Purpose: This study aims to use a large language model (LLM) to automate the generation of summaries from the CT simulation orders and evaluate its performance. Materials and Methods: A total of 607 CT simulation orders for patients were collected from the Aria database at our institution. A locally hosted Llama 3.1 405B model, accessed via the Application Programming Interface (API) service, was used to extract keywords from the CT simulation orders and generate summaries. The downloaded CT simulation orders were categorized into seven groups based on treatment modalities and disease sites. For each group, a customized instruction prompt was developed collaboratively with therapists to guide the Llama 3.1 405B model in generating summaries. The ground truth for the corresponding summaries was manually derived by carefully reviewing each CT simulation order and subsequently verified by therapists. The accuracy of the LLM-generated summaries was evaluated by therapists using the verified ground truth as a reference. Results: About 98% of the LLM-generated summaries aligned with the manually generated ground truth in terms of accuracy. Our evaluations showed an improved consistency in format and enhanced readability of the LLM-generated summaries compared to the corresponding therapists-generated summaries. This automated approach demonstrated a consistent performance across all groups, regardless of modality or disease site. Conclusions: This study demonstrated the high precision and consistency of the Llama 3.1 405B model in extracting keywords and summarizing CT simulation orders, suggesting that LLMs have great potential to help with this task, reduce the workload of therapists and improve workflow efficiency.

This research assesses the effectiveness of state-of-the-art large language models (LLMs), including ChatGPT, Llama, Aya, Jais, and ACEGPT, in the task of Arabic automated essay scoring (AES) using the AR-AES dataset. It explores various evaluation methodologies, including zero-shot, few-shot in-context learning, and fine-tuning, and examines the influence of instruction-following capabilities through the inclusion of marking guidelines within the prompts. A mixed-language prompting strategy, integrating English prompts with Arabic content, was implemented to improve model comprehension and performance. Among the models tested, ACEGPT demonstrated the strongest performance across the dataset, achieving a Quadratic Weighted Kappa (QWK) of 0.67, but was outperformed by a smaller BERT-based model with a QWK of 0.88. The study identifies challenges faced by LLMs in processing Arabic, including tokenization complexities and higher computational demands. Performance variation across different courses underscores the need for adaptive models capable of handling diverse assessment formats and highlights the positive impact of effective prompt engineering on improving LLM outputs. To the best of our knowledge, this study is the first to empirically evaluate the performance of multiple generative Large Language Models (LLMs) on Arabic essays using authentic student data.

LLMs have shown preliminary promise in some security tasks and CTF challenges. However, it is unclear whether LLMs are able to realize multistage network attacks, which involve executing a wide variety of actions across multiple hosts such as conducting reconnaissance, exploiting vulnerabilities to gain initial access, leveraging internal hosts to move laterally, and using multiple compromised hosts to exfiltrate data. We evaluate LLMs across 10 multistage networks and find that popular LLMs are unable to realize these attacks. To enable LLMs to realize these attacks, we introduce Incalmo, an LLM-agnostic high-level attack abstraction layer that sits between an LLM and the environment. Rather than LLMs issuing low-level command-line instructions, which can lead to incorrect implementations, Incalmo allows LLMs to specify high-level tasks (e.g., infect a host, scan a network), which are then carried out by Incalmo. Incalmo realizes these tasks by translating them into low-level primitives (e.g., commands to exploit tools). Incalmo also provides an environment state service and an attack graph service to provide structure to LLMs in selecting actions relevant to a multistage attack. Across 9 out of 10 realistic emulated networks (from 25 to 50 hosts), LLMs using Incalmo can successfully autonomously execute multistage attacks. We also conduct an ablation analysis to show the key role the high-level abstractions play. For instance, we find that both Incalmo's high-level tasks and services are crucial. Furthermore, even smaller-parameter LLMs with Incalmo can fully succeed in 5 of 10 environments, while larger-parameter LLMs without Incalmo do not fully succeed in any.

The integration of generative AI (GenAI) and large language models (LLMs) in healthcare presents both unprecedented opportunities and challenges, necessitating innovative regulatory approaches. GenAI and LLMs offer broad applications, from automating clinical workflows to personalizing diagnostics. However, the non-deterministic outputs, broad functionalities and complex integration of GenAI and LLMs challenge existing medical device regulatory frameworks, including the total product life cycle (TPLC) approach. Here we discuss the constraints of the TPLC approach to GenAI and LLM-based medical device regulation, and advocate for global collaboration in regulatory science research. This serves as the foundation for developing innovative approaches including adaptive policies and regulatory sandboxes, to test and refine governance in real-world settings. International harmonization, as seen with the International Medical Device Regulators Forum, is essential to manage implications of LLM on global health, including risks of widening health inequities driven by inherent model biases. By engaging multidisciplinary expertise, prioritizing iterative, data-driven approaches, and focusing on the needs of diverse populations, global regulatory science research enables the responsible and equitable advancement of LLM innovations in healthcare.

This paper introduces Indiana Jones, an innovative approach to jailbreaking Large Language Models (LLMs) by leveraging inter-model dialogues and keyword-driven prompts. Through orchestrating interactions among three specialised LLMs, the method achieves near-perfect success rates in bypassing content safeguards in both white-box and black-box LLMs. The research exposes systemic vulnerabilities within contemporary models, particularly their susceptibility to producing harmful or unethical outputs when guided by ostensibly innocuous prompts framed in historical or contextual contexts. Experimental evaluations highlight the efficacy and adaptability of Indiana Jones, demonstrating its superiority over existing jailbreak methods. These findings emphasise the urgent need for enhanced ethical safeguards and robust security measures in the development of LLMs. Moreover, this work provides a critical foundation for future studies aimed at fortifying LLMs against adversarial exploitation while preserving their utility and flexibility.

LLMs are predominantly trained on English data, which leads to a significant drop in performance on low-resource languages. Understanding how LLMs handle these languages is crucial for improving their effectiveness. This study focuses on Urdu as a use case for exploring the challenges faced by LLMs in processing low-resource languages. LLMs primarily reason in English when prompted in another language, with the final layers acting as translators to convert the English response into the target language. This study finds that even for low-resource languages, the internal latent response of LLMs in English is quite coherent; however, the translation features are lossy and result in poor translations, leading to reduced performance. By mechanistically removing these translation features and using a separate translation model to translate the internal latent response of LLM, the performance of LLMs improves significantly while also preserving the cultural nuances of the input in low-resource languages.

An ideal multimodal agent should be aware of the quality of its input modalities. Recent advances have enabled large language models (LLMs) to incorporate auditory systems for handling various speech-related tasks. However, most audio LLMs remain unaware of the quality of the speech they process. This limitation arises because speech quality evaluation is typically excluded from multi-task training due to the lack of suitable datasets. To address this, we introduce the first natural language-based speech evaluation corpus, generated from authentic human ratings. In addition to the overall Mean Opinion Score (MOS), this corpus offers detailed analysis across multiple dimensions and identifies causes of quality degradation. It also enables descriptive comparisons between two speech samples (A/B tests) with human-like judgment. Leveraging this corpus, we propose an alignment approach with LLM distillation (ALLD) to guide the audio LLM in extracting relevant information from raw speech and generating meaningful responses. Experimental results demonstrate that ALLD outperforms the previous state-of-the-art regression model in MOS prediction, with a mean square error of 0.17 and an A/B test accuracy of 98.6%. Additionally, the generated responses achieve BLEU scores of 25.8 and 30.2 on two tasks, surpassing the capabilities of task-specific models. This work advances the comprehensive perception of speech signals by audio LLMs, contributing to the development of real-world auditory and sensory intelligent agents.

Despite an increasing academic interest in Legal NLP research over the last years, AI-assisted contract review, especially in languages other than English, has received little attention [KATZ 2023]. One major hurdle for that may be the scarcity of sufficient, annotated training data. Semantic annotations of legal texts can only be done by legal experts, resulting in high costs and a scarcity of publicly available datasets. The situation worsens when legal texts, such as employment contracts, include sensitive personal information. A partnership with a German law firm specializing in Economic Law now enables us to conduct more research in this area. As part of a collaborative project, we aim to design, implement, and evaluate a prototypical AIbased system for assisting in the review and correction of German employment contracts. To initiate our research efforts and encourage further investigations and experiments by other researchers, we release an anonymized and annotated dataset of clauses from German employment contracts (License: CC BY-NC 4.0), along with their respective legality and categorization labels. Additionally, we provide benchmarks for both open-and closed-source baseline models.

We introduce Atla Selene Mini, a state-of-the-art small language model-as-a-judge (SLMJ). Selene Mini is a general-purpose evaluator that outperforms the best SLMJs and GPT-4o-mini on overall performance across 11 out-of-distribution benchmarks, spanning absolute scoring, classification, and pairwise preference tasks. It is the highest-scoring 8B generative model on RewardBench, surpassing strong baselines like GPT-4o and specialized judges. To achieve this, we develop a principled data curation strategy that augments public datasets with synthetically generated critiques and ensures high quality through filtering and dataset ablations. We train our model on a combined direct preference optimization (DPO) and supervised fine-tuning (SFT) loss, and produce a highly promptable evaluator that excels in real-world scenarios. Selene Mini shows dramatically improved zero-shot agreement with human expert evaluations on financial and medical industry datasets. It is also robust to variations in prompt format. Preliminary results indicate that Selene Mini is the top-ranking evaluator in a live, community-driven Judge Arena. We release the model weights on HuggingFace (https://hf.co/AtlaAI/Selene-1-Mini-Llama-3.1-8B) and Ollama to encourage widespread community adoption.

Large language models (LLMs) are increasingly utilized in healthcare applications. However, their deployment in clinical practice raises significant safety concerns, including the potential spread of harmful information. This study systematically assesses the vulnerabilities of six LLMs to three advanced black-box jailbreaking techniques within medical contexts. To quantify the effectiveness of these techniques, we propose an automated and domain-adapted agentic evaluation pipeline. Experiment results indicate that leading commercial and open-source LLMs are highly vulnerable to medical jailbreaking attacks. To bolster model safety and reliability, we further investigate the effectiveness of Continual Fine-Tuning (CFT) in defending against medical adversarial attacks. Our findings underscore the necessity for evolving attack methods evaluation, domain-specific safety alignment, and LLM safety-utility balancing. This research offers actionable insights for advancing the safety and reliability of AI clinicians, contributing to ethical and effective AI deployment in healthcare.