model variants that utilize multiphase learning rate scheduling and optimizer parameter grouping. We employ short, Bayesian optimization sessions that leverage multi-fidelity, hyperparameter space pruning, progressive halving, and a degree of human guidance. We utilize the Optuna TPE sampler and Hyperband pruner, as well as the Scikit-Learn Gaussian process minimization. Initially, we use efficient low-fidelity sprints to prune the hyperparameter space. Subsequent sprints progressively increase their model fidelity and employ hyperband pruning for efficiency. A second aspect of our approach is using a meta-learner to tune threshold values to resolve classification probabilities during inference. We demonstrate our method on a collection of variants of the 2021 Joint Entity and Relation Extraction model proposed by Eberts and Ulges.

We propose a reinforcement learning (RL) framework under a broad class of risk objectives, characterized by convex scoring functions. This class covers many common risk measures, such as variance, Expected Shortfall, entropic Value-at-Risk, and mean-risk utility. To resolve the time-inconsistency issue, we consider an augmented state space and an auxiliary variable and recast the problem as a two-state optimization problem. We propose a customized Actor-Critic algorithm and establish some theoretical approximation guarantees. A key theoretical contribution is that our results do not require the Markov decision process to be continuous. Additionally, we propose an auxiliary variable sampling method inspired by the alternating minimization algorithm, which is convergent under certain conditions. We validate our approach in simulation experiments with a financial application in statistical arbitrage trading, demonstrating the effectiveness of the algorithm.

-- This paper addresses the problem of motion planning for differential drive micro-mobility platforms. This class of vehicle is designed to perform small-distance transportation of passengers and goods in structured environments. Our approach leverages mixed-integer linear programming (MILP) to compute global optimal collision-free trajectories taking into account the kinematics and dynamics of the vehicle. We propose novel constraints for intersample collision avoidance and demonstrate its effectiveness using pick-up and delivery missions and statistical analysis of Monte Carlo simulations. The results show that the novel formulation provides the best trajectories in terms of time expenditure and control effort when compared to two state-of-the-art approaches.

Independent component analysis (ICA) is a powerful tool for decomposing a multivariate signal or distribution into fully independent sources, not just uncorrelated ones. Unfortunately, most approaches to ICA are not robust against outliers. Here we propose a robust ICA method called RICA, which estimates the components by minimizing a robust measure of dependence between multivariate random variables. The dependence measure used is the distance correlation (dCor). In order to make it more robust we first apply a new transformation called the bowl transform, which is bounded, one-to-one, continuous, and maps far outliers to points close to the origin. This preserves the crucial property that a zero dCor implies independence. RICA estimates the independent sources sequentially, by looking for the component that has the smallest dCor with the remainder. RICA is strongly consistent and has the usual parametric rate of convergence. Its robustness is investigated by a simulation study, in which it generally outperforms its competitors. The method is illustrated on three applications, including the well-known cocktail party problem.

Reinforcement learning (RL) typically models the interaction between the agent and environment as a Markov decision process (MDP), where the rewards that guide the agent's behavior are always observable. However, in many real-world scenarios, rewards are not always observable, which can be modeled as a monitored Markov decision process (Mon-MDP). Prior work on Mon-MDPs have been limited to simple, tabular cases, restricting their applicability to real-world problems. This work explores Mon-MDPs using function approximation (FA) and investigates the challenges involved. We show that combining function approximation with a learned reward model enables agents to generalize from monitored states with observable rewards, to unmonitored environment states with unobservable rewards. Therefore, we demonstrate that such generalization with a reward model achieves near-optimal policies in environments formally defined as unsolvable. However, we identify a critical limitation of such function approximation, where agents incorrectly extrapolate rewards due to overgeneralization, resulting in undesirable behaviors. To mitigate overgeneralization, we propose a cautious police optimization method leveraging reward uncertainty. This work serves as a step towards bridging this gap between Mon-MDP theory and real-world applications.

Photonic chip design has seen significant advancements with the adoption of inverse design methodologies, offering flexibility and efficiency in optimizing device performance. However, the black-box nature of the optimization approaches, such as those used in inverse design in order to minimize a loss function or maximize coupling efficiency, poses challenges in understanding the outputs. This challenge is prevalent in machine learning-based optimization methods, which can suffer from the same lack of transparency. To this end, interpretability techniques address the opacity of optimization models. In this work, we apply interpretability techniques from machine learning, with the aim of gaining understanding of inverse design optimization used in designing photonic components, specifically two-mode multiplexers. We base our methodology on the widespread interpretability technique known as local interpretable model-agnostic explanations, or LIME. As a result, LIME-informed insights point us to more effective initial conditions, directly improving device performance. This demonstrates that interpretability methods can do more than explain models -- they can actively guide and enhance the inverse-designed photonic components. Our results demonstrate the ability of interpretable techniques to reveal underlying patterns in the inverse design process, leading to the development of better-performing components.

Designing biological sequences that satisfy multiple, often conflicting, functional and biophysical criteria remains a central challenge in biomolecule engineering. While discrete flow matching models have recently shown promise for efficient sampling in high-dimensional sequence spaces, existing approaches address only single objectives or require continuous embeddings that can distort discrete distributions. We present Multi-Objective-Guided Discrete Flow Matching (MOG-DFM), a general framework to steer any pretrained discrete flow matching generator toward Pareto-efficient trade-offs across multiple scalar objectives. At each sampling step, MOG-DFM computes a hybrid rank-directional score for candidate transitions and applies an adaptive hypercone filter to enforce consistent multi-objective progression. We also trained two unconditional discrete flow matching models, PepDFM for diverse peptide generation and EnhancerDFM for functional enhancer DNA generation, as base generation models for MOG-DFM. We demonstrate MOG-DFM's effectiveness in generating peptide binders optimized across five properties (hemolysis, non-fouling, solubility, half-life, and binding affinity), and in designing DNA sequences with specific enhancer classes and DNA shapes. In total, MOG-DFM proves to be a powerful tool for multi-property-guided biomolecule sequence design.