Multimodal text-to-image generation remains constrained by the difficulty of maintaining semantic alignment and professional-level detail across diverse visual domains. We propose a multi-agent reinforcement learning framework that coordinates domain-specialized agents (e.g., focused on architecture, portraiture, and landscape imagery) within two coupled subsystems: a text enhancement module and an image generation module, each augmented with multimodal integration components. Agents are trained using Proximal Policy Optimization (PPO) under a composite reward function that balances semantic similarity, linguistic visual quality, and content diversity. Cross-modal alignment is enforced through contrastive learning, bidirectional attention, and iterative feedback between text and image. Across six experimental settings, our system significantly enriches generated content (word count increased by 1614%) while reducing ROUGE-1 scores by 69.7%. Among fusion methods, Transformer-based strategies achieve the highest composite score (0.521), despite occasional stability issues. Multimodal ensembles yield moderate consistency (ranging from 0.444 to 0.481), reflecting the persistent challenges of cross-modal semantic grounding. These findings underscore the promise of collaborative, specialization-driven architectures for advancing reliable multimodal generative systems.

Recent progress in multi-agent systems highlights the promise of specialized agents that collaborate through a division of labor. In contrast, most tool-augmented reasoning systems still adopt a single-agent paradigm, where one large model must interleave high-level reasoning with fine-grained tool operations--a process that often leads to cognitive-load interference and unstable outputs. We propose MSARL (Multi-Small-Agent Reinforcement Learning), a novel framework that explicitly decouples reasoning from tool execution and interpretation. In MSARL, a dedicated reasoning agent focuses on strategic problem decomposition and planning, while a specialized tool agent processes long and complex tool outputs, acting as an adaptive condenser to bridge information gaps. This role-specific separation not only reduces cognitive interference but also accelerates the information flow. To enable effective collaboration, we introduce a hierarchical reinforcement learning approach that uses role-specific and collaboration-based rewards, providing granular feedback to the tool agent and a holistic, trajectory-level signal to the reasoning agent. On mathematical problem-solving with code execution, MSARL achieves more stable reasoning and higher final-answer accuracy than strong single-agent baselines.

Complex medical decision-making involves cooperative workflows operated by different clinicians. Designing AI multi-agent systems can expedite and augment human-level clinical decision-making. Existing multi-agent researches primarily focus on language-only tasks, yet their extension to multimodal scenarios remains challenging. A blind combination of diverse vision-language models (VLMs) can amplify an erroneous outcome interpretation. VLMs in general are less capable in instruction following and importantly self-reflection, compared to large language models (LLMs) of comparable sizes. This disparity largely constrains VLMs' ability in cooperative workflows. In this study, we propose MedOrch, a mediator-guided multi-agent collaboration framework for medical multimodal decision-making. MedOrch employs an LLM-based mediator agent that enables multiple VLM-based expert agents to exchange and reflect on their outputs towards collaboration. We utilize multiple open-source general-purpose and domain-specific VLMs instead of costly GPT-series models, revealing the strength of heterogeneous models. We show that the collaboration within distinct VLM-based agents can surpass the capabilities of any individual agent. We validate our approach on five medical vision question answering benchmarks, demonstrating superior collaboration performance without model training. Our findings underscore the value of mediator-guided multi-agent collaboration in advancing medical multimodal intelligence.

Effectively interpreting strategic interactions among multiple agents requires us to infer each agent's objective from limited information. Existing inverse game-theoretic approaches frame this challenge in terms of a "level-1" inference problem, in which we take the perspective of a third-party observer and assume that individual agents share complete knowledge of one another's objectives. However, this assumption breaks down in decentralized, real-world scenarios like urban driving and bargaining, in which agents may act based on conflicting views of one another's objectives. We demonstrate the necessity of inferring agents' different estimates of each other's objectives through empirical examples, and by theoretically characterizing the prediction error of level-1 inference on fictitious gameplay data from linear-quadratic games. To address this fundamental issue, we propose a framework for level-2 inference to address the question: "What does each agent believe about other agents' objectives?" We prove that the level-2 inference problem is non-convex even in benign settings like linear-quadratic games, and we develop an efficient gradient-based approach for identifying local solutions. Experiments on a synthetic urban driving example show that our approach uncovers nuanced misalignments that level-1 methods miss.

The rapid proliferation of scientific knowledge presents a grand challenge: transforming this vast repository of information into an active engine for discovery, especially in high-stakes domains like healthcare. Current AI agents, however, are constrained by static, predefined strategies, limiting their ability to navigate the complex, evolving ecosystem of scientific research. This paper introduces HealthFlow, a self-evolving AI agent that overcomes this limitation through a novel meta-level evolution mechanism. HealthFlow autonomously refines its high-level problem-solving policies by distilling procedural successes and failures into a durable, structured knowledge base, enabling it to learn not just how to use tools, but how to strategize. To anchor our research and provide a community resource, we introduce EHRFlowBench, a new benchmark featuring complex health data analysis tasks systematically derived from peer-reviewed scientific literature. Our experiments demonstrate that HealthFlow's self-evolving approach significantly outperforms state-of-the-art agent frameworks. This work offers a new paradigm for intelligent systems that can learn to operationalize the procedural knowledge embedded in scientific content, marking a critical step toward more autonomous and effective AI for healthcare scientific discovery.

Traditionally, neighborhood studies have used interviews, surveys, and manual image annotation guided by detailed protocols to identify environmental characteristics, including physical disorder, decay, street safety, and sociocultural symbols, and to examine their impact on developmental and health outcomes. Although these methods yield rich insights, they are time-consuming and require intensive expert intervention. Recent technological advances, including vision language models (VLMs), have begun to automate parts of this process; however, existing efforts are often ad hoc and lack adaptability across research designs and geographic contexts. In this paper, we present StreetLens, a user-configurable human-centered workflow that integrates relevant social science expertise into a VLM for scalable neighborhood environmental assessments. StreetLens mimics the process of trained human coders by focusing the analysis on questions derived from established interview protocols, retrieving relevant street view imagery (SVI), and generating a wide spectrum of semantic annotations from objective features (e.g., the number of cars) to subjective perceptions (e.g., the sense of disorder in an image). By enabling researchers to define the VLM's role through domain-informed prompting, StreetLens places domain knowledge at the core of the analysis process. It also supports the integration of prior survey data to enhance robustness and expand the range of characteristics assessed in diverse settings. StreetLens represents a shift toward flexible and agentic AI systems that work closely with researchers to accelerate and scale neighborhood studies. StreetLens is publicly available at https://knowledge-computing.github.io/projects/streetlens.

The application of AI in psychiatric diagnosis faces significant challenges, including the subjective nature of mental health assessments, symptom overlap across disorders, and privacy constraints limiting data availability. To address these issues, we present MoodAngels, the first specialized multi-agent framework for mood disorder diagnosis. Our approach combines granular-scale analysis of clinical assessments with a structured verification process, enabling more accurate interpretation of complex psychiatric data. Complementing this framework, we introduce MoodSyn, an open-source dataset of 1,173 synthetic psychiatric cases that preserves clinical validity while ensuring patient privacy. Experimental results demonstrate that MoodAngels outperforms conventional methods, with our baseline agent achieving 12.3% higher accuracy than GPT-4o on real-world cases, and our full multi-agent system delivering further improvements. Evaluation in the MoodSyn dataset demonstrates exceptional fidelity, accurately reproducing both the core statistical patterns and complex relationships present in the original data while maintaining strong utility for machine learning applications. Together, these contributions provide both an advanced diagnostic tool and a critical research resource for computational psychiatry, bridging important gaps in AI-assisted mental health assessment.

Deep multi-agent reinforcement learning (MARL) has been demonstrated effectively in simulations for multi-robot problems. For autonomous vehicles, the development of vehicle-to-vehicle (V2V) communication technologies provide opportunities to further enhance system safety. However, zero-shot transfer of simulator-trained MARL policies to dynamic hardware systems remains challenging, and how to leverage communication and shared information for MARL has limited demonstrations on hardware. This problem is challenged by discrepancies between simulated and physical states, system state and model uncertainties, practical shared information design, and the need for safety guarantees in both simulation and hardware. This paper designs RSR-RSMARL, a novel Robust and Safe MARL framework that supports Real-Sim-Real (RSR) policy adaptation for multi-agent systems with communication among agents, with both simulation and hardware demonstrations. RSR-RSMARL leverages state (includes shared state information among agents) and action representations considering real system complexities for MARL formulation. The MARL policy is trained with robust MARL algorithm to enable zero-shot transfer to hardware considering the sim-to-real gap. A safety shield module using Control Barrier Functions (CBFs) provides safety guarantee for each individual agent. Experimental results on 1/10th-scale autonomous vehicles with V2V communication demonstrate the ability of RSR-RSMARL framework to enhance driving safety and coordination across multiple configurations. These findings emphasize the importance of jointly designing robust policy representations and modular safety architectures to enable scalable, generalizable RSR transfer in multi-agent autonomy.

We propose multi-agent reinforcement learning as a new method for modeling fake news in social networks. This method allows us to model human behavior in social networks both in unaccustomed populations and in populations that have adapted to the presence of fake news. In particular the latter is challenging for existing methods. We find that a fake-news attack is more effective if it targets highly connected people and people with weaker private information. Attacks are more effective when the disinformation is spread across several agents than when the disinformation is concentrated with more intensity on fewer agents. Furthermore, fake news spread less well in balanced networks than in clustered networks. We test a part of our findings in a human-subject experiment. The experimental evidence provides support for the predictions from the model, suggesting that the model is suitable to analyze the spread of fake news in social networks.

We present Operand Quant, a single-agent, IDE-based architecture for autonomous machine learning engineering (MLE). Operand Quant departs from conventional multi-agent orchestration frameworks by consolidating all MLE lifecycle stages -- exploration, modeling, experimentation, and deployment -- within a single, context-aware agent. On the MLE-Benchmark (2025), Operand Quant achieved a new state-of-the-art (SOTA) result, with an overall medal rate of 0.3956 +/- 0.0565 across 75 problems -- the highest recorded performance among all evaluated systems to date. The architecture demonstrates that a linear, non-blocking agent, operating autonomously within a controlled IDE environment, can outperform multi-agent and orchestrated systems under identical constraints.