A common approach to selecting examples at The use of in-context learning (ICL) with large inference-time is to generate embeddings of candidate language models (LLMs) has become a popular examples using a model like Sentence-BERT approach to achieve impressive performance in (Reimers, 2019) and retrieve the top-k most similar many NLP tasks (Raffel et al., 2020; Radford et al., examples for a given test instance, ranking them 2019). In ICL, models are prompted during inference based on distance or similarity. However, there is with task-specific examples that help condition a distinction between ranking examples (determining the generated output. Unlike fine-tuning, it how relevant they are to our test case) does not require updates to the model parameters, and ordering them (deciding how to arrange which offers many benefits with ever-increasing them in the prompt).

Drug discovery (DD) has tremendously contributed to maintaining and improving public health. Hypothesizing that inhibiting protein misfolding can slow disease progression, researchers focus on target identification (Target ID) to find protein structures for drug binding. While Large Language Models (LLMs) and Retrieval-Augmented Generation (RAG) frameworks have accelerated drug discovery, integrating models into cohesive workflows remains challenging. We conducted a user study with drug discovery researchers to identify the applicability of LLMs and RAGs in Target ID. We identified two main findings: 1) an LLM should provide multiple Protein-Protein Interactions (PPIs) based on an initial protein and protein candidates that have a therapeutic impact; 2) the model must provide the PPI and relevant explanations for better understanding. Based on these observations, we identified three limitations in previous approaches for Target ID: 1) semantic ambiguity, 2) lack of explainability, and 3) short retrieval units. To address these issues, we propose GraPPI, a large-scale knowledge graph (KG)-based retrieve-divide-solve agent pipeline RAG framework to support large-scale PPI signaling pathway exploration in understanding therapeutic impacts by decomposing the analysis of entire PPI pathways into sub-tasks focused on the analysis of PPI edges.

Dense retrievers have demonstrated significant potential for neural information retrieval; however, they exhibit a lack of robustness to domain shifts, thereby limiting their efficacy in zero-shot settings across diverse domains. A state-of-the-art domain adaptation technique is Generative Pseudo Labeling (GPL). GPL uses synthetic query generation and initially mined hard negatives to distill knowledge from cross-encoder to dense retrievers in the target domain. In this paper, we analyze the documents retrieved by the domain-adapted model and discover that these are more relevant to the target queries than those of the non-domain-adapted model. We then propose refreshing the hard-negative index during the knowledge distillation phase to mine better hard negatives. Our remining R-GPL approach boosts ranking performance in 13/14 BEIR datasets and 9/12 LoTTe datasets. Our contributions are (i) analyzing hard negatives returned by domain-adapted and non-domain-adapted models and (ii) applying the GPL training with and without hard-negative re-mining in LoTTE and BEIR datasets.

In real-world settings, vision language models (VLMs) should robustly handle naturalistic, noisy visual content as well as domain-specific language and concepts. For example, K-12 educators using digital learning platforms may need to examine and provide feedback across many images of students' math work. To assess the potential of VLMs to support educators in settings like this one, we introduce DrawEduMath, an English-language dataset of 2,030 images of students' handwritten responses to K-12 math problems. Teachers provided detailed annotations, including free-form descriptions of each image and 11,661 question-answer (QA) pairs. These annotations capture a wealth of pedagogical insights, ranging from students' problem-solving strategies to the composition of their drawings, diagrams, and writing. We evaluate VLMs on teachers' QA pairs, as well as 44,362 synthetic QA pairs derived from teachers' descriptions using language models (LMs). We show that even state-of-the-art VLMs leave much room for improvement on DrawEduMath questions. We also find that synthetic QAs, though imperfect, can yield similar model rankings as teacher-written QAs. We release DrawEduMath to support the evaluation of VLMs' abilities to reason mathematically over images gathered with educational contexts in mind.

Scaling the capacity of language models has consistently proven to be a reliable approach for improving performance and unlocking new capabilities. Capacity can be primarily defined by two dimensions: the number of model parameters and the compute per example. While scaling typically involves increasing both, the precise interplay between these factors and their combined contribution to overall capacity remains not fully understood. We explore this relationship in the context of sparse Mixture-of-Experts (MoEs), which allow scaling the number of parameters without proportionally increasing the FLOPs per example. We investigate how varying the sparsity level, i.e., the fraction of inactive parameters, impacts model's performance during pretraining and downstream few-shot evaluation. We find that under different constraints (e.g., parameter size and total training compute), there is an optimal level of sparsity that improves both training efficiency and model performance. These results provide a better understanding of the impact of sparsity in scaling laws for MoEs and complement existing works in this area, offering insights for designing more efficient architectures.

Despite their impressive performance on multi-modal tasks, large vision-language models (LVLMs) tend to suffer from hallucinations. An important type is object hallucination, where LVLMs generate objects that are inconsistent with the images shown to the model. Existing works typically attempt to quantify object hallucinations by detecting and measuring the fraction of hallucinated objects in generated captions. Additionally, more recent work also measures object hallucinations by directly querying the LVLM with binary questions about the presence of likely hallucinated objects based on object statistics like top-k frequent objects and top-k co-occurring objects. In this paper, we present Context-Aware Object Similarities (CAOS), a novel approach for evaluating object hallucination in LVLMs using object statistics as well as the generated captions. CAOS uniquely integrates object statistics with semantic relationships between objects in captions and ground-truth data. Moreover, existing approaches usually only detect and measure hallucinations belonging to a predetermined set of in-domain objects (typically the set of all ground-truth objects for the training dataset) and ignore generated objects that are not part of this set, leading to under-evaluation. To address this, we further employ language model--based object recognition to detect potentially out-of-domain hallucinated objects and use an ensemble of LVLMs for verifying the presence of such objects in the query image. CAOS also examines the sequential dynamics of object generation, shedding light on how the order of object appearance influences hallucinations, and employs word embedding models to analyze the semantic reasons behind hallucinations. CAOS aims to offer a nuanced understanding of the hallucination tendencies of LVLMs by providing a systematic framework to identify and interpret object hallucinations.

Vision-language models (VLMs) show remarkable performance in multimodal tasks. However, excessively long multimodal inputs lead to oversized Key-Value (KV) caches, resulting in significant memory consumption and I/O bottlenecks. Previous KV quantization methods for Large Language Models (LLMs) may alleviate these issues but overlook the attention saliency differences of multimodal tokens, resulting in suboptimal performance. In this paper, we investigate the attention-aware token saliency patterns in VLM and propose AKVQ-VL. AKVQ-VL leverages the proposed Text-Salient Attention (TSA) and Pivot-Token-Salient Attention (PSA) patterns to adaptively allocate bit budgets. Moreover, achieving extremely low-bit quantization requires effectively addressing outliers in KV tensors. AKVQ-VL utilizes the Walsh-Hadamard transform (WHT) to construct outlier-free KV caches, thereby reducing quantization difficulty. Evaluations of 2-bit quantization on 12 long-context and multimodal tasks demonstrate that AKVQ-VL maintains or even improves accuracy, outperforming LLM-oriented methods. AKVQ-VL can reduce peak memory usage by 2.13x, support up to 3.25x larger batch sizes and 2.46x throughput.

We introduce Feasible Learning (FL), a sample-centric learning paradigm where models are trained by solving a feasibility problem that bounds the loss for each training sample. In contrast to the ubiquitous Empirical Risk Minimization (ERM) framework, which optimizes for average performance, FL demands satisfactory performance on every individual data point. Since any model that meets the prescribed performance threshold is a valid FL solution, the choice of optimization algorithm and its dynamics play a crucial role in shaping the properties of the resulting solutions. In particular, we study a primal-dual approach which dynamically re-weights the importance of each sample during training. To address the challenge of setting a meaningful threshold in practice, we introduce a relaxation of FL that incorporates slack variables of minimal norm. Our empirical analysis, spanning image classification, age regression, and preference optimization in large language models, demonstrates that models trained via FL can learn from data while displaying improved tail behavior compared to ERM, with only a marginal impact on average performance.

OpenAI has begun previewing a new tool called Operator that can navigate within a web browser. According to a blog post published Thursday, the software is powered by what the company calls a Computer-Using Agent. "CUA is trained to interact with graphical user interfaces (GUIs) -- the buttons, menus, and text fields people see on a screen -- just as humans do," says OpenAI of the model. "This gives it the flexibility to perform digital tasks without using OS- or web-specific APIs." The current release of Operator builds on OpenAI's GPT-4o model.

This week, OpenAI and other tech companies joined US president Donald Trump at the White House to pledge a private investment of half a trillion dollars in US data centres over the next four years. The "Stargate Project" could power an ambitious expansion of AI technology – with repercussions for the US electricity grid and the country's energy future. The Stargate announcement comes as North America has been experiencing surging electricity demand in recent years.