The vast amount of biomedical information available today presents a significant challenge for investigators seeking to digest, process, and understand these findings effectively. Large Language Models (LLMs) have emerged as powerful tools to navigate this complex and challenging data landscape. However, LLMs may lead to hallucinatory responses, making Retrieval Augmented Generation (RAG) crucial for achieving accurate information. In this protocol, we present RUGGED (Retrieval Under Graph-Guided Explainable disease Distinction), a comprehensive workflow designed to support investigators with knowledge integration and hypothesis generation, identifying validated paths forward. Relevant biomedical information from publications and knowledge bases are reviewed, integrated, and extracted via text-mining association analysis and explainable graph prediction models on disease nodes, forecasting potential links among drugs and diseases. These analyses, along with biomedical texts, are integrated into a framework that facilitates user-directed mechanism elucidation as well as hypothesis exploration through RAG-enabled LLMs. A clinical use-case demonstrates RUGGED's ability to evaluate and recommend therapeutics for Arrhythmogenic Cardiomyopathy (ACM) and Dilated Cardiomyopathy (DCM), analyzing prescribed drugs for molecular interactions and unexplored uses. The platform minimizes LLM hallucinations, offers actionable insights, and improves the investigation of novel therapeutics.

In this paper, we investigate the underlying factors that potentially enhance the mathematical reasoning capabilities of large language models (LLMs). We argue that the data scaling law for math reasoning capabilities in modern LLMs is far from being saturated, highlighting how the model's quality improves with increases in data quantity. To support this claim, we introduce the Skywork-Math model series, supervised fine-tuned (SFT) on common 7B LLMs using our proposed 2.5M-instance Skywork-MathQA dataset. Skywork-Math 7B has achieved impressive accuracies of 51.2% on the competition-level MATH benchmark and 83.9% on the GSM8K benchmark using only SFT data, outperforming an early version of GPT-4 on MATH. The superior performance of Skywork-Math models contributes to our novel two-stage data synthesis and model SFT pipelines, which include three different augmentation methods and a diverse seed problem set, ensuring both the quantity and quality of Skywork-MathQA dataset across varying difficulty levels. Most importantly, we provide several practical takeaways to enhance math reasoning abilities in LLMs for both research and industry applications.

Multi-hop question answering is a challenging task with distinct industrial relevance, and Retrieval-Augmented Generation (RAG) methods based on large language models (LLMs) have become a popular approach to tackle this task. Owing to the potential inability to retrieve all necessary information in a single iteration, a series of iterative RAG methods has been recently developed, showing significant performance improvements. However, existing methods still face two critical challenges: context overload resulting from multiple rounds of retrieval, and over-planning and repetitive planning due to the lack of a recorded retrieval trajectory. In this paper, we propose a novel iterative RAG method called ReSP, equipped with a dual-function summarizer. This summarizer compresses information from retrieved documents, targeting both the overarching question and the current sub-question concurrently. Experimental results on the multi-hop question-answering datasets HotpotQA and 2WikiMultihopQA demonstrate that our method significantly outperforms the state-of-the-art, and exhibits excellent robustness concerning context length.

Instruction-tuned large language models, such as T0, have demonstrated remarkable capabilities in following instructions across various domains. However, their proficiency remains notably deficient in many low-resource languages. To address this challenge, we introduce FarsInstruct: a comprehensive instruction dataset designed to enhance the instruction-following ability of large language models specifically for the Persian language, a significant yet underrepresented language globally. FarsInstruct encompasses a wide range of task types and datasets, each containing a mix of straightforward to complex manual written instructions, as well as translations from Public Pool of Prompts, ensuring a rich linguistic and cultural representation. Furthermore, we introduce Co-CoLA, a framework designed to enhance the multi-task adaptability of LoRA-tuned models. Through extensive experimental analyses, our study showcases the effectiveness of FarsInstruct dataset coupled with training by Co-CoLA framework, in improving the performance of large language models within the Persian context. As of the current writing, FarsInstruct comprises more than 200 templates across 21 distinct datasets, and we intend to update it consistently, thus augmenting its applicability.

Multimodal large language models (MLLMs) have shown promising advancements in general visual and language understanding. However, the representation of multimodal information using MLLMs remains largely unexplored. In this work, we introduce a new framework, E5-V, designed to adapt MLLMs for achieving universal multimodal embeddings. Our findings highlight the significant potential of MLLMs in representing multimodal inputs compared to previous approaches. By leveraging MLLMs with prompts, E5-V effectively bridges the modality gap between different types of inputs, demonstrating strong performance in multimodal embeddings even without fine-tuning. We propose a single modality training approach for E5-V, where the model is trained exclusively on text pairs. This method demonstrates significant improvements over traditional multimodal training on image-text pairs, while reducing training costs by approximately 95%. Additionally, this approach eliminates the need for costly multimodal training data collection. Extensive experiments across four types of tasks demonstrate the effectiveness of E5-V. As a universal multimodal model, E5-V not only achieves but often surpasses state-of-the-art performance in each task, despite being trained on a single modality.

A globally distributed IC supply chain brings risks due to untrusted third parties. The risks span inadvertent use of hardware Trojan (HT), inserted Intellectual Property (3P-IP) or Electronic Design Automation (EDA) flows. HT can introduce stealthy HT behavior, prevent an IC work as intended, or leak sensitive data via side channels. To counter HTs, rapidly examining HT scenarios is a key requirement. While Trust-Hub benchmarks are a good starting point to assess defenses, they encompass a small subset of manually created HTs within the expanse of HT designs. Further, the HTs may disappear during synthesis. We propose a large language model (LLM) framework SENTAUR to generate a suite of legitimate HTs for a Register Transfer Level (RTL) design by learning its specifications, descriptions, and natural language descriptions of HT effects. Existing tools and benchmarks are limited; they need a learning period to construct an ML model to mimic the threat model and are difficult to reproduce. SENTAUR can swiftly produce HT instances by leveraging LLMs without any learning period and sanitizing the HTs facilitating their rapid assessment. Evaluation of SENTAUR involved generating effective, synthesizable, and practical HTs from TrustHub and elsewhere, investigating impacts of payloads/triggers at the RTL. While our evaluation focused on HT insertion, SENTAUR can generalize to automatically transform an RTL code to have defined functional modifications.

In this work we proposing adapting the Minecraft builder task into an LLM benchmark suitable for evaluating LLM ability in spatially orientated tasks, and informing builder agent design. Previous works have proposed corpora with varying complex structures, and human written instructions. We instead attempt to provide a comprehensive synthetic benchmark for testing builder agents over a series of distinct tasks that comprise of common building operations. We believe this approach allows us to probe specific strengths and weaknesses of different agents, and test the ability of LLMs in the challenging area of spatial reasoning and vector based math.

Complex reasoning is an impressive ability shown by large language models (LLMs). Most LLMs are skilled in deductive reasoning, such as chain-of-thought prompting or iterative tool-using to solve challenging tasks step-by-step. In this paper, we hope to focus on evaluating and teaching LLMs to conduct inductive reasoning, that is, LLMs are supposed to infer underlying rules by observing examples or sequential transformations. However, collecting large-scale and diverse human-generated inductive data is challenging. We focus on data synthesis in the code domain and propose a \textbf{Case2Code} task by exploiting the expressiveness and correctness of programs. Specifically, we collect a diverse set of executable programs, synthesize input-output transformations for each program, and force LLMs to infer the underlying code implementations based on the synthetic I/O cases. We first evaluate representative LLMs on the synthesized Case2Code task and demonstrate that the Case-to-code induction is challenging for LLMs. Then, we synthesize large-scale Case2Code training samples to train LLMs to perform inductive reasoning. Experimental results show that such induction training benefits not only in distribution Case2Code performance but also enhances various coding abilities of trained LLMs, demonstrating the great potential of learning inductive reasoning via synthetic data.

The rapid expansion of multimedia content has made accurately retrieving relevant videos from large collections increasingly challenging. Recent advancements in text-video retrieval have focused on cross-modal interactions, large-scale foundation model training, and probabilistic modeling, yet often neglect the crucial user perspective, leading to discrepancies between user queries and the content retrieved. To address this, we introduce MERLIN (Multimodal Embedding Refinement via LLM-based Iterative Navigation), a novel, training-free pipeline that leverages Large Language Models (LLMs) for iterative feedback learning. MERLIN refines query embeddings from a user perspective, enhancing alignment between queries and video content through a dynamic question answering process. Experimental results on datasets like MSR-VTT, MSVD, and ActivityNet demonstrate that MERLIN substantially improves Recall@1, outperforming existing systems and confirming the benefits of integrating LLMs into multimodal retrieval systems for more responsive and context-aware multimedia retrieval.

In spite of recent advancements in text-to-image generation, limitations persist in handling complex and imaginative prompts due to the restricted diversity and complexity of training data. This work explores how diffusion models can generate images from prompts requiring artistic creativity or specialized knowledge. We introduce the Realistic-Fantasy Benchmark (RFBench), a novel evaluation framework blending realistic and fantastical scenarios. To address these challenges, we propose the Realistic-Fantasy Network (RFNet), a training-free approach integrating diffusion models with LLMs. Extensive human evaluations and GPT-based compositional assessments demonstrate our approach's superiority over state-of-the-art methods.