Artificial intelligence has advanced significantly through deep learning, reinforcement learning, and large language and vision models. However, these systems often remain task specific, struggle to adapt to changing conditions, and cannot generalize in ways similar to human cognition. Additionally, they mainly focus on mimicking brain structures, which often leads to black-box models with limited transparency and adaptability. Inspired by the structure and function of biological cognition, this paper introduces the concept of "Neurocognitive-Inspired Intelligence (NII)," a hybrid approach that combines neuroscience, cognitive science, computer vision, and AI to develop more general, adaptive, and robust intelligent systems capable of rapid learning, learning from less data, and leveraging prior experience. These systems aim to emulate the human brain's ability to flexibly learn, reason, remember, perceive, and act in real-world settings with minimal supervision. We review the limitations of current AI methods, define core principles of neurocognitive-inspired intelligence, and propose a modular, biologically inspired architecture that emphasizes integration, embodiment, and adaptability. We also discuss potential implementation strategies and outline various real-world applications, from robotics to education and healthcare. Importantly, this paper offers a hybrid roadmap for future research, laying the groundwork for building AI systems that more closely resemble human cognition.

A2AS enforces certified behavior, activates model self-defense, and ensures context wi ndow i ntegrity. It defi nes security boundaries, authentic ates prompts, applies security rules and custom policies, and cont rols agentic behavior, enabli ng a defense-i n-depth st rategy. The A2AS framework avoids latency overhe ad, external dependencies, architectural changes, model ret rai ni ng, and operational complexity. The BASIC security model is i nt roduced as the A2AS foundation: (B) Behavior certific ates enable behavior enforcement, (A) Authentic ated prompts enable context wi ndow i ntegrity, (S) S ecurity boundaries enable unt rusted i nput isol ation, (I) I n-context defenses enable secure model re asoni ng, (C) Codified policies enable applic ation-specific rules. The advancements i n Artificial I ntelligence (AI) and its i ntegration across sensitive fields, such as he althc are, fi nance, and critic al i nfrast ructure, have i ncre ased the attack surface of such AI systems. They expose applic ations and data to risks of exfilt ration, i nfection, and mani pulation, potentially compromisi ng confidentiality, i ntegrity, and availability. Movi ng beyond theoretic al risks, a growi ng number of re al-world AI security i ncidents are bei ng reported [1] . The developments i n Large Language Models (LLMs) have i nt roduced a p aradigm shift i n AI engi neeri ng, where buildi ng AI systems is largely centered around i ntegrati ng LLM models. These models have thei r i nherent vulnerabilities that exp and the attack surface and i nt roduce additional security risks.

As the global reach of online higher education continues to grow, universities are increasingly accommodating students from diverse cultural backgrounds (Tereshko et al., 2024). This can present a number of challenges including linguistic barriers (Ullah et al., 2021), cultural differences in learning style (Omidvar & Tan, 2012), cultural sensitivity in course design (Nguyen, 2022) and perceived isolation when students feel their perspectives or experiences are not reflected or valued in the learning environment (Hansen-Brown et al., 2022). Ensuring active engagement and reasonable learning outcomes in such a environments requires distance educational systems that are not only adaptive but also culturally resonant (Dalle et al., 2024). Both embodied and virtual AI-Agents have great potential in this regard as they can facilitate personalized learning and adapt their interactions and content delivery to align with students' cultural context. In addition, Generative AI (GAI), such as, Large Language Models (LLMs) can amplify the potential for these culturally aware AI agents to address educational challenges due to their advanced capacity for understanding and generating contextually relevant content (Wang et al., 2024). This chapter reviews existing research and suggests the usage of culturally aware AI-Agents, powered by GAI, to foster engagement and improve learning outcomes in culturally diverse online higher education environments.

Computational drug repurposing for rare diseases is especially challenging when no prior associations exist between drugs and target diseases. Therefore, knowledge graph completion and message-passing GNNs have little reliable signal to learn and propagate, resulting in poor performance. We present RareAgent, a self-evolving multi-agent system that reframes this task from passive pattern recognition to active evidence-seeking reasoning. RareAgent organizes task-specific adversarial debates in which agents dynamically construct evidence graphs from diverse perspectives to support, refute, or entail hypotheses. The reasoning strategies are analyzed post hoc in a self-evolutionary loop, producing textual feedback that refines agent policies, while successful reasoning paths are distilled into transferable heuristics to accelerate future investigations. Comprehensive evaluations reveal that RareAgent improves the indication AUPRC by 18.1% over reasoning baselines and provides a transparent reasoning chain consistent with clinical evidence.

We introduce Paper2Agent, an automated framework that converts research papers into AI agents. Paper2Agent transforms research output from passive artifacts into active systems that can accelerate downstream use, adoption, and discovery. Conventional research papers require readers to invest substantial effort to understand and adapt a paper's code, data, and methods to their own work, creating barriers to dissemination and reuse. Paper2Agent addresses this challenge by automatically converting a paper into an AI agent that acts as a knowledgeable research assistant. It systematically analyzes the paper and the associated codebase using multiple agents to construct a Model Context Protocol (MCP) server, then iteratively generates and runs tests to refine and robustify the resulting MCP. These paper MCPs can then be flexibly connected to a chat agent (e.g. Claude Code) to carry out complex scientific queries through natural language while invoking tools and workflows from the original paper. We demonstrate Paper2Agent's effectiveness in creating reliable and capable paper agents through in-depth case studies. Paper2Agent created an agent that leverages AlphaGenome to interpret genomic variants and agents based on ScanPy and TISSUE to carry out single-cell and spatial transcriptomics analyses. We validate that these paper agents can reproduce the original paper's results and can correctly carry out novel user queries. Paper2Agent automatically created AI co-scientist that identified new splicing variant associated with ADHD risk. By turning static papers into dynamic, interactive AI agents, Paper2Agent introduces a new paradigm for knowledge dissemination and a foundation for the collaborative ecosystem of AI co-scientists.

Agent-based modeling (ABM) is a principal approach for studying complex systems. By decomposing a system into simpler, interacting agents, agent-based modeling (ABM) allows researchers to observe the emergence of complex phenomena. High-performance array computing libraries like JAX can help scale such computational models to a large number of agents by using automatic vectorization and just-in-time (JIT) compilation. One of the caveats of using JAX to achieve such scaling is that the shapes of arrays used in the computational model should remain immutable throughout the simulation. In the context of agent-based modeling (ABM), this can pose constraints on certain agent manipulation operations that require flexible data structures. A subset of which is represented by the ability to update a dynamically selected number of agents by applying distinct changes to them during a simulation. To this effect, we introduce ABMax, an ABM framework based on JAX that implements multiple just-in-time (JIT) compilable algorithms to provide this functionality. On the canonical predation model benchmark, ABMax achieves runtime performance comparable to state-of-the-art implementations. Further, we show that this functionality can also be vectorized, making it possible to run many similar agent-based models in parallel. We also present two examples in the form of a traffic-flow model and a financial market model to show the use case of ABMax

Reverse Kullback-Leibler (KL) divergence-based regularization with respect to a fixed reference policy is widely used in modern reinforcement learning to preserve the desired traits of the reference policy and sometimes to promote exploration (using uniform reference policy, known as entropy regularization). Beyond serving as a mere anchor, the reference policy can also be interpreted as encoding prior knowledge about good actions in the environment. In the context of alignment, recent game-theoretic approaches have leveraged KL regularization with pretrained language models as reference policies, achieving notable empirical success in self-play methods. Despite these advances, the theoretical benefits of KL regularization in game-theoretic settings remain poorly understood. In this work, we develop and analyze algorithms that provably achieve improved sample efficiency under KL regularization. We study both two-player zero-sum Matrix games and Markov games: for Matrix games, we propose OMG, an algorithm based on best response sampling with optimistic bonuses, and extend this idea to Markov games through the algorithm SOMG, which also uses best response sampling and a novel concept of superoptimistic bonuses. Both algorithms achieve a logarithmic regret in $T$ that scales inversely with the KL regularization strength $β$ in addition to the standard $\widetilde{\mathcal{O}}(\sqrt{T})$ regret independent of $β$ which is attained in both regularized and unregularized settings

The advent of large language models (LLMs) has enabled agents to represent virtual humans in societal simulations, facilitating diverse interactions within complex social systems. However, existing LLM-based agents exhibit severe limitations in affective cognition: They fail to simulate the bounded rationality essential for bridging virtual and real-world services; They lack empirically validated integration mechanisms embedding emotions within agent decision architectures. This paper constructs an emotional cognition framework incorporating desire generation and objective management, designed to achieve emotion alignment between LLM-based agents and humans, modeling the complete decision-making process of LLM-based agents, encompassing state evolution, desire generation, objective optimization, decision generation, and action execution. This study implements the proposed framework within our proprietary multi-agent interaction environment. Experimental results demonstrate that agents governed by our framework not only exhibit behaviors congruent with their emotional states but also, in comparative assessments against other agent types, demonstrate superior ecological validity and generate decision outcomes that significantly more closely approximate human behavioral patterns.

Autonomous robots deployed in shared human environments, such as agricultural settings, require rigorous safety assurance to meet both functional reliability and regulatory compliance. These systems must operate in dynamic, unstructured environments, interact safely with humans, and respond effectively to a wide range of potential hazards. This paper presents a verification workflow for the safety assurance of an autonomous agricultural robot, covering the entire development life-cycle, from concept study and design to runtime verification. The outlined methodology begins with a systematic hazard analysis and risk assessment to identify potential risks and derive corresponding safety requirements. A formal model of the safety controller is then developed to capture its behaviour and verify that the controller satisfies the specified safety properties with respect to these requirements. The proposed approach is demonstrated on a field robot operating in an agricultural setting. The results show that the methodology can be effectively used to verify safety-critical properties and facilitate the early identification of design issues, contributing to the development of safer robots and autonomous systems.

Computer-use agents (CUAs) promise to automate complex tasks across operating systems (OS) and the web, but remain vulnerable to indirect prompt injection. Current evaluations of this threat either lack support realistic but controlled environments or ignore hybrid web-OS attack scenarios involving both interfaces. To address this, we propose RedTeamCUA, an adversarial testing framework featuring a novel hybrid sandbox that integrates a VM-based OS environment with Docker-based web platforms. Our sandbox supports key features tailored for red teaming, such as flexible adversarial scenario configuration, and a setting that decouples adversarial evaluation from navigational limitations of CUAs by initializing tests directly at the point of an adversarial injection. Using RedTeamCUA, we develop RTC-Bench, a comprehensive benchmark with 864 examples that investigate realistic, hybrid web-OS attack scenarios and fundamental security vulnerabilities. Benchmarking current frontier CUAs identifies significant vulnerabilities: Claude 3.7 Sonnet | CUA demonstrates an ASR of 42.9%, while Operator, the most secure CUA evaluated, still exhibits an ASR of 7.6%. Notably, CUAs often attempt to execute adversarial tasks with an Attempt Rate as high as 92.5%, although failing to complete them due to capability limitations. Nevertheless, we observe concerning high ASRs in realistic end-to-end settings, with the strongest-to-date Claude 4.5 Sonnet | CUA exhibiting the highest ASR of 60%, indicating that CUA threats can already result in tangible risks to users and computer systems. Overall, RedTeamCUA provides an essential framework for advancing realistic, controlled, and systematic analysis of CUA vulnerabilities, highlighting the urgent need for robust defenses to indirect prompt injection prior to real-world deployment.