The 'Impression' section of a radiology report is a critical basis for communication between radiologists and other physicians, and it is typically written by radiologists based on the 'Findings' section. However, writing numerous impressions can be laborious and error-prone for radiologists. Although recent studies have achieved promising results in automatic impression generation using large-scale medical text data for pre-training and fine-tuning pre-trained language models, such models often require substantial amounts of medical text data and have poor generalization performance. While large language models (LLMs) like ChatGPT have shown strong generalization capabilities and performance, their performance in specific domains, such as radiology, remains under-investigated and potentially limited. To address this limitation, we propose ImpressionGPT, which leverages the in-context learning capability of LLMs by constructing dynamic contexts using domain-specific, individualized data. This dynamic prompt approach enables the model to learn contextual knowledge from semantically similar examples from existing data. Additionally, we design an iterative optimization algorithm that performs automatic evaluation on the generated impression results and composes the corresponding instruction prompts to further optimize the model. The proposed ImpressionGPT model achieves state-of-the-art performance on both MIMIC-CXR and OpenI datasets without requiring additional training data or fine-tuning the LLMs. This work presents a paradigm for localizing LLMs that can be applied in a wide range of similar application scenarios, bridging the gap between general-purpose LLMs and the specific language processing needs of various domains.

Tailoring outputs of large language models, such as ChatGPT, to specific user needs remains a challenge despite their impressive generation quality. In this paper, we propose a tri-agent generation pipeline consisting of a generator, an instructor, and an editor to enhance the customization of generated outputs. The generator produces an initial output, the user-specific instructor generates editing instructions, and the editor generates a revised output aligned with user preferences. The inference-only large language model (ChatGPT) serves as both the generator and the editor, while a smaller model acts as the user-specific instructor to guide the generation process toward user needs. The instructor is trained using editor-steered reinforcement learning, leveraging feedback from the large-scale editor model to optimize instruction generation. Experimental results on two abstractive summarization datasets demonstrate the effectiveness of our approach in generating outputs that better fulfill user expectations.

Despite the surprising few-shot performance of in-context learning (ICL), it is still a common practice to randomly sample examples to serve as context. This paper advocates a new principle for ICL: self-adaptive in-context learning. The self-adaption mechanism is introduced to help each sample find an in-context example permutation (i.e., selection and ordering) that can derive the correct prediction, thus maximizing performance. To validate the effectiveness of self-adaptive ICL, we propose a general select-then-rank framework and instantiate it with new selection and ranking algorithms. Upon extensive evaluation on eight different NLP datasets, our self-adaptive ICL method achieves a 40% relative improvement over the common practice setting. Further analysis reveals the enormous potential of self-adaptive ICL that it might be able to close the gap between ICL and finetuning given more advanced algorithms. Our code is released to facilitate future research in this area: https://github.com/Shark-NLP/self-adaptive-ICL

Recent advancements in specialized large-scale architectures for training image and language have profoundly impacted the field of computer vision and natural language processing (NLP). Language models, such as the recent ChatGPT and GPT4 have demonstrated exceptional capabilities in processing, translating, and generating human languages. These breakthroughs have also been reflected in protein research, leading to the rapid development of numerous new methods in a short time, with unprecedented performance. Language models, in particular, have seen widespread use in protein research, as they have been utilized to embed proteins, generate novel ones, and predict tertiary structures. In this book chapter, we provide an overview of the use of protein generative models, reviewing 1) language models for the design of novel artificial proteins, 2) works that use non-Transformer architectures, and 3) applications in directed evolution approaches.

Human evaluation is indispensable and inevitable for assessing the quality of texts generated by machine learning models or written by humans. However, human evaluation is very difficult to reproduce and its quality is notoriously unstable, hindering fair comparisons among different natural language processing (NLP) models and algorithms. Recently, large language models (LLMs) have demonstrated exceptional performance on unseen tasks when only the task instructions are provided. In this paper, we explore if such an ability of the LLMs can be used as an alternative to human evaluation. We present the LLMs with the exact same instructions, samples to be evaluated, and questions used to conduct human evaluation, and then ask the LLMs to generate responses to those questions; we dub this LLM evaluation. We use human evaluation and LLM evaluation to evaluate the texts in two NLP tasks: open-ended story generation and adversarial attacks. We show that the result of LLM evaluation is consistent with the results obtained by expert human evaluation: the texts rated higher by human experts are also rated higher by the LLMs. We also find that the results of LLM evaluation are stable over different formatting of the task instructions and the sampling algorithm used to generate the answer. We are the first to show the potential of using LLMs to assess the quality of texts and discuss the limitations and ethical considerations of LLM evaluation.

Large language models (LLMs) power many state-of-the-art systems in natural language processing. However, these models are extremely computationally expensive, even at inference time, raising the natural question: when is the extra cost of deploying a larger model worth the anticipated boost in capabilities? Better understanding this tradeoff fundamentally could benefit from an inference efficiency metric that is both (i) easily comparable across models from different providers, and (ii) representative of the true cost of running queries in an isolated performance environment. Unfortunately, access to LLMs today is largely restricted to black-box text generation APIs and raw runtimes measured through this interface do not satisfy these desiderata: model providers can apply various software and hardware optimizations orthogonal to the model, and models served on shared infrastructure are susceptible to performance contention. To circumvent these problems, we propose a new metric for comparing inference efficiency across models. This metric puts models on equal footing as though they were served (i) on uniform hardware and software, and (ii) without performance contention. We call this metric the \emph{idealized runtime}, and we propose a methodology to efficiently estimate this metric for autoregressive Transformer models. We also propose cost-aware variants that incorporate the number of accelerators needed to serve the model. Using these metrics, we compare ten state-of-the-art LLMs to provide the first analysis of inference efficiency-capability tradeoffs; we make several observations from this analysis, including the fact that the superior inference runtime performance of certain APIs is often a byproduct of optimizations within the API rather than the underlying model. Our methodology also facilitates the efficient comparison of different software and hardware stacks.

Automatic analysis of customer data for businesses is an area that is of interest to companies. Business to business data is studied rarely in academia due to the sensitive nature of such information. Applying natural language processing can speed up the analysis of prohibitively large sets of data. This paper addresses this subject and applies sentiment analysis, topic modelling and keyword extraction to a B2B data set. We show that accurate sentiment can be extracted from the notes automatically and the notes can be sorted by relevance into different topics. We see that without clear separation topics can lack relevance to a business context.

The zero-shot relation triplet extraction (ZeroRTE) task aims to extract relation triplets from a piece of text with unseen relation types. The seminal work adopts the pre-trained generative model to generate synthetic samples for new relations. However, current generative models lack the optimization process of model generalization on different tasks during training, and thus have limited generalization capability. For this reason, we propose a novel generative meta-learning framework which exploits the `learning-to-learn' ability of meta-learning to boost the generalization capability of generative models. Specifically, we first design a task-aware generative model which can learn the general knowledge by forcing the optimization process to be conducted across multiple tasks. Based on it, we then present three generative meta-learning approaches designated for three typical meta-learning categories. Extensive experimental results demonstrate that our framework achieves a new state-of-the-art performance for the ZeroRTE task.

Communication of scientific findings to the public is important for keeping non-experts informed of developments such as life-saving medical treatments. However, generating readable lay summaries from scientific documents is challenging, and currently, these summaries suffer from critical factual errors. One popular intervention for improving factuality is using additional external knowledge to provide factual grounding. However, it is unclear how these grounding sources should be retrieved, selected, or integrated, and how supplementary grounding documents might affect the readability or relevance of the generated summaries. We develop a simple method for selecting grounding sources and integrating them with source documents. We then use the BioLaySum summarization dataset to evaluate the effects of different grounding sources on summary quality. We found that grounding source documents improves the relevance and readability of lay summaries but does not improve factuality of lay summaries. This continues to be true in zero-shot summarization settings where we hypothesized that grounding might be even more important for factual lay summaries.

Creating programs to correctly manipulate data is a difficult task, as the underlying programming languages and APIs can be challenging to learn for many users who are not skilled programmers. Large language models (LLMs) demonstrate remarkable potential for generating code from natural language, but in the data manipulation domain, apart from the natural language (NL) description of the intended task, we also have the dataset on which the task is to be performed, or the "data context". Existing approaches have utilized data context in a limited way by simply adding relevant information from the input data into the prompts sent to the LLM. In this work, we utilize the available input data to execute the candidate programs generated by the LLMs and gather their outputs. We introduce semantic reranking, a technique to rerank the programs generated by LLMs based on three signals coming the program outputs: (a) semantic filtering and well-formedness based score tuning: do programs even generate well-formed outputs, (b) semantic interleaving: how do the outputs from different candidates compare to each other, and (c) output-based score tuning: how do the outputs compare to outputs predicted for the same task. We provide theoretical justification for semantic interleaving. We also introduce temperature mixing, where we combine samples generated by LLMs using both high and low temperatures. We extensively evaluate our approach in three domains, namely databases (SQL), data science (Pandas) and business intelligence (Excel's Power Query M) on a variety of new and existing benchmarks. We observe substantial gains across domains, with improvements of up to 45% in top-1 accuracy and 34% in top-3 accuracy.