Solving complex tasks in a single attempt is challenging for large language models (LLMs). Iterative interaction with the environment and feedback is often required to achieve success, making effective feedback utilization a critical topic. Existing approaches either struggle with length generalization or rely on naive retries without leveraging prior information. In this paper, we introduce FTTT, a novel paradigm that formulates feedback utilization as an optimization problem at test time. Additionally, we propose a learnable test-time optimizer, OpTune, to effectively exploit feedback. Experiments on two LLMs across four reasoning datasets demonstrate that FTTT and OpTune achieve superior scalability and performance.

In this paper, we leverage recent advancements in feature monosemanticity to extract interpretable features from deep multimodal models, offering a data-driven understanding of modality gaps. Specifically, we investigate CLIP (Contrastive Language-Image Pretraining), a prominent visual-language representation model trained on extensive image-text pairs. Building upon interpretability tools developed for single-modal models, we extend these methodologies to assess multi-modal interpretability of CLIP features. Additionally, we introduce the Modality Dominance Score (MDS) to attribute the interpretability of each feature to its respective modality. Next, we transform CLIP features into a more interpretable space, enabling us to categorize them into three distinct classes: vision features (single-modal), language features (single-modal), and visual-language features (cross-modal). Our findings reveal that this categorization aligns closely with human cognitive understandings of different modalities. We also demonstrate significant use cases of this modality-specific features including detecting gender bias, adversarial attack defense and text-to-image model editing. These results indicate that large-scale multimodal models, equipped with task-agnostic interpretability tools, offer valuable insights into key connections and distinctions between different modalities.

Diffusion models have recently emerged as powerful frameworks for generating high-quality images. While recent studies have explored their application to time series forecasting, these approaches face significant challenges in cross-modal modeling and transforming visual information effectively to capture temporal patterns. In this paper, we propose LDM4TS, a novel framework that leverages the powerful image reconstruction capabilities of latent diffusion models for vision-enhanced time series forecasting. Instead of introducing external visual data, we are the first to use complementary transformation techniques to convert time series into multi-view visual representations, allowing the model to exploit the rich feature extraction capabilities of the pre-trained vision encoder. Subsequently, these representations are reconstructed using a latent diffusion model with a cross-modal conditioning mechanism as well as a fusion module. Experimental results demonstrate that LDM4TS outperforms various specialized forecasting models for time series forecasting tasks.

As automated trading gains traction in the financial market, algorithmic investment strategies are increasingly prominent. While Large Language Models (LLMs) and Agent-based models exhibit promising potential in real-time market analysis and trading decisions, they still experience a significant -20% loss when confronted with rapid declines or frequent fluctuations, impeding their practical application. Hence, there is an imperative to explore a more robust and resilient framework. This paper introduces an innovative multi-agent system, HedgeAgents, aimed at bolstering system robustness via ``hedging'' strategies. In this well-balanced system, an array of hedging agents has been tailored, where HedgeAgents consist of a central fund manager and multiple hedging experts specializing in various financial asset classes. These agents leverage LLMs' cognitive capabilities to make decisions and coordinate through three types of conferences. Benefiting from the powerful understanding of LLMs, our HedgeAgents attained a 70% annualized return and a 400% total return over a period of 3 years. Moreover, we have observed with delight that HedgeAgents can even formulate investment experience comparable to those of human experts (https://hedgeagents.github.io/).

Large Language Models (LLMs) have achieved remarkable success in various domains but remain vulnerable to adversarial jailbreak attacks. Existing prompt-defense strategies, including parameter-modifying and parameter-free approaches, face limitations in adaptability, interpretability, and customization, constraining their effectiveness against evolving threats. To address these challenges, we propose ShieldLearner, a novel paradigm that mimics human learning in defense. Through trial and error, it autonomously distills attack signatures into a Pattern Atlas and synthesizes defense heuristics into a Meta-analysis Framework, enabling systematic and interpretable threat detection. Furthermore, we introduce Adaptive Adversarial Augmentation to generate adversarial variations of successfully defended prompts, enabling continuous self-improvement without model retraining. In addition to standard benchmarks, we create a hard test set by curating adversarial prompts from the Wildjailbreak dataset, emphasizing more concealed malicious intent. Experimental results show that ShieldLearner achieves a significantly higher defense success rate than existing baselines on both conventional and hard test sets, while also operating with lower computational overhead, making it a practical and efficient solution for real-world adversarial defense.

Prompt tuning (PT) offers a cost-effective alternative to fine-tuning large-scale pre-trained language models (PLMs), requiring only a few parameters in soft prompt tokens added before the input text. However, existing PT approaches face two significant issues: (i) They overlook intrinsic semantic associations between soft prompt tokens, leading to high discreteness and limited interactions, thus reducing the model's comprehension and effectiveness in complex tasks. (ii) Due to the complexity of downstream tasks, long soft prompt is necessitated to improve performance, but prompt length correlates positively with memory usage and computational costs. Achieving high efficiency and performance remains an ongoing challenge. To address these issues, we propose a novel Low-parameters prompt tuning (LAMP) method, which leverages prompt decomposition and compressed outer product. Specifically, the prompt decomposition module employs Truncated SVD to reduce training parameters and significantly lower the dimensionality of the soft prompt parameter space. It then utilizes a compressed outer product module to facilitate multiple interactions among prompt tokens, exploring their intrinsic associations to enhance knowledge representation. Finally, LAMP uses average pooling to reduce memory usage and training/inference time. Extensive experiments across six architectures and eight datasets demonstrate that LAMP outperforms state-of-the-art PT-based and LoRA-based methods in performance and efficiency.

Due to the rise in antimicrobial resistance, identifying novel compounds with antibiotic potential is crucial for combatting this global health issue. However, traditional drug development methods are costly and inefficient. Recognizing the pressing need for more effective solutions, researchers have turned to machine learning techniques to streamline the prediction and development of novel antibiotic compounds. While foundation models have shown promise in antibiotic discovery, current mainstream efforts still fall short of fully leveraging the potential of multimodal molecular data. Recent studies suggest that contrastive learning frameworks utilizing multimodal data exhibit excellent performance in representation learning across various domains. Building upon this, we introduce CL-MFAP, an unsupervised contrastive learning (CL)-based multimodal foundation (MF) model specifically tailored for discovering small molecules with potential antibiotic properties (AP) using three types of molecular data. This model employs 1.6 million bioactive molecules with drug-like properties from the ChEMBL dataset to jointly pretrain three encoders: (1) a transformer-based encoder with rotary position embedding for processing SMILES strings; (2) another transformerbased encoder, incorporating a novel bi-level routing attention mechanism to handle molecular graph representations; and (3) a Morgan fingerprint encoder using a multilayer perceptron, to achieve the contrastive learning purpose. The CL-MFAP outperforms baseline models in antibiotic property prediction by effectively utilizing different molecular modalities and demonstrates superior domain-specific performance when fine-tuned for antibiotic-related property prediction tasks. Bacteria play a pivotal role in a diverse array of diseases within the human body, serving as either the primary cause or a contributing factor. A promising and sometimes sole treatment for these diseases is antibiotics, a specialized class of drugs designed to target pathogenic bacteria. Despite advancements, a lack of antibiotics for many pathogenic bacteria persists, and antibiotic resistance allows bacteria to survive once effective treatments. Consequently, there is a pressing demand for the continual development of antibiotics.

Current Large Language Model (LLM) agents demonstrate strong reasoning and tool use capabilities, but often lack self-awareness, failing to balance these approaches effectively. This imbalance leads to Tool Overuse, where models unnecessarily rely on external tools for tasks solvable with parametric knowledge, increasing computational overhead. Inspired by human metacognition, we introduce SMART (Strategic Model-Aware Reasoning with Tools), a paradigm that enhances an agent's self-awareness to optimize task handling and reduce tool overuse. To support this paradigm, we introduce SMART-ER, a dataset spanning three domains, where reasoning alternates between parametric knowledge and tool-dependent steps, with each step enriched by rationales explaining when tools are necessary. Through supervised training, we develop SMARTAgent, a family of models that dynamically balance parametric knowledge and tool use. Evaluations show that SMARTAgent reduces tool use by 24% while improving performance by over 37%, enabling 7B-scale models to match its 70B counterpart and GPT-4o. Additionally, SMARTAgent generalizes to out-of-distribution test data like GSM8K and MINTQA, maintaining accuracy with just one-fifth the tool calls. These highlight the potential of strategic tool use to enhance reasoning, mitigate overuse, and bridge the gap between model size and performance, advancing intelligent and resource-efficient agent designs.

This study explores a novel approach to enhance the performance of Large Language Models (LLMs) through the optimization of input data within prompts. While previous research has primarily focused on refining instruction components and augmenting input data with in-context examples, our work investigates the potential benefits of optimizing the input data itself. We introduce a two-pronged strategy for input data optimization: content engineering and structural reformulation. Content engineering involves imputing missing values, removing irrelevant attributes, and enriching profiles by generating additional information inferred from existing attributes. Subsequent to content engineering, structural reformulation is applied to optimize the presentation of the modified content to LLMs, given their sensitivity to input format. Our findings suggest that these optimizations can significantly improve the performance of LLMs in various tasks, offering a promising avenue for future research in prompt engineering. The source code is available at https://anonymous.4open.science/r/ADO-6BC5/

While the widespread use of Large Language Models (LLMs) brings convenience, it also raises concerns about the credibility of academic research and scholarly processes. To better understand these dynamics, we evaluate the penetration of LLMs across academic workflows from multiple perspectives and dimensions, providing compelling evidence of their growing influence. We propose a framework with two components: \texttt{ScholarLens}, a curated dataset of human- and LLM-generated content across scholarly writing and peer review for multi-perspective evaluation, and \texttt{LLMetrica}, a tool for assessing LLM penetration using rule-based metrics and model-based detectors for multi-dimensional evaluation. Our experiments demonstrate the effectiveness of \texttt{LLMetrica}, revealing the increasing role of LLMs in scholarly processes. These findings emphasize the need for transparency, accountability, and ethical practices in LLM usage to maintain academic credibility.