The global objective of this work is to provide practical optimization methods to companies involved in inventory routing problems, taking into account this new type of data. Also, companies are sometimes not able to deal with changing plans every period and would like to adopt regular structures for serving customers.

Motivated by problems of anomaly detection, this paper implements the Neyman-Pearson paradigm to deal with asymmetric errors in binary classification with a convex loss. Given a finite collection of classifiers, we combine them and obtain a new classifier that satisfies simultaneously the two following properties with high probability: (i) its probability of type I error is below a pre-specified level and (ii), it has probability of type II error close to the minimum possible. The proposed classifier is obtained by solving an optimization problem with an empirical objective and an empirical constraint. New techniques to handle such problems are developed and have consequences on chance constrained programming.

External information propagates in the cell mainly through signaling cascades and transcriptional activation, allowing it to react to a wide spectrum of environmental changes. High throughput experiments identify numerous molecular components of such cascades that may, however, interact through unknown partners. Some of them may be detected using data coming from the integration of a protein-protein interaction network and mRNA expression profiles. This inference problem can be mapped onto the problem of finding appropriate optimal connected subgraphs of a network defined by these datasets. The optimization procedure turns out to be computationally intractable in general. Here we present a new distributed algorithm for this task, inspired from statistical physics, and apply this scheme to alpha factor and drug perturbations data in yeast. We identify the role of the COS8 protein, a member of a gene family of previously unknown function, and validate the results by genetic experiments. The algorithm we present is specially suited for very large datasets, can run in parallel, and can be adapted to other problems in systems biology. On renowned benchmarks it outperforms other algorithms in the field.

Although researchers often comment on the rising popularity of nature-inspired meta-heuristics (NIM), there has been a paucity of data to directly support the claim that NIM are growing in prominence compared to other optimization techniques. This study presents evidence that the use of NIM is not only growing, but indeed appears to have surpassed mathematical optimization techniques (MOT) in several important metrics related to academic research activity (publication frequency) and commercial activity (patenting frequency). Motivated by these findings, this article discusses some of the possible origins of this growing popularity. I review different explanations for NIM popularity and discuss why some of these arguments remain unsatisfying. I argue that a compelling and comprehensive explanation should directly account for the manner in which most NIM success has actually been achieved, e.g. through hybridization and customization to different problem environments. By taking a problem lifecycle perspective, this paper offers a fresh look at the hypothesis that nature-inspired meta-heuristics derive much of their utility from being flexible. I discuss global trends within the business environments where optimization algorithms are applied and I speculate that highly flexible algorithm frameworks could become increasingly popular within our diverse and rapidly changing world.

Game-theoretic solution concepts prescribe how rational parties should act, but to become operational the concepts need to be accompanied by algorithms. I will review the state of solving incomplete-information games. They encompass many practical problems such as auctions, negotiations, and security applications. I will discuss them in the context of how they have transformed computer poker. In short, game-theoretic reasoning now scales to many large problems, outperforms the alternatives on those problems, and in some games beats the best humans.

Markovian processes have long been used to model stochastic environments. Reinforcement learning has emerged as a framework to solve sequential planning and decision-making problems in such environments. In recent years, attempts were made to apply methods from reinforcement learning to construct decision support systems for action selection in Markovian environments. Although conventional methods in reinforcement learning have proved to be useful in problems concerning sequential decision-making, they cannot be applied in their current form to decision support systems, such as those in medical domains, as they suggest policies that are often highly prescriptive and leave little room for the user's input. Without the ability to provide flexible guidelines, it is unlikely that these methods can gain ground with users of such systems. This paper introduces the new concept of non-deterministic policies to allow more flexibility in the user's decision-making process, while constraining decisions to remain near optimal solutions. We provide two algorithms to compute non-deterministic policies in discrete domains. We study the output and running time of these method on a set of synthetic and real-world problems. In an experiment with human subjects, we show that humans assisted by hints based on non-deterministic policies outperform both human-only and computer-only agents in a web navigation task.

We analyze the convergence behaviour of a recently proposed algorithm for regularized estimation called Dual Augmented Lagrangian (DAL). Our analysis is based on a new interpretation of DAL as a proximal minimization algorithm. We theoretically show under some conditions that DAL converges super-linearly in a non-asymptotic and global sense. Due to a special modelling of sparse estimation problems in the context of machine learning, the assumptions we make are milder and more natural than those made in conventional analysis of augmented Lagrangian algorithms. In addition, the new interpretation enables us to generalize DAL to wide varieties of sparse estimation problems. We experimentally confirm our analysis in a large scale $\ell_1$-regularized logistic regression problem and extensively compare the efficiency of DAL algorithm to previously proposed algorithms on both synthetic and benchmark datasets.

We propose a new LP relaxation for obtaining the MAP assignment of a binary MRF with pairwise potentials. Our relaxation is derived from reducing the MAP assignment problem to an instance of a recently proposed Bipartite Multi-cut problem where the LP relaxation is guaranteed to provide an O(log k) approximation where k is the number of vertices adjacent to non-submodular edges in the MRF. We then propose a combinatorial algorithm to efficiently solve the LP and also provide a lower bound by concurrently solving its dual to within an ɛ approximation. The algorithm is up to an order of magnitude faster and provides better MAP scores and bounds than the state of the art message passing algorithm of [1] that tightens the local marginal polytope with third-order marginal constraints.

We propose a new LP relaxation for obtaining the MAP assignment of a binary MRF with pairwise potentials. Our relaxation is derived from reducing the MAP assignment problem to an instance of a recently proposed Bipartite Multi-cut problem where the LP relaxation is guaranteed to provide an O(log k) approximation where k is the number of vertices adjacent to non-submodular edges in the MRF. We then propose a combinatorial algorithm to efficiently solve the LP and also provide a lower bound by concurrently solving its dual to within an ɛ approximation. The algorithm is up to an order of magnitude faster and provides better MAP scores and bounds than the state of the art message passing algorithm of [1] that tightens the local marginal polytope with third-order marginal constraints.

We study the problem of learning a sparse linear regression vector under additional conditions on the structure of its sparsity pattern. We present a family of convex penalty functions, which encode this prior knowledge by means of a set of constraints on the absolute values of the regression coefficients. This family subsumes the $\ell_1$ norm and is flexible enough to include different models of sparsity patterns, which are of practical and theoretical importance. We establish some important properties of these functions and discuss some examples where they can be computed explicitly. Moreover, we present a convergent optimization algorithm for solving regularized least squares with these penalty functions. Numerical simulations highlight the benefit of structured sparsity and the advantage offered by our approach over the Lasso and other related methods.