Natural language interaction with sensing systems is crucial for enabling all users to comprehend sensor data and its impact on their everyday lives. However, existing systems, which typically operate in a Question Answering (QA) manner, are significantly limited in terms of the duration and complexity of sensor data they can handle. In this work, we introduce SensorChat, the first end-to-end QA system designed for long-term sensor monitoring with multimodal and high-dimensional data including time series. SensorChat effectively answers both qualitative (requiring high-level reasoning) and quantitative (requiring accurate responses derived from sensor data) questions in real-world scenarios. To achieve this, SensorChat uses an innovative three-stage pipeline that includes question decomposition, sensor data query, and answer assembly. The first and third stages leverage Large Language Models (LLMs) for intuitive human interactions and to guide the sensor data query process. Unlike existing multimodal LLMs, SensorChat incorporates an explicit query stage to precisely extract factual information from long-duration sensor data. We implement SensorChat and demonstrate its capability for real-time interactions on a cloud server while also being able to run entirely on edge platforms after quantization. Comprehensive QA evaluations show that SensorChat achieves up to 26% higher answer accuracy than state-of-the-art systems on quantitative questions. Additionally, a user study with eight volunteers highlights SensorChat's effectiveness in handling qualitative and open-ended questions.

Chest X-rays (CXRs) play an integral role in driving critical decisions in disease management and patient care. While recent innovations have led to specialized models for various CXR interpretation tasks, these solutions often operate in isolation, limiting their practical utility in clinical practice. We present MedRAX, the first versatile AI agent that seamlessly integrates state-of-the-art CXR analysis tools and multimodal large language models into a unified framework. MedRAX dynamically leverages these models to address complex medical queries without requiring additional training. To rigorously evaluate its capabilities, we introduce ChestAgentBench, a comprehensive benchmark containing 2,500 complex medical queries across 7 diverse categories. Our experiments demonstrate that MedRAX achieves state-of-the-art performance compared to both open-source and proprietary models, representing a significant step toward the practical deployment of automated CXR interpretation systems. Data and code have been publicly available at https://github.com/bowang-lab/MedRAX

We provide a new LLM-compression solution via SVD, unlocking new possibilities for LLM compression beyond quantization and pruning. We point out that the optimal use of SVD lies in truncating activations, rather than merely using activations as an optimization distance. Building on this principle, we address three critical challenges in SVD-based LLM compression: including (1) How can we determine the optimal activation truncation position for each weight matrix in LLMs? (2) How can we efficiently reconstruct the weight matrices based on truncated activations? (3) How can we address the inherent "injection" nature that results in the information loss of the SVD? We propose Dobi-SVD, which establishes a new, principled approach to SVD-based LLM compression.

Methods from machine learning (ML) have transformed the implementation of Perception-Cognition-Communication-Action loops in Cyber-Physical Systems (CPS) and the Internet of Things (IoT), replacing mechanistic and basic statistical models with those derived from data. However, the first generation of ML approaches, which depend on supervised learning with annotated data to create task-specific models, faces significant limitations in scaling to the diverse sensor modalities, deployment configurations, application tasks, and operating dynamics characterizing real-world CPS-IoT systems. The success of task-agnostic foundation models (FMs), including multimodal large language models (LLMs), in addressing similar challenges across natural language, computer vision, and human speech has generated considerable enthusiasm for and exploration of FMs and LLMs as flexible building blocks in CPS-IoT analytics pipelines, promising to reduce the need for costly task-specific engineering. Nonetheless, a significant gap persists between the current capabilities of FMs and LLMs in the CPS-IoT domain and the requirements they must meet to be viable for CPS-IoT applications. In this paper, we analyze and characterize this gap through a thorough examination of the state of the art and our research, which extends beyond it in various dimensions. Based on the results of our analysis and research, we identify essential desiderata that CPS-IoT domain-specific FMs and LLMs must satisfy to bridge this gap. We also propose actions by CPS-IoT researchers to collaborate in developing key community resources necessary for establishing FMs and LLMs as foundational tools for the next generation of CPS-IoT systems.

The rapid evolution of large language models (LLMs) has transformed conversational agents, enabling complex human-machine interactions. However, evaluation frameworks often focus on single tasks, failing to capture the dynamic nature of multi-turn dialogues. This paper introduces a dynamic benchmarking framework to assess LLM-based conversational agents through interactions with synthetic users. The framework integrates generative agent simulation to evaluate performance on key dimensions: information extraction, context awareness, and adaptive engagement. By simulating various aspects of user behavior, our work provides a scalable, automated, and flexible benchmarking approach. Experimental evaluation - within a loan application use case - demonstrates the framework's effectiveness under one-shot and few-shot extraction conditions. Results show that adaptive strategies improve data extraction accuracy, especially when handling ambiguous responses. Future work will extend its applicability to broader domains and incorporate additional metrics (e.g., conversational coherence, user engagement). This study contributes a structured, scalable approach to evaluating LLM-based conversational agents, facilitating real-world deployment.

Large language models (LLMs) have shown remarkable success in language modelling due to scaling laws found in model size and the hidden dimension of the model's text representation. Yet, we demonstrate that compressed representations of text can yield better performance in LLM-based regression tasks. In this paper, we compare the relative performance of embedding compression in three different signal-to-noise contexts: financial return prediction, writing quality assessment and review scoring. Our results show that compressing embeddings, in a minimally supervised manner using an autoencoder's hidden representation, can mitigate overfitting and improve performance on noisy tasks, such as financial return prediction; but that compression reduces performance on tasks that have high causal dependencies between the input and target data. Our results suggest that the success of interpretable compressed representations such as sentiment may be due to a regularising effect.

Purpose: This commentary introduces how artificial intelligence (AI) can be leveraged to advance cross-language intelligibility assessment of dysarthric speech. Method: We propose a conceptual framework consisting of a universal model that captures language-universal speech impairments and a language-specific intelligibility model that incorporates linguistic nuances. Additionally, we identify key barriers to cross-language intelligibility assessment, including data scarcity, annotation complexity, and limited linguistic insights, and present AI-driven solutions to overcome these challenges. Conclusion: Advances in AI offer transformative opportunities to enhance cross-language intelligibility assessment for dysarthric speech by balancing scalability across languages and adaptability by languages.

Decomposing hard problems into subproblems often makes them easier and more efficient to solve. With large language models (LLMs) crossing critical reliability thresholds for a growing slate of capabilities, there is an increasing effort to decompose systems into sets of LLM-based agents, each of whom can be delegated sub-tasks. However, this decomposition (even when automated) is often intuitive, e.g., based on how a human might assign roles to members of a human team. How close are these role decompositions to optimal? This position paper argues that asymptotic analysis with LLM primitives is needed to reason about the efficiency of such decomposed systems, and that insights from such analysis will unlock opportunities for scaling them. By treating the LLM forward pass as the atomic unit of computational cost, one can separate out the (often opaque) inner workings of a particular LLM from the inherent efficiency of how a set of LLMs are orchestrated to solve hard problems. In other words, if we want to scale the deployment of LLMs to the limit, instead of anthropomorphizing LLMs, asymptotic analysis with LLM primitives should be used to reason about and develop more powerful decompositions of large problems into LLM agents.

Recent advances in Large Language Models (LLMs) have motivated the development of general LLMs for molecular tasks. While several studies have demonstrated that fine-tuned LLMs can achieve impressive benchmark performances, they are far from genuine generalist molecular LLMs due to a lack of fundamental understanding of molecular structure. Specifically, when given molecular task instructions, LLMs trained with naive next-token prediction training assign similar likelihood scores to both original and negatively corrupted molecules, revealing their lack of molecular structure understanding that is crucial for reliable and general molecular LLMs. To overcome this limitation and obtain a true generalist molecular LLM, we introduce a novel multi-modal training method based on a thorough multi-modal instruction tuning as well as a molecular structure preference optimization between chosen and rejected graphs. On various molecular benchmarks, the proposed generalist molecular LLM, called Mol-LLM, achieves state-of-the-art performances among generalist LLMs on most tasks, at the same time, surpassing or comparable to state-of-the-art specialist LLMs. Moreover, Mol-LLM also shows superior generalization performances in reaction prediction tasks, demonstrating the effect of the molecular structure understanding for generalization perspective.

Language agents have become a promising solution to complex interactive tasks. One of the key ingredients to the success of language agents is the reward model on the trajectory of the agentic workflow, which provides valuable guidance during training or inference. However, due to the lack of annotations of intermediate interactions, most existing works use an outcome reward model to optimize policies across entire trajectories. This may lead to sub-optimal policies and hinder the overall performance. To address this, we propose QLASS (Q-guided Language Agent Stepwise Search), to automatically generate annotations by estimating Q-values in a stepwise manner for open language agents. By introducing a reasoning tree and performing process reward modeling, QLASS provides effective intermediate guidance for each step. With the stepwise guidance, we propose a Q-guided generation strategy to enable language agents to better adapt to long-term value, resulting in significant performance improvement during model inference on complex interactive agent tasks. Notably, even with almost half the annotated data, QLASS retains strong performance, demonstrating its efficiency in handling limited supervision. We also empirically demonstrate that QLASS can lead to more effective decision making through qualitative analysis. We will release our code and data.