Existing X-ray based pre-trained vision models are usually conducted on a relatively small-scale dataset (less than 500k samples) with limited resolution (e.g., 224 $\times$ 224). However, the key to the success of self-supervised pre-training large models lies in massive training data, and maintaining high resolution in the field of X-ray images is the guarantee of effective solutions to difficult miscellaneous diseases. In this paper, we address these issues by proposing the first high-definition (1280 $\times$ 1280) X-ray based pre-trained foundation vision model on our newly collected large-scale dataset which contains more than 1 million X-ray images. Our model follows the masked auto-encoder framework which takes the tokens after mask processing (with a high rate) is used as input, and the masked image patches are reconstructed by the Transformer encoder-decoder network. More importantly, we introduce a novel context-aware masking strategy that utilizes the chest contour as a boundary for adaptive masking operations. We validate the effectiveness of our model on two downstream tasks, including X-ray report generation and disease recognition. Extensive experiments demonstrate that our pre-trained medical foundation vision model achieves comparable or even new state-of-the-art performance on downstream benchmark datasets. The source code and pre-trained models of this paper will be released on https://github.com/Event-AHU/Medical_Image_Analysis.

The creation of a Software Requirements Specification (SRS) document is important for any software development project. Given the recent prowess of Large Language Models (LLMs) in answering natural language queries and generating sophisticated textual outputs, our study explores their capability to produce accurate, coherent, and structured drafts of these documents to accelerate the software development lifecycle. We assess the performance of GPT-4 and CodeLlama in drafting an SRS for a university club management system and compare it against human benchmarks using eight distinct criteria. Our results suggest that LLMs can match the output quality of an entry-level software engineer to generate an SRS, delivering complete and consistent drafts. We also evaluate the capabilities of LLMs to identify and rectify problems in a given requirements document. Our experiments indicate that GPT-4 is capable of identifying issues and giving constructive feedback for rectifying them, while CodeLlama's results for validation were not as encouraging. We repeated the generation exercise for four distinct use cases to study the time saved by employing LLMs for SRS generation. The experiment demonstrates that LLMs may facilitate a significant reduction in development time for entry-level software engineers. Hence, we conclude that the LLMs can be gainfully used by software engineers to increase productivity by saving time and effort in generating, validating and rectifying software requirements.

Accurate representation of medical information is crucial for patient safety, yet artificial intelligence (AI) systems, such as Large Language Models (LLMs), encounter challenges in error-free clinical text interpretation. This paper presents a novel approach submitted to the MEDIQA-CORR 2024 shared task (Ben Abacha et al., 2024a), focusing on the automatic correction of single-word errors in clinical notes. Unlike LLMs that rely on extensive generic data, our method emphasizes extracting contextually relevant information from available clinical text data. Leveraging an ensemble of extractive and abstractive question-answering approaches, we construct a supervised learning framework with domain-specific feature engineering. Our methodology incorporates domain expertise to enhance error correction accuracy. By integrating domain expertise and prioritizing meaningful information extraction, our approach underscores the significance of a human-centric strategy in adapting AI for healthcare.

Dialogue relation extraction (DRE) aims to extract relations between two arguments within a dialogue, which is more challenging than standard RE due to the higher person pronoun frequency and lower information density in dialogues. However, existing DRE methods still suffer from two serious issues: (1) hard to capture long and sparse multi-turn information, and (2) struggle to extract golden relations based on partial dialogues, which motivates us to discover more effective methods that can alleviate the above issues. We notice that the rise of large language models (LLMs) has sparked considerable interest in evaluating their performance across diverse tasks. To this end, we initially investigate the capabilities of different LLMs in DRE, considering both proprietary models and open-source models. Interestingly, we discover that LLMs significantly alleviate two issues in existing DRE methods. Generally, we have following findings: (1) scaling up model size substantially boosts the overall DRE performance and achieves exceptional results, tackling the difficulty of capturing long and sparse multi-turn information; (2) LLMs encounter with much smaller performance drop from entire dialogue setting to partial dialogue setting compared to existing methods; (3) LLMs deliver competitive or superior performances under both full-shot and few-shot settings compared to current state-of-the-art; (4) LLMs show modest performances on inverse relations but much stronger improvements on general relations, and they can handle dialogues of various lengths especially for longer sequences.

Large Language Models(LLMs) have had a profound impact on AI applications, particularly in the domains of long-text comprehension and generation. After that, the part of V Cache will be copied to the CPU asynchronously, while releasing the GPU memory occupied by this part of the V Cache. During decode phase, K states will be pushed and pulled as KV Cache. However, we will calculate the topN of attention scores, and based on the indices of the topN results, we will pull the corresponding V Cache from the CPU to the HBM in real-time to complete the subsequent computation. Through this simple approach, leveraging the structural characteristics of Transformer models, we effectively utilize the idle CPU memory, increasing the capacity of HBM. In this paper, we build InferenceEngine based on KCache that efficiently reduces the memory footprint during LLM inference, which achieved 40% increased throughput and keeping accuracy.

Large-scale language models (LLMs) have achieved remarkable success across various language tasks but suffer from hallucinations and temporal misalignment. To mitigate these shortcomings, Retrieval-augmented generation (RAG) has been utilized to provide external knowledge to facilitate the answer generation. However, applying such models to the medical domain faces several challenges due to the lack of domain-specific knowledge and the intricacy of real-world scenarios. In this study, we explore LLMs with RAG framework for knowledge-intensive tasks in the medical field. To evaluate the capabilities of LLMs, we introduce MedicineQA, a multi-round dialogue benchmark that simulates the real-world medication consultation scenario and requires LLMs to answer with retrieved evidence from the medicine database. MedicineQA contains 300 multi-round question-answering pairs, each embedded within a detailed dialogue history, highlighting the challenge posed by this knowledge-intensive task to current LLMs. We further propose a new \textit{Distill-Retrieve-Read} framework instead of the previous \textit{Retrieve-then-Read}. Specifically, the distillation and retrieval process utilizes a tool calling mechanism to formulate search queries that emulate the keyword-based inquiries used by search engines. With experimental results, we show that our framework brings notable performance improvements and surpasses the previous counterparts in the evidence retrieval process in terms of evidence retrieval accuracy. This advancement sheds light on applying RAG to the medical domain.

Relation extraction (RE) is an important task that aims to identify the relationships between entities in texts. While large language models (LLMs) have revealed remarkable in-context learning (ICL) capability for general zero and few-shot learning, recent studies indicate that current LLMs still struggle with zero and few-shot RE. Previous studies are mainly dedicated to design prompt formats and select good examples for improving ICL-based RE. Although both factors are vital for ICL, if one can fundamentally boost the ICL capability of LLMs in RE, the zero and few-shot RE performance via ICL would be significantly improved. To this end, we introduce \textsc{Micre} (\textbf{M}eta \textbf{I}n-\textbf{C}ontext learning of LLMs for \textbf{R}elation \textbf{E}xtraction), a new meta-training framework for zero and few-shot RE where an LLM is tuned to do ICL on a diverse collection of RE datasets (i.e., learning to learn in context for RE). Through meta-training, the model becomes more effectively to learn a new RE task in context by conditioning on a few training examples with no parameter updates or task-specific templates at inference time, enabling better zero and few-shot task generalization. We experiment \textsc{Micre} on various LLMs with different model scales and 12 public RE datasets, and then evaluate it on unseen RE benchmarks under zero and few-shot settings. \textsc{Micre} delivers comparable or superior performance compared to a range of baselines including supervised fine-tuning and typical in-context learning methods. We find that the gains are particular significant for larger model scales, and using a diverse set of the meta-training RE datasets is key to improvements. Empirically, we show that \textsc{Micre} can transfer the relation semantic knowledge via relation label name during inference on target RE datasets.

The introduction of genome engineering technology has transformed biomedical research, making it possible to make precise changes to genetic information. However, creating an efficient gene-editing system requires a deep understanding of CRISPR technology, and the complex experimental systems under investigation. While Large Language Models (LLMs) have shown promise in various tasks, they often lack specific knowledge and struggle to accurately solve biological design problems. In this work, we introduce CRISPR-GPT, an LLM agent augmented with domain knowledge and external tools to automate and enhance the design process of CRISPR-based gene-editing experiments. CRISPR-GPT leverages the reasoning ability of LLMs to facilitate the process of selecting CRISPR systems, designing guide RNAs, recommending cellular delivery methods, drafting protocols, and designing validation experiments to confirm editing outcomes. We showcase the potential of CRISPR-GPT for assisting non-expert researchers with gene-editing experiments from scratch and validate the agent's effectiveness in a real-world use case. Furthermore, we explore the ethical and regulatory considerations associated with automated gene-editing design, highlighting the need for responsible and transparent use of these tools. Our work aims to bridge the gap between beginner biological researchers and CRISPR genome engineering techniques, and demonstrate the potential of LLM agents in facilitating complex biological discovery tasks.

Humans excel at forming mental maps of their surroundings, equipping them to understand object relationships and navigate based on language queries. Our previous work SI Maps [1] showed that having instance-level information and the semantic understanding of an environment helps significantly improve performance for language-guided tasks. We extend this instance-level approach to 3D while increasing the pipeline's robustness and improving quantitative and qualitative results. Our method leverages foundational models for object recognition, image segmentation, and feature extraction. We propose a representation that results in a 3D point cloud map with instance-level embeddings, which bring in the semantic understanding that natural language commands can query. Quantitatively, the work improves upon the success rate of language-guided tasks. At the same time, we qualitatively observe the ability to identify instances more clearly and leverage the foundational models and language and image-aligned embeddings to identify objects that, otherwise, a closed-set approach wouldn't be able to identify.

Agents based on large language models (LLMs) have demonstrated effectiveness in solving a wide range of tasks by integrating LLMs with key modules such as planning, memory, and tool usage. Increasingly, customers are adopting LLM agents across a variety of commercial applications critical to reliability, including support for mental well-being, chemical synthesis, and software development. Nevertheless, our observations and daily use of LLM agents indicate that they are prone to making erroneous plans, especially when the tasks are complex and require long-term planning. In this paper, we propose PDoctor, a novel and automated approach to testing LLM agents and understanding their erroneous planning. As the first work in this direction, we formulate the detection of erroneous planning as a constraint satisfiability problem: an LLM agent's plan is considered erroneous if its execution violates the constraints derived from the user inputs. To this end, PDoctor first defines a domain-specific language (DSL) for user queries and synthesizes varying inputs with the assistance of the Z3 constraint solver. These synthesized inputs are natural language paragraphs that specify the requirements for completing a series of tasks. Then, PDoctor derives constraints from these requirements to form a testing oracle. We evaluate PDoctor with three mainstream agent frameworks and two powerful LLMs (GPT-3.5 and GPT-4). The results show that PDoctor can effectively detect diverse errors in agent planning and provide insights and error characteristics that are valuable to both agent developers and users. We conclude by discussing potential alternative designs and directions to extend PDoctor.