Reinforcement Learning (RL) has been used to finetune Large Language Models (LLMs) using a reward model trained from preference data, to better align with human judgment. The recently introduced direct alignment methods, which are often simpler, more stable, and computationally lighter, can more directly achieve this. However, these approaches cannot optimize arbitrary rewards, and the preference-based ones are not the only rewards of interest for LLMs (eg., unit tests for code generation or textual entailment for summarization, among others). RL-finetuning is usually done with a variation of policy gradient, which calls for on-policy or near-on-policy samples, requiring costly generations. We introduce Contrastive Policy Gradient, or CoPG, a simple and mathematically principled new RL algorithm that can estimate the optimal policy even from off-policy data. It can be seen as an off-policy policy gradient approach that does not rely on important sampling techniques and highlights the importance of using (the right) state baseline. We show this approach to generalize the direct alignment method IPO (identity preference optimization) and classic policy gradient. We experiment with the proposed CoPG on a toy bandit problem to illustrate its properties, as well as for finetuning LLMs on a summarization task, using a learned reward function considered as ground truth for the purpose of the experiments.

Large language models (LLMs) have shown exceptional performance across various text generation tasks but remain under-explored in the patent domain, which offers highly structured and precise language. This paper constructs a dataset to investigate the performance of current LLMs in patent claim generation. Our results demonstrate that generating claims based on patent descriptions outperforms previous research relying on abstracts. Interestingly, current patent-specific LLMs perform much worse than state-of-the-art general LLMs, highlighting the necessity for future research on in-domain LLMs. We also find that LLMs can produce high-quality first independent claims, but their performances markedly decrease for subsequent dependent claims. Moreover, fine-tuning can enhance the completeness of inventions' features, conceptual clarity, and feature linkage. Among the tested LLMs, GPT-4 demonstrates the best performance in comprehensive human evaluations by patent experts, with better feature coverage, conceptual clarity, and technical coherence. Despite these capabilities, comprehensive revision and modification are still necessary to pass rigorous patent scrutiny and ensure legal robustness.

Combining Large Language Models (LLMs) with search engine services marks a significant shift in the field of services computing, opening up new possibilities to enhance how we search for and retrieve information, understand content, and interact with internet services. This paper conducts an in-depth examination of how integrating LLMs with search engines can mutually benefit both technologies. We focus on two main areas: using search engines to improve LLMs (Search4LLM) and enhancing search engine functions using LLMs (LLM4Search). For Search4LLM, we investigate how search engines can provide diverse high-quality datasets for pre-training of LLMs, how they can use the most relevant documents to help LLMs learn to answer queries more accurately, how training LLMs with Learning-To-Rank (LTR) tasks can enhance their ability to respond with greater precision, and how incorporating recent search results can make LLM-generated content more accurate and current. In terms of LLM4Search, we examine how LLMs can be used to summarize content for better indexing by search engines, improve query outcomes through optimization, enhance the ranking of search results by analyzing document relevance, and help in annotating data for learning-to-rank tasks in various learning contexts. However, this promising integration comes with its challenges, which include addressing potential biases and ethical issues in training models, managing the computational and other costs of incorporating LLMs into search services, and continuously updating LLM training with the ever-changing web content. We discuss these challenges and chart out required research directions to address them. We also discuss broader implications for service computing, such as scalability, privacy concerns, and the need to adapt search engine architectures for these advanced models.

Microscopic interpretation of histopathology images underlies many important diagnostic and treatment decisions. While advances in vision-language modeling raise new opportunities for analysis of such images, the gigapixel-scale size of whole slide images (WSIs) introduces unique challenges. Additionally, pathology reports simultaneously highlight key findings from small regions while also aggregating interpretation across multiple slides, often making it difficult to create robust image-text pairs. As such, pathology reports remain a largely untapped source of supervision in computational pathology, with most efforts relying on region-of-interest annotations or self-supervision at the patch-level. In this work, we develop a vision-language model based on the BLIP-2 framework using WSIs paired with curated text from pathology reports. This enables applications utilizing a shared image-text embedding space, such as text or image retrieval for finding cases of interest, as well as integration of the WSI encoder with a frozen large language model (LLM) for WSI-based generative text capabilities such as report generation or AI-in-the-loop interactions. We utilize a de-identified dataset of over 350,000 WSIs and diagnostic text pairs, spanning a wide range of diagnoses, procedure types, and tissue types. We present pathologist evaluation of text generation and text retrieval using WSI embeddings, as well as results for WSI classification and workflow prioritization (slide-level triaging). Model-generated text for WSIs was rated by pathologists as accurate, without clinically significant error or omission, for 78% of WSIs on average. This work demonstrates exciting potential capabilities for language-aligned WSI embeddings.

Existing research on instruction following largely focuses on tasks with simple instructions and short responses. In this work, we explore multi-constraint instruction following for generating long-form text. We create Suri, a dataset with 20K human-written long-form texts paired with LLM-generated backtranslated instructions that contain multiple complex constraints. Because of prohibitive challenges associated with collecting human preference judgments on long-form texts, preference-tuning algorithms such as DPO are infeasible in our setting; thus, we propose Instructional ORPO (I-ORPO), an alignment method based on the ORPO algorithm. Instead of receiving negative feedback from dispreferred responses, I-ORPO obtains negative feedback from synthetically corrupted instructions generated by an LLM. Using Suri, we perform supervised and I-ORPO fine-tuning on Mistral-7b-Instruct-v0.2. The resulting models, Suri-SFT and Suri-I-ORPO, generate significantly longer texts (~5K tokens) than base models without significant quality deterioration. Our human evaluation shows that while both SFT and I-ORPO models satisfy most constraints, Suri-I-ORPO generations are generally preferred for their coherent and informative incorporation of the constraints. We release our code at https://github.com/chtmp223/suri.

We aim to understand the extent to more on generic pretrained representation, or develop which fine-tuned models depend on their pretrained representations brand new task-specific solutions? Here, to solve a novel task. To this end, we compare the we fine-tuned GPT-2 on a context-dependent representations after fine-tuning with those developed by decision-making task, novel to the model but GPT-2 optimized solely on this task from scratch. We chose adapted from neuroscience literature. We compared this task not only because it is novel but also because its its performance and internal mechanisms grounding in neuroscience allows us to explore the data with to a version of GPT-2 trained from scratch on computational neuroscience methods and make direct comparisons the same task. Our results show that fine-tuned between representations in biological and artificial models depend heavily on pretrained representations, neural networks.

The emergence of in-context learning (ICL) enables large pre-trained language models (PLMs) to make predictions for unseen inputs without updating parameters. Despite its potential, ICL's effectiveness heavily relies on the quality, quantity, and permutation of demonstrations, commonly leading to suboptimal and unstable performance. In this paper, we tackle this challenge for the first time from the perspective of demonstration augmentation. Specifically, we start with enriching representations of demonstrations by leveraging their deep feature distribution. We then theoretically reveal that when the number of augmented copies approaches infinity, the augmentation is approximately equal to a novel logit calibration mechanism integrated with specific statistical properties. This insight results in a simple yet highly efficient method that significantly improves the average and worst-case accuracy across diverse PLMs and tasks. Moreover, our method effectively reduces performance variance among varying demonstrations, permutations, and templates, and displays the capability to address imbalanced class distributions.

The rapid development of multimodal large language models (MLLMs), such as GPT-4V, has led to significant advancements. However, these models still face challenges in medical multimodal capabilities due to limitations in the quantity and quality of medical vision-text data, stemming from data privacy concerns and high annotation costs. While pioneering approaches utilize PubMed's large-scale, de-identified medical image-text pairs to address these limitations, they still fall short due to inherent data noise. To tackle this, we refined medical image-text pairs from PubMed and employed MLLMs (GPT-4V) in an 'unblinded' capacity to denoise and reformat the data, resulting in the creation of the PubMedVision dataset with 1.3 million medical VQA samples. Our validation demonstrates that: (1) PubMedVision can significantly enhance the medical multimodal capabilities of current MLLMs, showing significant improvement in benchmarks including the MMMU Health & Medicine track; (2) manual checks by medical experts and empirical results validate the superior data quality of our dataset compared to other data construction methods. Using PubMedVision, we train a 34B medical MLLM HuatuoGPT-Vision, which shows superior performance in medical multimodal scenarios among open-source MLLMs.

To better align Large Language Models (LLMs) with human judgment, Reinforcement Learning from Human Feedback (RLHF) learns a reward model and then optimizes it using regularized RL. Recently, direct alignment methods were introduced to learn such a fine-tuned model directly from a preference dataset without computing a proxy reward function. These methods are built upon contrastive losses involving the log-likelihood of (dis)preferred completions according to the trained model. However, completions have various lengths, and the log-likelihood is not length-invariant. On the other side, the cross-entropy loss used in supervised training is length-invariant, as batches are typically averaged token-wise. To reconcile these approaches, we introduce a principled approach for making direct alignment length-invariant. Formally, we introduce a new averaging operator, to be composed with the optimality operator giving the best policy for the underlying RL problem. It translates into averaging the log-likelihood within the loss. We empirically study the effect of such averaging, observing a trade-off between the length of generations and their scores.

The integration of Generative Artificial Intelligence (GAI) and Large Language Models (LLMs) in academia has spurred a global discourse on their potential pedagogical benefits and ethical considerations. Positive reactions highlight some potential, such as collaborative creativity, increased access to education, and empowerment of trainers and trainees. However, negative reactions raise concerns about ethical complexities, balancing innovation and academic integrity, unequal access, and misinformation risks. Through a systematic survey and text-mining-based analysis of global and national directives, insights from independent research, and eighty university-level guidelines, this study provides a nuanced understanding of the opportunities and challenges posed by GAI and LLMs in education. It emphasizes the importance of balanced approaches that harness the benefits of these technologies while addressing ethical considerations and ensuring equitable access and educational outcomes. The paper concludes with recommendations for fostering responsible innovation and ethical practices to guide the integration of GAI and LLMs in academia.