Rare diseases represent the long tail of medical imaging, where AI models often fail due to the scarcity of representative training data. In clinical workflows, radiologists frequently consult case reports and literature when confronted with unfamiliar findings. Following this line of reasoning, we introduce RADAR, Retrieval Augmented Diagnostic Reasoning Agents, an agentic system for rare disease detection in brain MRI. Our approach uses AI agents with access to external medical knowledge by embedding both case reports and literature using sentence transformers and indexing them with FAISS to enable efficient similarity search. The agent retrieves clinically relevant evidence to guide diagnostic decision making on unseen diseases, without the need of additional training. Designed as a model-agnostic reasoning module, RADAR can be seamlessly integrated with diverse large language models, consistently improving their rare pathology recognition and interpretability. On the NOVA dataset comprising 280 distinct rare diseases, RADAR achieves up to a 10.2% performance gain, with the strongest improvements observed for open source models such as DeepSeek. Beyond accuracy, the retrieved examples provide interpretable, literature grounded explanations, highlighting retrieval-augmented reasoning as a powerful paradigm for low-prevalence conditions in medical imaging.

Abstract--We consider the problem of communication-constrained collaborative personalized mean estimation under a privacy constraint in an environment of several agents continuously receiving data according to arbitrary unknown agent-specific distributions. A consensus-based algorithm is studied under the framework of differential privacy in order to protect each agent's data. We give a theoretical convergence analysis of the proposed consensus-based algorithm for any bounded unknown distributions on the agents' data, showing that collaboration provides faster convergence than a fully local approach where agents do not share data, under an oracle decision rule and under some restrictions on the privacy level and the agents' connectivity, which illustrates the benefit of private collaboration in an online setting under a communication restriction on the agents. The theoretical faster-than-local convergence guarantee is backed up by several numerical results. The interest in collaborative learning has grown considerably recently, fueled by prominent frameworks such as federated learning (FL) [1]-[3], which offers a partially decentralized approach, and fully decentralized methods like swarm learning [4].

School of Computer Science, Carnegie Mellon University, Pittsburgh, P A, USA ABSTRACT Disinformation campaigns can distort public perception and destabilize institutions. Understanding how different populations respond to information is crucial for designing effective interventions, yet real-world experimentation is impractical and ethically challenging. To address this, we develop an agent-based simulation using Large Language Models (LLMs) to model responses to misinformation. We construct agent personas spanning five professions and three mental schemas, and evaluate their reactions to news headlines. Our findings show that LLM-generated agents align closely with ground-truth labels and human predictions, supporting their use as proxies for studying information responses. We also find that mental schemas, more than professional background, influence how agents interpret misinformation. This work provides a validation of LLMs to be used as agents in an agent-based model of an information network for analyzing trust, polarization, and susceptibility to deceptive content in complex social systems. 1 INTRODUCTION Protection against foreign information campaigns and the ability to conduct effective information operations are critical to modern national security. In an era where the information domain can be leveraged as a battlefield, there is a need to maintain information advantage, defined as "the use, protection, and exploitation of information to achieve objectives more effectively than enemies and adversaries do" (U.S. Achieving and sustaining information advantage requires not only the ability to disseminate compelling narratives but also to detect, counter, and mitigate adversarial information operations.

AI researchers have long focused on poker-like games as a testbed for environments characterized by multi-player dynamics, imperfect information, and reasoning under uncertainty. While recent breakthroughs have matched elite human play at no-limit Texas hold'em, the multi-player dynamics are subdued: most hands converge quickly with only two players engaged through multiple rounds of bidding. In this paper, we present Solly, the first AI agent to achieve elite human play in reduced-format Liar's Poker, a game characterized by extensive multi-player engagement. We trained Solly using self-play with a model-free, actor-critic, deep reinforcement learning algorithm. Solly played at an elite human level as measured by win rate (won over 50% of hands) and equity (money won) in heads-up and multi-player Liar's Poker. Solly also outperformed large language models (LLMs), including those with reasoning abilities, on the same metrics. Solly developed novel bidding strategies, randomized play effectively, and was not easily exploitable by world-class human players.

Generative AI (GenAI) has recently emerged as a groundbreaking force in Software Engineering, capable of generating code, identifying bugs, recommending fixes, and supporting quality assurance. While its use in coding tasks shows considerable promise, applying GenAI across the entire Software Development Life Cycle (SDLC) has not yet been fully explored. Critical uncertainties in areas such as reliability, accountability, security, and data privacy demand deeper investigation and coordinated action. The GENIUS project, comprising over 30 European industrial and academic partners, aims to address these challenges by advancing AI integration across all SDLC phases. It focuses on GenAI's potential, the development of innovative tools, and emerging research challenges, actively shaping the future of software engineering. This vision paper presents a shared perspective on the future of GenAI-driven software engineering, grounded in cross-sector dialogue as well as experiences and findings within the GENIUS consortium. The paper explores four central elements: (1) a structured overview of current challenges in GenAI adoption across the SDLC; (2) a forward-looking vision outlining key technological and methodological advances expected over the next five years; (3) anticipated shifts in the roles and required skill sets of software professionals; and (4) the contribution of GENIUS in realising this transformation through practical tools and industrial validation. This paper focuses on aligning technical innovation with business relevance. It aims to inform both research agendas and industrial strategies, providing a foundation for reliable, scalable, and industry-ready GenAI solutions for software engineering teams.

Abstract--Incident management (IM) is central to the reliability of large-scale cloud systems. Y et manual IM, where on-call engineers examine metrics, logs, and traces is labor-intensive and error-prone in the face of massive and heterogeneous observ-ability data. Existing automated IM approaches often struggle to generalize across systems, provide limited interpretability, and incur high deployment costs, which hinders adoption in practice. In this paper, we present OpsAgent, a lightweight, self-evolving multi-agent system for IM that employs a training-free data processor to convert heterogeneous observability data into structured textual descriptions, along with a multi-agent collaboration framework that makes diagnostic inference transparent and auditable. T o support continual capability growth, OpsAgent also introduces a dual self-evolution mechanism that integrates internal model updates with external experience accumulation, thereby closing the deployment loop. Comprehensive experiments on the OPENRCA [1] benchmark demonstrate state-of-the-art performance and show that OpsAgent is generalizable, interpretable, cost-efficient, and self-evolving, making it a practically deployable and sustainable solution for long-term operation in real-world cloud systems. Cloud systems have become the de facto platform for modern software services, with wide deployments across industries such as IT, government, and finance [2]. However, incidents (e.g., service disruptions and outages) [2], [3] are inevitable due to the complexity of cloud systems, often resulting in catastrophic economic and operational consequences. Google Cloud triggered a global outage that lasted nearly eight hours, disrupting more than 80 GCP services and cascading into failures across e-commerce, finance, AI applications, entertainment platforms, and transportation systems worldwide. The economic impact of this incident was substantial, as it encompassed not only Google's direct losses but also widespread hidden costs borne by countless enterprises and end users affected by the disruption [4]. Traditionally, on-call engineers (OCEs) manually inspect metrics, logs, and traces to identify the root cause when incidents occur [2].

AI agents are continually optimized for tasks related to human work, such as software engineering and professional writing, signaling a pressing trend with significant impacts on the human workforce. However, these agent developments have often not been grounded in a clear understanding of how humans execute work, to reveal what expertise agents possess and the roles they can play in diverse workflows. In this work, we study how agents do human work by presenting the first direct comparison of human and agent workers across multiple essential work-related skills: data analysis, engineering, computation, writing, and design. To better understand and compare heterogeneous computer-use activities of workers, we introduce a scalable toolkit to induce interpretable, structured workflows from either human or agent computer-use activities. Using such induced workflows, we compare how humans and agents perform the same tasks and find that: (1) While agents exhibit promise in their alignment to human workflows, they take an overwhelmingly programmatic approach across all work domains, even for open-ended, visually dependent tasks like design, creating a contrast with the UI-centric methods typically used by humans. (2) Agents produce work of inferior quality, yet often mask their deficiencies via data fabrication and misuse of advanced tools. (3) Nonetheless, agents deliver results 88.3% faster and cost 90.4-96.2% less than humans, highlighting the potential for enabling efficient collaboration by delegating easily programmable tasks to agents.

The proliferation of agent frameworks has led to fragmentation in how agents are defined, executed, and evaluated. Existing systems differ in their abstractions, data flow semantics, and tool integrations, making it difficult to share or reproduce workflows. We introduce Open Agent Specification (Agent Spec), a declarative language that defines AI agents and agentic workflows in a way that is compatible across frameworks, promoting reusability, portability and interoperability of AI agents. Agent Spec defines a common set of components, control and data flow semantics, and schemas that allow an agent to be defined once and executed across different runtimes. Agent Spec also introduces a standardized Evaluation harness to assess agent behavior and agentic workflows across runtimes - analogous to how HELM and related harnesses standardized LLM evaluation - so that performance, robustness, and efficiency can be compared consistently across frameworks. We demonstrate this using four distinct runtimes (LangGraph, CrewAI, AutoGen, and WayFlow) evaluated over three different benchmarks (SimpleQA Verified, $τ^2$-Bench and BIRD-SQL). We provide accompanying toolsets: a Python SDK (PyAgentSpec), a reference runtime (WayFlow), and adapters for popular frameworks (e.g., LangGraph, AutoGen, CrewAI). Agent Spec bridges the gap between model-centric and agent-centric standardization & evaluation, laying the groundwork for reliable, reusable, and portable agentic systems.

Smart contracts operate in a highly adversarial environment, where vulnerabilities can lead to substantial financial losses. Thus, smart contracts are subject to security audits. In auditing, proof-of-concept (PoC) exploits play a critical role by demonstrating to the stakeholders that the reported vulnerabilities are genuine, reproducible, and actionable. However, manually creating PoCs is time-consuming, error-prone, and often constrained by tight audit schedules. We introduce POCO, an agentic framework that automatically generates executable PoC exploits from natural-language vulnerability descriptions written by auditors. POCO autonomously generates PoC exploits in an agentic manner by interacting with a set of code-execution tools in a Reason-Act-Observe loop. It produces fully executable exploits compatible with the Foundry testing framework, ready for integration into audit reports and other security tools. We evaluate POCO on a dataset of 23 real-world vulnerability reports. POCO consistently outperforms the prompting and workflow baselines, generating well-formed and logically correct PoCs. Our results demonstrate that agentic frameworks can significantly reduce the effort required for high-quality PoCs in smart contract audits. Our contribution provides readily actionable knowledge for the smart contract security community.

Cooperative multi-agent planning requires agents to make joint decisions with partial information and limited communication. Coordination at the trajectory level often fails, as small deviations in timing or movement cascade into conflicts. Symbolic planning mitigates this challenge by raising the level of abstraction and providing a minimal vocabulary of actions that enable synchronization and collective progress. We present DR. WELL, a decentralized neurosymbolic framework for cooperative multi-agent planning. Cooperation unfolds through a two-phase negotiation protocol: agents first propose candidate roles with reasoning and then commit to a joint allocation under consensus and environment constraints. After commitment, each agent independently generates and executes a symbolic plan for its role without revealing detailed trajectories. Plans are grounded in execution outcomes via a shared world model that encodes the current state and is updated as agents act. By reasoning over symbolic plans rather than raw trajectories, DR. WELL avoids brittle step-level alignment and enables higher-level operations that are reusable, synchronizable, and interpretable. Experiments on cooperative block-push tasks show that agents adapt across episodes, with the dynamic world model capturing reusable patterns and improving task completion rates and efficiency. Experiments on cooperative block-push tasks show that our dynamic world model improves task completion and efficiency through negotiation and self-refinement, trading a time overhead for evolving, more efficient collaboration strategies.