Merging Large Language Models (LLMs) is a cost-effective technique for combining multiple expert LLMs into a single versatile model, retaining the expertise of the original ones. However, current approaches often overlook the importance of safety alignment during merging, leading to highly misaligned models. This work investigates the effects of model merging on alignment. We evaluate several popular model merging techniques, demonstrating that existing methods do not only transfer domain expertise but also propagate misalignment. We propose a simple two-step approach to address this problem: (i) generating synthetic safety and domain-specific data, and (ii) incorporating these generated data into the optimization process of existing data-aware model merging techniques. This allows us to treat alignment as a skill that can be maximized in the resulting merged LLM. Our experiments illustrate the effectiveness of integrating alignment-related data during merging, resulting in models that excel in both domain expertise and alignment.

Electronic Medical Records (EMRs), while integral to modern healthcare, present challenges for clinical reasoning and diagnosis due to their complexity and information redundancy. To address this, we proposed medIKAL (Integrating Knowledge Graphs as Assistants of LLMs), a framework that combines Large Language Models (LLMs) with knowledge graphs (KGs) to enhance diagnostic capabilities. medIKAL assigns weighted importance to entities in medical records based on their type, enabling precise localization of candidate diseases within KGs. It innovatively employs a residual network-like approach, allowing initial diagnosis by the LLM to be merged into KG search results. Through a path-based reranking algorithm and a fill-in-the-blank style prompt template, it further refined the diagnostic process. We validated medIKAL's effectiveness through extensive experiments on a newly introduced open-sourced Chinese EMR dataset, demonstrating its potential to improve clinical diagnosis in real-world settings.

We conceptualize the process of understanding as information compression, and propose a method for ranking large language models (LLMs) based on lossless data compression. We demonstrate the equivalence of compression length under arithmetic coding with cumulative negative log probabilities when using a large language model as a prior, that is, the pre-training phase of the model is essentially the process of learning the optimal coding length. At the same time, the evaluation metric compression ratio can be obtained without actual compression, which greatly saves overhead. In this paper, we use five large language models as priors for compression, then compare their performance on challenging natural language processing tasks, including sentence completion, question answering, and coreference resolution. Experimental results show that compression ratio and model performance are positively correlated, so it can be used as a general metric to evaluate large language models.

Factual consistency is an important quality in dialogue summarization. Large language model (LLM)-based automatic text summarization models generate more factually consistent summaries compared to those by smaller pretrained language models, but they face deployment challenges in real-world applications due to privacy or resource constraints. In this paper, we investigate the use of symbolic knowledge distillation to improve the factual consistency of smaller pretrained models for dialogue summarization. We employ zero-shot learning to extract symbolic knowledge from LLMs, generating both factually consistent (positive) and inconsistent (negative) summaries. We then apply two contrastive learning objectives on these summaries to enhance smaller summarization models. Experiments with BART, PEGASUS, and Flan-T5 indicate that our approach surpasses strong baselines that rely on complex data augmentation strategies. Our approach achieves better factual consistency while maintaining coherence, fluency, and relevance, as confirmed by various automatic evaluation metrics. We also provide access to the data and code to facilitate future research.

The rapid adoption of online chatbots represents a significant advancement in artificial intelligence. However, this convenience brings considerable privacy concerns, as prompts can inadvertently contain sensitive information exposed to large language models (LLMs). Limited by high computational costs, reduced task usability, and excessive system modifications, previous works based on local deployment, embedding perturbation, and homomorphic encryption are inapplicable to online prompt-based LLM applications. To address these issues, this paper introduces Prompt Privacy Sanitizer (i.e., ProSan), an end-to-end prompt privacy protection framework that can produce anonymized prompts with contextual privacy removed while maintaining task usability and human readability. It can also be seamlessly integrated into the online LLM service pipeline. To achieve high usability and dynamic anonymity, ProSan flexibly adjusts its protection targets and strength based on the importance of the words and the privacy leakage risk of the prompts. Additionally, ProSan is capable of adapting to diverse computational resource conditions, ensuring privacy protection even for mobile devices with limited computing power. Our experiments demonstrate that ProSan effectively removes private information across various tasks, including question answering, text summarization, and code generation, with minimal reduction in task performance.

Diagnostic Captioning (DC) automatically generates a diagnostic text from one or more medical images (e.g., X-rays, MRIs) of a patient. Treated as a draft, the generated text may assist clinicians, by providing an initial estimation of the patient's condition, speeding up and helping safeguard the diagnostic process. The accuracy of a diagnostic text, however, strongly depends on how well the key medical conditions depicted in the images are expressed. We propose a new data-driven guided decoding method that incorporates medical information, in the form of existing tags capturing key conditions of the image(s), into the beam search of the diagnostic text generation process. We evaluate the proposed method on two medical datasets using four DC systems that range from generic image-to-text systems with CNN encoders and RNN decoders to pre-trained Large Language Models. The latter can also be used in few- and zero-shot learning scenarios. In most cases, the proposed mechanism improves performance with respect to all evaluation measures. We provide an open-source implementation of the proposed method at https://github.com/nlpaueb/dmmcs.

Language models (LMs) estimate the probability distribution over sequences of natural language; these distributions are crucial for computing perplexity and surprisal in linguistics research. While we are usually concerned with measuring these values for words, most LMs operate over subwords. Despite seemingly straightforward, accurately computing probabilities over one unit given probabilities over the other requires care. Indeed, we show here that many recent linguistic studies have been incorrectly computing these values. This paper derives the correct methods for computing word probabilities, highlighting issues when relying on language models that use beginning-of-word (bow)-marking tokenisers, e.g., the GPT family. Empirically, we show that correcting the widespread bug in probability computations affects measured outcomes in sentence comprehension and lexical optimisation analyses.

While the situation has improved for text-only models, it again seems to be the case currently that multimodal (text and image) models develop faster than ways to evaluate them. In this paper, we bring a recently developed evaluation paradigm from text models to multimodal models, namely evaluation through the goal-oriented game (self) play, complementing reference-based and preference-based evaluation. Specifically, we define games that challenge a model's capability to represent a situation from visual information and align such representations through dialogue. We find that the largest closed models perform rather well on the games that we define, while even the best open-weight models struggle with them. On further analysis, we find that the exceptional deep captioning capabilities of the largest models drive some of the performance. There is still room to grow for both kinds of models, ensuring the continued relevance of the benchmark.

Data contamination has garnered increased attention in the era of large language models (LLMs) due to the reliance on extensive internet-derived training corpora. The issue of training corpus overlap with evaluation benchmarks--referred to as contamination--has been the focus of significant recent research. This body of work aims to identify contamination, understand its impacts, and explore mitigation strategies from diverse perspectives. However, comprehensive studies that provide a clear pathway from foundational concepts to advanced insights are lacking in this nascent field. Therefore, we present a comprehensive survey in the field of data contamination, laying out the key issues, methodologies, and findings to date, and highlighting areas in need of further research and development. In particular, we begin by examining the effects of data contamination across various stages and forms. We then provide a detailed analysis of current contamination detection methods, categorizing them to highlight their focus, assumptions, strengths, and limitations. We also discuss mitigation strategies, offering a clear guide for future research. This survey serves as a succinct overview of the most recent advancements in data contamination research, providing a straightforward guide for the benefit of future research endeavors.

Biological sequences encode fundamental instructions for the building blocks of life, in the form of DNA, RNA, and proteins. Modeling these sequences is key to understand disease mechanisms and is an active research area in computational biology. Recently, Large Language Models have shown great promise in solving certain biological tasks but current approaches are limited to a single sequence modality (DNA, RNA, or protein). Key problems in genomics intrinsically involve multiple modalities, but it remains unclear how to adapt general-purpose sequence models to those cases. In this work we propose a multi-modal model that connects DNA, RNA, and proteins by leveraging information from different pre-trained modality-specific encoders. We demonstrate its capabilities by applying it to the largely unsolved problem of predicting how multiple RNA transcript isoforms originate from the same gene (i.e. same DNA sequence) and map to different transcription expression levels across various human tissues. We show that our model, dubbed IsoFormer, is able to accurately predict differential transcript expression, outperforming existing methods and leveraging the use of multiple modalities. Our framework also achieves efficient transfer knowledge from the encoders pre-training as well as in between modalities. We open-source our model, paving the way for new multi-modal gene expression approaches.