Speech, language, and communication deficits are present in most neurodegenerative syndromes. They enable the early detection, diagnosis, treatment planning, and monitoring of neurocognitive disease progression as part of traditional neurological assessment. Nevertheless, standard speech and language evaluation is time-consuming and resource-intensive for clinicians. We argue that using machine learning methodologies, natural language processing, and modern artificial intelligence (AI) for Language Assessment is an improvement over conventional manual assessment. Using these methodologies, Computational Language Assessment (CLA) accomplishes three goals: (i) provides a neuro-cognitive evaluation of speech, language, and communication in elderly and high-risk individuals for dementia; (ii) facilitates the diagnosis, prognosis, and therapy efficacy in at-risk and language-impaired populations; and (iii) allows easier extensibility to assess patients from a wide range of languages. By employing AI models, CLA may inform neurocognitive theory on the relationship between language symptoms and their neural bases. Finally, it signals a paradigm shift by significantly advancing our ability to optimize the prevention and treatment of elderly individuals with communication disorders, allowing them to age gracefully with social engagement.

In this study, we introduce a learning-based method for generating high-quality human motion sequences from text descriptions (e.g., ``A person walks forward"). Existing techniques struggle with motion diversity and smooth transitions in generating arbitrary-length motion sequences, due to limited text-to-motion datasets and the pose representations used that often lack expressiveness or compactness. To address these issues, we propose the first method for text-conditioned human motion generation in the frequency domain of motions. We develop a network encoder that converts the motion space into a compact yet expressive parameterized phase space with high-frequency details encoded, capturing the local periodicity of motions in time and space with high accuracy. We also introduce a conditional diffusion model for predicting periodic motion parameters based on text descriptions and a start pose, efficiently achieving smooth transitions between motion sequences associated with different text descriptions. Experiments demonstrate that our approach outperforms current methods in generating a broader variety of high-quality motions, and synthesizing long sequences with natural transitions.

Predicting protein stability changes induced by single-point mutations has been a persistent challenge over the years, attracting immense interest from numerous researchers. The ability to precisely predict protein thermostability is pivotal for various subfields and applications in biochemistry, including drug development, protein evolution analysis, and enzyme synthesis. Despite the proposition of multiple methodologies aimed at addressing this issue, few approaches have successfully achieved optimal performance coupled with high computational efficiency. Two principal hurdles contribute to the existing challenges in this domain. The first is the complexity of extracting and aggregating sufficiently representative features from proteins. The second refers to the limited availability of experimental data for protein mutation analysis, further complicating the comprehensive evaluation of model performance on unseen data samples. With the advent of Large Language Models(LLM), such as the ESM models in protein research, profound interpretation of protein features is now accessibly aided by enormous training data. Therefore, LLMs are indeed to facilitate a wide range of protein research. In our study, we introduce an ESM-assisted efficient approach that integrates protein sequence and structural features to predict the thermostability changes in protein upon single-point mutations. Furthermore, we have curated a dataset meticulously designed to preclude data leakage, corresponding to two extensively employed test datasets, to facilitate a more equitable model comparison.

Entity resolution (ER) is an important data integration task with a wide spectrum of applications. The state-of-the-art solutions on ER rely on pre-trained language models (PLMs), which require fine-tuning on a lot of labeled matching/non-matching entity pairs. Recently, large languages models (LLMs), such as GPT-4, have shown the ability to perform many tasks without tuning model parameters, which is known as in-context learning (ICL) that facilitates effective learning from a few labeled input context demonstrations. However, existing ICL approaches to ER typically necessitate providing a task description and a set of demonstrations for each entity pair and thus have limitations on the monetary cost of interfacing LLMs. To address the problem, in this paper, we provide a comprehensive study to investigate how to develop a cost-effective batch prompting approach to ER. We introduce a framework BATCHER consisting of demonstration selection and question batching and explore different design choices that support batch prompting for ER. We also devise a covering-based demonstration selection strategy that achieves an effective balance between matching accuracy and monetary cost. We conduct a thorough evaluation to explore the design space and evaluate our proposed strategies. Through extensive experiments, we find that batch prompting is very cost-effective for ER, compared with not only PLM-based methods fine-tuned with extensive labeled data but also LLM-based methods with manually designed prompting. We also provide guidance for selecting appropriate design choices for batch prompting.

Medical report generation demands automatic creation of coherent and precise descriptions for medical images. However, the scarcity of labelled medical image-report pairs poses formidable challenges in developing large-scale neural networks capable of harnessing the potential of artificial intelligence, exemplified by large language models. This study builds upon the state-of-the-art vision-language pre-training and fine-tuning approach, BLIP-2, to customize general large-scale foundation models. Integrating adapter tuning and a medical knowledge enhancement loss, our model significantly improves accuracy and coherence. Validation on the dataset of ImageCLEFmedical 2023 demonstrates our model's prowess, achieving the best-averaged results against several state-of-the-art methods. Significant improvements in ROUGE and CIDEr underscore our method's efficacy, highlighting promising outcomes for the rapid medical-domain adaptation of the vision-language foundation models in addressing challenges posed by data scarcity.

Natural language supervision has been shown to be effective for zero-shot learning in many computer vision tasks, such as object detection and activity recognition. However, generating informative prompts can be challenging for more subtle tasks, such as video content moderation. This can be difficult, as there are many reasons why a video might be inappropriate, beyond violence and obscenity. For example, scammers may attempt to create junk content that is similar to popular educational videos but with no meaningful information. This paper evaluates the performance of several CLIP variations for content moderation of children's cartoons in both the supervised and zero-shot setting. We show that our proposed model (Vanilla CLIP with Projection Layer) outperforms previous work conducted on the Malicious or Benign (MOB) benchmark for video content moderation. This paper presents an in depth analysis of how context-specific language prompts affect content moderation performance. Our results indicate that it is important to include more context in content moderation prompts, particularly for cartoon videos as they are not well represented in the CLIP training data.

We explore the viability of casting foundation models as generic reward functions for reinforcement learning. To this end, we propose a simple pipeline that interfaces an off-the-shelf vision model with a large language model. Specifically, given a trajectory of observations, we infer the likelihood of an instruction describing the task that the user wants an agent to perform. We show that this generic likelihood function exhibits the characteristics ideally expected from a reward function: it associates high values with the desired behaviour and lower values for several similar, but incorrect policies. Overall, our work opens the possibility of designing open-ended agents for interactive tasks via foundation models.

This document serves as an overview of the different mechanisms and areas of governance in the BigCode project. It aims to support transparency by providing relevant information about choices that were made during the project to the broader public, and to serve as an example of intentional governance of an open research project that future endeavors can leverage to shape their own approach. The first section, Project Structure, covers the project organization, its stated goals and values, its internal decision processes, and its funding and resources. The second section, Data and Model Governance, covers decisions relating to the questions of data subject consent, privacy, and model release.

This year, we witnessed a rise in the use of Large Language Models, especially when combined with applications like chatbot assistants. Safety mechanisms and specialized training procedures are put in place to prevent improper responses from these assistants. In this work, we bypass these measures for ChatGPT and Bard (and, to some extent, Bing chat) by making them impersonate complex personas with opposite characteristics as those of the truthful assistants they are supposed to be. We start by creating elaborate biographies of these personas, which we then use in a new session with the same chatbots. Our conversation followed a role-play style to get the response the assistant was not allowed to provide. By making use of personas, we show that the response that is prohibited is actually provided, making it possible to obtain unauthorized, illegal, or harmful information. This work shows that by using adversarial personas, one can overcome safety mechanisms set out by ChatGPT and Bard. It also introduces several ways of activating such adversarial personas, altogether showing that both chatbots are vulnerable to this kind of attack.

Recent work in activation steering has demonstrated the potential to better control the outputs of Large Language Models (LLMs), but it involves finding steering vectors. This is difficult because engineers do not typically know how features are represented in these models. We seek to address this issue by applying the idea of mean-centring to steering vectors. We find that taking the average of activations associated with a target dataset, and then subtracting the mean of all training activations, results in effective steering vectors. We test this method on a variety of models on natural language tasks by steering away from generating toxic text, and steering the completion of a story towards a target genre. We also apply mean-centring to extract function vectors, more effectively triggering the execution of a range of natural language tasks by a significant margin (compared to previous baselines). This suggests that mean-centring can be used to easily improve the effectiveness of activation steering in a wide range of contexts.