We propose ProtLLM, a versatile cross-modal large language model (LLM) for both protein-centric and protein-language tasks. ProtLLM features a unique dynamic protein mounting mechanism, enabling it to handle complex inputs where the natural language text is interspersed with an arbitrary number of proteins. Besides, we propose the protein-as-word language modeling approach to train ProtLLM. By developing a specialized protein vocabulary, we equip the model with the capability to predict not just natural language but also proteins from a vast pool of candidates. Additionally, we construct a large-scale interleaved protein-text dataset, named InterPT, for pre-training. This dataset comprehensively encompasses both (1) structured data sources like protein annotations and (2) unstructured data sources like biological research papers, thereby endowing ProtLLM with crucial knowledge for understanding proteins. We evaluate ProtLLM on classic supervised protein-centric tasks and explore its novel protein-language applications. Experimental results demonstrate that ProtLLM not only achieves superior performance against protein-specialized baselines on protein-centric tasks but also induces zero-shot and in-context learning capabilities on protein-language tasks.

Foundation models are powerful technologies: how they are released publicly directly shapes their societal impact. In this position paper, we focus on open foundation models, defined here as those with broadly available model weights (e.g. Llama 2, Stable Diffusion XL). We identify five distinctive properties (e.g. greater customizability, poor monitoring) of open foundation models that lead to both their benefits and risks. Open foundation models present significant benefits, with some caveats, that span innovation, competition, the distribution of decision-making power, and transparency. To understand their risks of misuse, we design a risk assessment framework for analyzing their marginal risk. Across several misuse vectors (e.g. cyberattacks, bioweapons), we find that current research is insufficient to effectively characterize the marginal risk of open foundation models relative to pre-existing technologies. The framework helps explain why the marginal risk is low in some cases, clarifies disagreements about misuse risks by revealing that past work has focused on different subsets of the framework with different assumptions, and articulates a way forward for more constructive debate. Overall, our work helps support a more grounded assessment of the societal impact of open foundation models by outlining what research is needed to empirically validate their theoretical benefits and risks.

Recent studies demonstrate that query expansions generated by large language models (LLMs) can considerably enhance information retrieval systems by generating hypothetical documents that answer the queries as expansions. However, challenges arise from misalignments between the expansions and the retrieval corpus, resulting in issues like hallucinations and outdated information due to the limited intrinsic knowledge of LLMs. Inspired by Pseudo Relevance Feedback (PRF), we introduce Corpus-Steered Query Expansion (CSQE) to promote the incorporation of knowledge embedded within the corpus. CSQE utilizes the relevance assessing capability of LLMs to systematically identify pivotal sentences in the initially-retrieved documents. These corpus-originated texts are subsequently used to expand the query together with LLM-knowledge empowered expansions, improving the relevance prediction between the query and the target documents. Extensive experiments reveal that CSQE exhibits strong performance without necessitating any training, especially with queries for which LLMs lack knowledge.

The introduction of large language models has significantly advanced code generation. However, open-source models often lack the execution capabilities and iterative refinement of advanced systems like the GPT-4 Code Interpreter. To address this, we introduce OpenCodeInterpreter, a family of open-source code systems designed for generating, executing, and iteratively refining code. Supported by Code-Feedback, a dataset featuring 68K multi-turn interactions, OpenCodeInterpreter integrates execution and human feedback for dynamic code refinement. Our comprehensive evaluation of OpenCodeInterpreter across key benchmarks such as HumanEval, MBPP, and their enhanced versions from EvalPlus reveals its exceptional performance. Notably, OpenCodeInterpreter-33B achieves an accuracy of 83.2 (76.4) on the average (and plus versions) of HumanEval and MBPP, closely rivaling GPT-4's 84.2 (76.2) and further elevates to 91.6 (84.6) with synthesized human feedback from GPT-4. OpenCodeInterpreter brings the gap between open-source code generation models and proprietary systems like GPT-4 Code Interpreter.

Modern neural network architectures still struggle to learn algorithmic procedures that require to systematically apply compositional rules to solve out-of-distribution problem instances. In this work, we propose an original approach to learn algorithmic tasks inspired by rewriting systems, a classic framework in symbolic artificial intelligence. We show that a rewriting system can be implemented as a neural architecture composed by specialized modules: the Selector identifies the target sub-expression to process, the Solver simplifies the sub-expression by computing the corresponding result, and the Combiner produces a new version of the original expression by replacing the sub-expression with the solution provided. We evaluate our model on three types of algorithmic tasks that require simplifying symbolic formulas involving lists, arithmetic, and algebraic expressions. We test the extrapolation capabilities of the proposed architecture using formulas involving a higher number of operands and nesting levels than those seen during training, and we benchmark its performance against the Neural Data Router, a recent model specialized for systematic generalization, and a state-of-the-art large language model (GPT-4) probed with advanced prompting strategies.

Decision-making is a fundamental capability in everyday life. Large Language Models (LLMs) provide multifaceted support in enhancing human decision-making processes. However, understanding the influencing factors of LLM-assisted decision-making is crucial for enabling individuals to utilize LLM-provided advantages and minimize associated risks in order to make more informed and better decisions. This study presents the results of a comprehensive literature analysis, providing a structural overview and detailed analysis of determinants impacting decision-making with LLM support. In particular, we explore the effects of technological aspects of LLMs, including transparency and prompt engineering, psychological factors such as emotions and decision-making styles, as well as decision-specific determinants such as task difficulty and accountability. In addition, the impact of the determinants on the decision-making process is illustrated via multiple application scenarios. Drawing from our analysis, we develop a dependency framework that systematizes possible interactions in terms of reciprocal interdependencies between these determinants. Our research reveals that, due to the multifaceted interactions with various determinants, factors such as trust in or reliance on LLMs, the user's mental model, and the characteristics of information processing are identified as significant aspects influencing LLM-assisted decision-making processes. Our findings can be seen as crucial for improving decision quality in human-AI collaboration, empowering both users and organizations, and designing more effective LLM interfaces. Additionally, our work provides a foundation for future empirical investigations on the determinants of decision-making assisted by LLMs.

Many important tasks within multilingual NLP, such as quality estimation, automatic postedition, or grammatical error correction, involve analyzing, generating or operating with text in multiple languages, and are relevant to various translation workflows -- we call these translation-related tasks. Recently, general-purpose large language models (LLMs) challenged the paradigm of per-task dedicated systems, achieving state-of-the-art performance on several recent WMT shared tasks (Kocmi et al., 2023; Freitag et al., 2023; Neves et al., 2023). Unfortunately, strong capabilities for multiple translation-related tasks have so far been exhibited by closed LLMs only (Hendy et al., 2023; Kocmi & Federmann, 2023; Fernandes et al., 2023; Raunak et al., 2023). Perhaps because most open LLMs are English-centric, approaches leveraging these models still lag behind, having thus far achieved competitive results only when specializing on a single task (Xu et al., 2024a; 2023; Iyer et al., 2023). In this paper, we bridge this gap with a detailed recipe to develop an LLM for multiple translation-related tasks. Our approach, illustrated in Figure 1 and inspired by Xu et al.

It is often desirable for Large Language Models (LLMs) to capture multiple objectives when providing a response. In document-grounded response generation, for example, agent responses are expected to be relevant to a user's query while also being grounded in a given document. In this paper, we introduce Proxy Metric-based Self-Refinement (ProMiSe), which enables an LLM to refine its own initial response along key dimensions of quality guided by external metrics feedback, yielding an overall better final response. ProMiSe leverages feedback on response quality through principle-specific proxy metrics, and iteratively refines its response one principle at a time. We apply ProMiSe to open source language models Flan-T5-XXL and Llama-2-13B-Chat, to evaluate its performance on document-grounded question answering datasets, MultiDoc2Dial and QuAC, demonstrating that self-refinement improves response quality. We further show that fine-tuning Llama-2-13B-Chat on the synthetic dialogue data generated by ProMiSe yields significant performance improvements over the zero-shot baseline as well as a supervised fine-tuned model on human annotated data.

Large language models (LLMs) can label data faster and cheaper than humans for various NLP tasks. Despite their prowess, LLMs may fall short in understanding of complex, sociocultural, or domain-specific context, potentially leading to incorrect annotations. Therefore, we advocate a collaborative approach where humans and LLMs work together to produce reliable and high-quality labels. We present MEGAnno+, a human-LLM collaborative annotation system that offers effective LLM agent and annotation management, convenient and robust LLM annotation, and exploratory verification of LLM labels by humans.

Given the accelerating progress of vision and language modeling, accurate evaluation of machine-generated image captions remains critical. In order to evaluate captions more closely to human preferences, metrics need to discriminate between captions of varying quality and content. However, conventional metrics fail short of comparing beyond superficial matches of words or embedding similarities; thus, they still need improvement. This paper presents VisCE$^2$, a vision language model-based caption evaluation method. Our method focuses on visual context, which refers to the detailed content of images, including objects, attributes, and relationships. By extracting and organizing them into a structured format, we replace the human-written references with visual contexts and help VLMs better understand the image, enhancing evaluation performance. Through meta-evaluation on multiple datasets, we validated that VisCE$^2$ outperforms the conventional pre-trained metrics in capturing caption quality and demonstrates superior consistency with human judgment.