Systematic reviews (SRs) are essential for evidence-based guidelines but are often limited by the time-consuming nature of literature screening. We propose and evaluate an in-house system based on Large Language Models (LLMs) for automating both title/abstract and full-text screening, addressing a critical gap in the literature. Using a completed SR on Vitamin D and falls (14,439 articles), the LLM-based system employed prompt engineering for title/abstract screening and Retrieval-Augmented Generation (RAG) for full-text screening. The system achieved an article exclusion rate (AER) of 99.5%, specificity of 99.6%, a false negative rate (FNR) of 0%, and a negative predictive value (NPV) of 100%. After screening, only 78 articles required manual review, including all 20 identified by traditional methods, reducing manual screening time by 95.5%. For comparison, Rayyan, a commercial tool for title/abstract screening, achieved an AER of 72.1% and FNR of 5% when including articles Rayyan considered as undecided or likely to include. Lowering Rayyan's inclusion thresholds improved FNR to 0% but increased screening time. By addressing both screening phases, the LLM-based system significantly outperformed Rayyan and traditional methods, reducing total screening time to 25.5 hours while maintaining high accuracy. These findings highlight the transformative potential of LLMs in SR workflows by offering a scalable, efficient, and accurate solution, particularly for the full-text screening phase, which has lacked automation tools.

The Controllable Image Captioning Agent (CapAgent) is an innovative system designed to bridge the gap between user simplicity and professional-level outputs in image captioning tasks. CapAgent automatically transforms user-provided simple instructions into detailed, professional instructions, enabling precise and context-aware caption generation. By leveraging multimodal large language models (MLLMs) and external tools such as object detection tool and search engines, the system ensures that captions adhere to specified guidelines, including sentiment, keywords, focus, and formatting. CapAgent transparently controls each step of the captioning process, and showcases its reasoning and tool usage at every step, fostering user trust and engagement.

The field of autonomous web navigation has seen significant advancements, driven by the capabilities of Large Language Models (LLMs) in both mobile and webpage interactions [Wang et al., 2024a, Mialon et al., 2023, Xi et al., 2023]. Preliminary attempts, such as the ChatGPT Plugin [OpenAI, 2023], have also started building practical applications of web knowledge-based chatbot. Web navigation can be described as processes where agents perform specific tasks on behalf of human users within a web environment, involving the interpretation of high-level user instructions, decomposing them into basic operations, and interacting with complex web pages dynamically. To achieve this, agents must understand intricate web scenarios, adapt to dynamic changes such as noisy text and evolving HTML structures, and generalize successful operations to unseen tasks, thus freeing humans from repetitive interactions with computer interfaces. Traditional web agents trained through reinforcement learning [Shi et al., 2017, Yao et al., 2022] often mimic human behavior using predefined actions like typing, searching, and navigating to a specific page.

Current language models (LMs) use a fixed, static subword tokenizer. This default choice typically results in degraded efficiency and language capabilities, especially in languages other than English. To address this issue, we challenge the static design and propose retrofitting LMs with dynamic tokenization: a way to dynamically decide on token boundaries based on the input text via a subword-merging algorithm inspired by byte-pair encoding. We merge frequent subword sequences in a batch, then apply a pre-trained embedding-prediction hypernetwork to compute the token embeddings on-the-fly. For encoder-style models (e.g., XLM-R), this on average reduces token sequence lengths by >20% across 14 languages while degrading performance by less than 2%. The same method applied to pre-filling and scoring in decoder-style models (e.g., Mistral-7B; evaluated on English) results in minimal performance degradation at up to 6% reduction in sequence length. Overall, we find that dynamic tokenization can mitigate the limitations of static tokenization by substantially improving inference speed and promoting fairness across languages, enabling more equitable and adaptable LMs.

Foresight 2 (FS2) is a large language model fine-tuned on hospital data for modelling patient timelines (GitHub 'removed for anon'). It can understand patients' clinical notes and predict SNOMED codes for a wide range of biomedical use cases, including diagnosis suggestions, risk forecasting, and procedure and medication recommendations. FS2 is trained on the free text portion of the MIMIC-III dataset, firstly through extracting biomedical concepts and then creating contextualised patient timelines, upon which the model is then fine-tuned. The results show significant improvement over the previous state-of-the-art for the next new biomedical concept prediction (P/R - 0.73/0.66 vs 0.52/0.32) and a similar improvement specifically for the next new disorder prediction (P/R - 0.69/0.62 vs 0.46/0.25). Finally, on the task of risk forecast, we compare our model to GPT-4-turbo (and a range of open-source biomedical LLMs) and show that FS2 performs significantly better on such tasks (P@5 - 0.90 vs 0.65). This highlights the need to incorporate hospital data into LLMs and shows that small models outperform much larger ones when fine-tuned on high-quality, specialised data.

Performance of large language models (LLMs) on medical tasks has traditionally been evaluated using multiple choice question benchmarks. However, such benchmarks are highly constrained, saturated with repeated impressive performance by LLMs, and have an unclear relationship to performance in real clinical scenarios. Clinical reasoning, the process by which physicians employ critical thinking to gather and synthesize clinical data to diagnose and manage medical problems, remains an attractive benchmark for model performance. Prior LLMs have shown promise in outperforming clinicians in routine and complex diagnostic scenarios. We sought to evaluate OpenAI's o1-preview model, a model developed to increase run-time via chain of thought processes prior to generating a response. We characterize the performance of o1-preview with five experiments including differential diagnosis generation, display of diagnostic reasoning, triage differential diagnosis, probabilistic reasoning, and management reasoning, adjudicated by physician experts with validated psychometrics. Our primary outcome was comparison of the o1-preview output to identical prior experiments that have historical human controls and benchmarks of previous LLMs. Significant improvements were observed with differential diagnosis generation and quality of diagnostic and management reasoning. No improvements were observed with probabilistic reasoning or triage differential diagnosis. This study highlights o1-preview's ability to perform strongly on tasks that require complex critical thinking such as diagnosis and management while its performance on probabilistic reasoning tasks was similar to past models. New robust benchmarks and scalable evaluation of LLM capabilities compared to human physicians are needed along with trials evaluating AI in real clinical settings.

Yes! In the present-day documenting and preserving endangered languages, the application of Large Language Models (LLMs) presents a promising approach. This paper explores how LLMs, particularly through in-context learning, can assist in generating grammatical information for low-resource languages with limited amount of data. We takes Moklen as a case study to evaluate the efficacy of LLMs in producing coherent grammatical rules and lexical entries using only bilingual dictionaries and parallel sentences of the unknown language without building the model from scratch. Our methodology involves organising the existing linguistic data and prompting to efficiently enable to generate formal XLE grammar. Our results demonstrate that LLMs can successfully capture key grammatical structures and lexical information, although challenges such as the potential for English grammatical biases remain. This study highlights the potential of LLMs to enhance language documentation efforts, providing a cost-effective solution for generating linguistic data and contributing to the preservation of endangered languages.

Financial sentiment analysis is crucial for understanding the influence of news on stock prices. Recently, large language models (LLMs) have been widely adopted for this purpose due to their advanced text analysis capabilities. However, these models often only consider the news content itself, ignoring its dissemination, which hampers accurate prediction of short-term stock movements. Additionally, current methods often lack sufficient contextual data and explicit instructions in their prompts, limiting LLMs' ability to interpret news. In this paper, we propose a data-driven approach that enhances LLM-powered sentiment-based stock movement predictions by incorporating news dissemination breadth, contextual data, and explicit instructions. We cluster recent company-related news to assess its reach and influence, enriching prompts with more specific data and precise instructions. This data is used to construct an instruction tuning dataset to fine-tune an LLM for predicting short-term stock price movements. Our experimental results show that our approach improves prediction accuracy by 8\% compared to existing methods.

The rapid growth of the financial sector and the rising focus on Environmental, Social, and Governance (ESG) considerations highlight the need for advanced NLP tools. However, open-source LLMs proficient in both finance and ESG domains remain scarce. To address this gap, we introduce SusGen-30K, a category-balanced dataset comprising seven financial NLP tasks and ESG report generation, and propose TCFD-Bench, a benchmark for evaluating sustainability report generation. Leveraging this dataset, we developed SusGen-GPT, a suite of models achieving state-of-the-art performance across six adapted and two off-the-shelf tasks, trailing GPT-4 by only 2% despite using 7-8B parameters compared to GPT-4's 1,700B. Based on this, we propose the SusGen system, integrated with Retrieval-Augmented Generation (RAG), to assist in sustainability report generation. This work demonstrates the efficiency of our approach, advancing research in finance and ESG.

We present BgGPT-Gemma-2-27B-Instruct and BgGPT-Gemma-2-9B-Instruct: continually pretrained and fine-tuned versions of Google's Gemma-2 models, specifically optimized for Bulgarian language understanding and generation. Leveraging Gemma-2's multilingual capabilities and over 100 billion tokens of Bulgarian and English text data, our models demonstrate strong performance in Bulgarian language tasks, setting a new standard for language-specific AI models. Our approach maintains the robust capabilities of the original Gemma-2 models, ensuring that the English language performance remains intact. To preserve the base model capabilities, we incorporate continual learning strategies based on recent Branch-and-Merge techniques as well as thorough curation and selection of training data. We provide detailed insights into our methodology, including the release of model weights with a commercial-friendly license, enabling broader adoption by researchers, companies, and hobbyists. Further, we establish a comprehensive set of benchmarks based on non-public educational data sources to evaluate models on Bulgarian language tasks as well as safety and chat capabilities. Our findings demonstrate the effectiveness of fine-tuning state-of-the-art models like Gemma 2 to enhance language-specific AI applications while maintaining cross-lingual capabilities.