Abstract--Autonomous agents utilizing Large Language Models (LLMs) have demonstrated remarkable capabilities in isolated medical tasks like diagnosis and image analysis, but struggle with integrated clinical workflows that connect diagnostic reasoning and medication decisions. We identify a core limitation: existing medical AI systems process tasks in isolation without the cross-validation and knowledge integration found in clinical teams, reducing their effectiveness in real-world healthcare scenarios. T o transform the isolation paradigm into a collaborative approach, we propose MedCoAct, a confidence-aware multi-agent framework that simulates clinical collaboration by integrating specialized doctor and pharmacist agents, and present a benchmark, DrugCareQA, to evaluate medical AI capabilities in integrated diagnosis and treatment workflows. Our results demonstrate that MedCoAct achieves 67.58% diagnostic accuracy and 67.58% medication recommendation accuracy, outperforming single agent framework by 7.04% and 7.08% respectively. In healthcare, LLMs have demonstrated capabilities across diverse applications. Medical question-answering systems provide rapid access to comprehensive clinical knowledge and evidence-based recommendations [1]-[3]. LLMs assist also with medical imaging report generation, significantly reducing physician workload [4]. Moreover, LLMs help drug discovery research by accelerating molecular design and optimization processes [5].

Intraoperative pathology is pivotal to precision surgery, yet its clinical impact is constrained by diagnostic complexity and the limited availability of high-quality frozen-section data. While computational pathology has made significant strides, the lack of large-scale, prospective validation has impeded its routine adoption in surgical workflows. Here, we introduce CRISP, a clinical-grade foundation model developed on over 100,000 frozen sections from eight medical centers, specifically designed to provide Clinical-grade Robust Intraoperative Support for Pathology (CRISP). CRISP was comprehensively evaluated on more than 15,000 intraoperative slides across nearly 100 retrospective diagnostic tasks, including benign-malignant discrimination, key intraoperative decision-making, and pan-cancer detection, etc. The model demonstrated robust generalization across diverse institutions, tumor types, and anatomical sites-including previously unseen sites and rare cancers. In a prospective cohort of over 2,000 patients, CRISP sustained high diagnostic accuracy under real-world conditions, directly informing surgical decisions in 92.6% of cases. Human-AI collaboration further reduced diagnostic workload by 35%, avoided 105 ancillary tests and enhanced detection of micrometastases with 87.5% accuracy. Together, these findings position CRISP as a clinical-grade paradigm for AI-driven intraoperative pathology, bridging computational advances with surgical precision and accelerating the translation of artificial intelligence into routine clinical practice.

Massive multiple-input multiple-output (MMIMO) is essential to modern wireless communication systems, like 5G and 6G, but it is vulnerable to active eavesdropping attacks. One type of such attack is the pilot contamination attack (PCA), where a malicious user copies pilot signals from an authentic user during uplink, intentionally interfering with the base station's (BS) channel estimation accuracy. In this work, we propose to use a Decision Tree (DT) algorithm for PCA detection at the BS in a multi-user system. We present a methodology to generate training data for the DT classifier and select the best DT according to their depth. Then, we simulate different scenarios that could be encountered in practice and compare the DT to a classical technique based on likelihood ratio testing (LRT) submitted to the same scenarios. The results revealed that a DT with only one level of depth is sufficient to outperform the LRT. The DT shows a good performance regarding the probability of detection in noisy scenarios and when the malicious user transmits with low power, in which case the LRT fails to detect the PCA. We also show that the reason for the good performance of the DT is its ability to compute a threshold that separates PCA data from non-PCA data better than the LRT's threshold. Moreover, the DT does not necessitate prior knowledge of noise power or assumptions regarding the signal power of malicious users, prerequisites typically essential for LRT and other hypothesis testing methodologies.

Medical diagnostics is a high-stakes and complex domain that is critical to patient care. However, current evaluations of large language models (LLMs) are fundamentally misaligned with real-world clinical practice. Most of them rely on static benchmarks derived from public medical exam items, which tend to overestimate model performance and ignore the difference between textbook cases and the ambiguous, varying conditions in the real world. Recent efforts toward dynamic evaluation offer a promising alternative, but their improvements are limited to superficial perturbations and a narrow focus on accuracy. To address these gaps, we propose DyReMe, a dynamic benchmark for medical diagnostics that better reflects real clinical practice. Unlike static exam-style questions, DyReMe generates fresh, consultation-like cases that introduce distractors such as differential diagnoses and common misdiagnosis factors. It also varies expression styles to mimic diverse real-world query habits. Beyond accuracy, DyReMe evaluates LLMs on three additional clinically relevant dimensions: veracity, helpfulness, and consistency. Our experiments demonstrate that this dynamic approach yields more challenging and realistic assessments, revealing significant misalignments between the performance of state-of-the-art LLMs and real clinical practice. These findings highlight the urgent need for evaluation frameworks that better reflect the demands of trustworthy medical diagnostics.

Causal discovery for dynamical systems poses a major challenge in fields where active interventions are infeasible. Most methods used to investigate these systems and their associated benchmarks are tailored to deterministic, low-dimensional and weakly nonlinear time-series data. To address these limitations, we present CausalDynamics, a large-scale benchmark and extensible data generation framework to advance the structural discovery of dynamical causal models. Our benchmark consists of true causal graphs derived from thousands of both linearly and nonlinearly coupled ordinary and stochastic differential equations as well as two idealized climate models. We perform a comprehensive evaluation of state-of-the-art causal discovery algorithms for graph reconstruction on systems with noisy, confounded, and lagged dynamics. CausalDynamics consists of a plug-and-play, build-your-own coupling workflow that enables the construction of a hierarchy of physical systems. We anticipate that our framework will facilitate the development of robust causal discovery algorithms that are broadly applicable across domains while addressing their unique challenges. We provide a user-friendly implementation and documentation on https://kausable.github.io/CausalDynamics.

Shoulder disorders, such as frozen shoulder (a.k.a., adhesive capsulitis), are common conditions affecting the health of people worldwide, and have a high incidence rate among the elderly and workers engaged in repetitive shoulder tasks. In regions with scarce medical resources, achieving early and accurate diagnosis poses significant challenges, and there is an urgent need for low-cost and easily scalable auxiliary diagnostic solutions. This research introduces videos captured by consumer-grade devices as the basis for diagnosis, reducing the cost for users. We focus on the innovative application of Multimodal Large Language Models (MLLMs) in the preliminary diagnosis of shoulder disorders and propose a Hybrid Motion Video Diagnosis framework (HMVDx). This framework divides the two tasks of action understanding and disease diagnosis, which are respectively completed by two MLLMs. In addition to traditional evaluation indicators, this work proposes a novel metric called Usability Index by the logical process of medical decision-making (action recognition, movement diagnosis, and final diagnosis). This index evaluates the effectiveness of MLLMs in the medical field from the perspective of the entire medical diagnostic pathway, revealing the potential value of low-cost MLLMs in medical applications for medical practitioners. In experimental comparisons, the accuracy of HMVDx in diagnosing shoulder joint injuries has increased by 79.6\% compared with direct video diagnosis, a significant technical contribution to future research on the application of MLLMs for video understanding in the medical field.

As machine learning (ML) algorithms are increasingly used in medical image analysis, concerns have emerged about their potential biases against certain social groups. Although many approaches have been proposed to ensure the fairness of ML models, most existing works focus only on medical image diagnosis tasks, such as image classification and segmentation, and overlooked prognosis scenarios, which involve predicting the likely outcome or progression of a medical condition over time. To address this gap, we introduce FairTTE, the first comprehensive framework for assessing fairness in time-to-event (TTE) prediction in medical imaging. FairTTE encompasses a diverse range of imaging modalities and TTE outcomes, integrating cutting-edge TTE prediction and fairness algorithms to enable systematic and fine-grained analysis of fairness in medical image prognosis. Leveraging causal analysis techniques, FairTTE uncovers and quantifies distinct sources of bias embedded within medical imaging datasets. Our large-scale evaluation reveals that bias is pervasive across different imaging modalities and that current fairness methods offer limited mitigation. We further demonstrate a strong association between underlying bias sources and model disparities, emphasizing the need for holistic approaches that target all forms of bias. Notably, we find that fairness becomes increasingly difficult to maintain under distribution shifts, underscoring the limitations of existing solutions and the pressing need for more robust, equitable prognostic models.

Table 1 provides a detailed breakdown of the disease categories included in DiReCT. As some premise may not included in the referred guidelines.

Here we cover the full specification of the experiments. Some details were omitted from the main text. If there were separate training and test sets, they were combined before creating the random 10-fold split. All attributes are normalized to mean 0 and standard deviation 1. Additional details for each model type follow.

Industrial fault diagnosis faces the dual challenges of data scarcity and the difficulty of deploying large AI models in resource-constrained environments. This paper introduces Syn-Diag, a novel cloud-edge synergistic framework that leverages Large Language Models to overcome these limitations in few-shot fault diagnosis. Syn-Diag is built on a three-tiered mechanism: 1) Visual-Semantic Synergy, which aligns signal features with the LLM's semantic space through cross-modal pre-training; 2) Content-Aware Reasoning, which dynamically constructs contextual prompts to enhance diagnostic accuracy with limited samples; and 3) Cloud-Edge Synergy, which uses knowledge distillation to create a lightweight, efficient edge model capable of online updates via a shared decision space. Extensive experiments on six datasets covering different CWRU and SEU working conditions show that Syn-Diag significantly outperforms existing methods, especially in 1-shot and cross-condition scenarios. The edge model achieves performance comparable to the cloud version while reducing model size by 83% and latency by 50%, offering a practical, robust, and deployable paradigm for modern intelligent diagnostics.