As aresult, full MOBAgames without restrictions are farfrom being mastered by any existing AI system. In this paper, we propose a MOBA AIlearning paradigm that methodologically enables playing full MOBAgames withdeepreinforcementlearning.Specifically,wedevelopacombinationofnovel and existing learning techniques, including curriculum self-play learning, policy distillation, off-policy adaption, multi-head value estimation, and Monte-Carlo tree-search, intraining andplaying alargepoolofheroes,meanwhile addressing thescalabilityissueskillfully.