Large language models (LLMs) have demonstrated potential applications in medicine, yet data privacy and computational burden limit their deployment in healthcare institutions. Open-source and lightweight versions of LLMs emerge as potential solutions, but their performance, particularly in pediatric settings remains underexplored. In this cross-sectional study, 250 patient consultation questions were randomly selected from a public online medical forum, with 10 questions from each of 25 pediatric departments, spanning from December 1, 2022, to October 30, 2023. Two lightweight open-source LLMs, ChatGLM3-6B and Vicuna-7B, along with a larger-scale model, Vicuna-13B, and the widely-used proprietary ChatGPT-3.5, independently answered these questions in Chinese between November 1, 2023, and November 7, 2023. To assess reproducibility, each inquiry was replicated once. We found that ChatGLM3-6B demonstrated higher accuracy and completeness than Vicuna-13B and Vicuna-7B (P < .001), but all were outperformed by ChatGPT-3.5. ChatGPT-3.5 received the highest ratings in accuracy (65.2%) compared to ChatGLM3-6B (41.2%), Vicuna-13B (11.2%), and Vicuna-7B (4.4%). Similarly, in completeness, ChatGPT-3.5 led (78.4%), followed by ChatGLM3-6B (76.0%), Vicuna-13B (34.8%), and Vicuna-7B (22.0%) in highest ratings. ChatGLM3-6B matched ChatGPT-3.5 in readability, both outperforming Vicuna models (P < .001). In terms of empathy, ChatGPT-3.5 outperformed the lightweight LLMs (P < .001). In safety, all models performed comparably well (P > .05), with over 98.4% of responses being rated as safe. Repetition of inquiries confirmed these findings. In conclusion, Lightweight LLMs demonstrate promising application in pediatric healthcare. However, the observed gap between lightweight and large-scale proprietary LLMs underscores the need for continued development efforts.

Binding affinity optimization is crucial in early-stage drug discovery. While numerous machine learning methods exist for predicting ligand potency, their comparative efficacy remains unclear. This study evaluates the performance of classical tree-based models and advanced neural networks in protein-ligand binding affinity prediction. Our comprehensive benchmarking encompasses 2D models utilizing ligand-only RDKit embeddings and Large Language Model (LLM) ligand representations, as well as 3D neural networks incorporating bound protein-ligand conformations. We assess these models across multiple standard datasets, examining various predictive scenarios including classification, ranking, regression, and active learning. Results indicate that simpler models can surpass more complex ones in specific tasks, while 3D models leveraging structural information become increasingly competitive with larger training datasets containing compounds with labelled affinity data against multiple targets. Pre-trained 3D models, by incorporating protein pocket environments, demonstrate significant advantages in data-scarce scenarios for specific binding pockets. Additionally, LLM pretraining on 2D ligand data enhances complex model performance, providing versatile embeddings that outperform traditional RDKit features in computational efficiency. Finally, we show that combining 2D and 3D model strengths improves active learning outcomes beyond current state-of-the-art approaches. These findings offer valuable insights for optimizing machine learning strategies in drug discovery pipelines.

Large language models (LLMs) can exhibit bias in a variety of ways. Such biases can create or exacerbate unfair outcomes for certain groups within a protected attribute, including, but not limited to sex, race, sexual orientation, or age. This paper aims to provide a technical guide for practitioners to assess bias and fairness risks in LLM use cases. The main contribution of this work is a decision framework that allows practitioners to determine which metrics to use for a specific LLM use case. To achieve this, this study categorizes LLM bias and fairness risks, maps those risks to a taxonomy of LLM use cases, and then formally defines various metrics to assess each type of risk. As part of this work, several new bias and fairness metrics are introduced, including innovative counterfactual metrics as well as metrics based on stereotype classifiers. Instead of focusing solely on the model itself, the sensitivity of both prompt-risk and model-risk are taken into account by defining evaluations at the level of an LLM use case, characterized by a model and a population of prompts. Furthermore, because all of the evaluation metrics are calculated solely using the LLM output, the proposed framework is highly practical and easily actionable for practitioners.

We introduce the latest progress of Qwen-Audio, a large-scale audio-language model called Qwen2-Audio, which is capable of accepting various audio signal inputs and performing audio analysis or direct textual responses with regard to speech instructions. In contrast to complex hierarchical tags, we have simplified the pre-training process by utilizing natural language prompts for different data and tasks, and have further expanded the data volume. We have boosted the instruction-following capability of Qwen2-Audio and implemented two distinct audio interaction modes for voice chat and audio analysis. In the voice chat mode, users can freely engage in voice interactions with Qwen2-Audio without text input. In the audio analysis mode, users could provide audio and text instructions for analysis during the interaction. Note that we do not use any system prompts to switch between voice chat and audio analysis modes. Qwen2-Audio is capable of intelligently comprehending the content within audio and following voice commands to respond appropriately. For instance, in an audio segment that simultaneously contains sounds, multi-speaker conversations, and a voice command, Qwen2-Audio can directly understand the command and provide an interpretation and response to the audio. Additionally, DPO has optimized the model's performance in terms of factuality and adherence to desired behavior. According to the evaluation results from AIR-Bench, Qwen2-Audio outperformed previous SOTAs, such as Gemini-1.5-pro, in tests focused on audio-centric instruction-following capabilities. Qwen2-Audio is open-sourced with the aim of fostering the advancement of the multi-modal language community.

Vision-language models have been extensively explored across a wide range of tasks, achieving satisfactory performance; however, their application in medical imaging remains underexplored. In this work, we propose a unified framework - LiteGPT - for the medical imaging. We leverage multiple pre-trained visual encoders to enrich information and enhance the performance of vision-language models. To the best of our knowledge, this is the first study to utilize vision-language models for the novel task of joint localization and classification in medical images. Besides, we are pioneers in providing baselines for disease localization in chest X-rays. Finally, we set new state-of-the-art performance in the image classification task on the well-benchmarked VinDr-CXR dataset. All code and models are publicly available online: https://github.com/leduckhai/LiteGPT

Assessing the effectiveness of large language models (LLMs) presents substantial challenges. The method of conducting human-annotated battles in an online Chatbot Arena is a highly effective evaluative technique. However, this approach is limited by the costs and time required for human annotation. In this paper, we introduce Arena Learning, an innovative offline strategy designed to simulate these arena battles using AI-driven annotations to evaluate battle outcomes, thus facilitating the continuous improvement of the target model through both supervised fine-tuning and reinforcement learning. Arena Learning comprises two key elements. First, it ensures precise evaluations and maintains consistency between offline simulations and online competitions via WizardArena, a pipeline developed to accurately predict the Elo rankings of various models using a meticulously designed offline test set. Our results demonstrate that WizardArena's predictions closely align with those from the online Arena. Second, it involves the continuous improvement of training data based on the battle results and the refined model. We establish a data flywheel to iteratively update the training data by highlighting the weaknesses of the target model based on its battle results, enabling it to learn from the strengths of multiple different models. We apply Arena Learning to train our target model, WizardLM-$\beta$, and demonstrate significant performance enhancements across various metrics. This fully automated training and evaluation pipeline sets the stage for continuous advancements in various LLMs via post-training. Notably, Arena Learning plays a pivotal role in the success of WizardLM-2, and this paper serves both as an exploration of its efficacy and a foundational study for future discussions related to WizardLM-2 and its derivatives.

We introduce, Q-Sparse, a simple yet effective approach to training sparsely-activated large language models (LLMs). Q-Sparse enables full sparsity of activations in LLMs which can bring significant efficiency gains in inference. This is achieved by applying top-K sparsification to the activations and the straight-through-estimator to the training. The key results from this work are, (1) Q-Sparse can achieve results comparable to those of baseline LLMs while being much more efficient at inference time; (2) We present an inference-optimal scaling law for sparsely-activated LLMs; (3) Q-Sparse is effective in different settings, including training-from-scratch, continue-training of off-the-shelf LLMs, and finetuning; (4) Q-Sparse works for both full-precision and 1-bit LLMs (e.g., BitNet b1.58). Particularly, the synergy of BitNet b1.58 and Q-Sparse (can be equipped with MoE) provides the cornerstone and a clear path to revolutionize the efficiency, including cost and energy consumption, of future LLMs.

Hybrid intelligence aims to enhance decision-making, problem-solving, and overall system performance by combining the strengths of both, human cognitive abilities and artificial intelligence. With the rise of Large Language Models (LLM), progressively participating as smart agents to accelerate machine learning development, Hybrid Intelligence is becoming an increasingly important topic for effective interaction between humans and machines. This paper presents an approach to leverage Hybrid Intelligence towards sustainable and energy-aware machine learning. When developing machine learning models, final model performance commonly rules the optimization process while the efficiency of the process itself is often neglected. Moreover, in recent times, energy efficiency has become equally crucial due to the significant environmental impact of complex and large-scale computational processes. The contribution of this work covers the interactive inclusion of secondary knowledge sources through Human-in-the-loop (HITL) and LLM agents to stress out and further resolve inefficiencies in the machine learning development process.

The Mutual Reinforcement Effect (MRE) represents a promising avenue in information extraction and multitasking research. Nevertheless, its applicability has been constrained due to the exclusive availability of MRE mix datasets in Japanese, thereby limiting comprehensive exploration by the global research community. To address this limitation, we introduce a Multilingual MRE mix dataset (MMM) that encompasses 21 sub-datasets in English, Japanese, and Chinese. In this paper, we also propose a method for dataset translation assisted by Large Language Models (LLMs), which significantly reduces the manual annotation time required for dataset construction by leveraging LLMs to translate the original Japanese datasets. Additionally, we have enriched the dataset by incorporating open-domain Named Entity Recognition (NER) and sentence classification tasks. Utilizing this expanded dataset, we developed a unified input-output framework to train an Open-domain Information Extraction Large Language Model (OIELLM). The OIELLM model demonstrates the capability to effectively process novel MMM datasets, exhibiting significant improvements in performance.

Effective educational measurement relies heavily on the curation of well-designed item pools (i.e., possessing the right psychometric properties). However, item calibration is time-consuming and costly, requiring a sufficient number of respondents for the response process. We explore using six different LLMs (GPT-3.5, GPT-4, Llama 2, Llama 3, Gemini-Pro, and Cohere Command R Plus) and various combinations of them using sampling methods to produce responses with psychometric properties similar to human answers. Results show that some LLMs have comparable or higher proficiency in College Algebra than college students. No single LLM mimics human respondents due to narrow proficiency distributions, but an ensemble of LLMs can better resemble college students' ability distribution. The item parameters calibrated by LLM-Respondents have high correlations (e.g. > 0.8 for GPT-3.5) compared to their human calibrated counterparts, and closely resemble the parameters of the human subset (e.g. 0.02 Spearman correlation difference). Several augmentation strategies are evaluated for their relative performance, with resampling methods proving most effective, enhancing the Spearman correlation from 0.89 (human only) to 0.93 (augmented human).