Large Language Model
DistillNote: LLM-based clinical note summaries improve heart failure diagnosis
Boll, Heloisa Oss, Boll, Antonio Oss, Boll, Leticia Puttlitz, Hanna, Ameen Abu, Calixto, Iacer
Large language models (LLMs) offer unprecedented opportunities to generate concise summaries of patient information and alleviate the burden of clinical documentation that overwhelms healthcare providers. We present Distillnote, a framework for LLM-based clinical note summarization, and generate over 64,000 admission note summaries through three techniques: (1) One-step, direct summarization, and a divide-and-conquer approach involving (2) Structured summarization focused on independent clinical insights, and (3) Distilled summarization that further condenses the Structured summaries. We test how useful are the summaries by using them to predict heart failure compared to a model trained on the original notes. Distilled summaries achieve 79% text compression and up to 18.2% improvement in AUPRC compared to an LLM trained on the full notes. We also evaluate the quality of the generated summaries in an LLM-as-judge evaluation as well as through blinded pairwise comparisons with clinicians. Evaluations indicate that one-step summaries are favoured by clinicians according to relevance and clinical actionability, while distilled summaries offer optimal efficiency (avg. 6.9x compression-to-performance ratio) and significantly reduce hallucinations. We release our summaries on PhysioNet to encourage future research.
Language-Informed Synthesis of Rational Agent Models for Grounded Theory-of-Mind Reasoning On-The-Fly
Ying, Lance, Truong, Ryan, Collins, Katherine M., Zhang, Cedegao E., Wei, Megan, Brooke-Wilson, Tyler, Zhi-Xuan, Tan, Wong, Lionel, Tenenbaum, Joshua B.
Drawing real world social inferences usually requires taking into account information from multiple modalities. Language is a particularly powerful source of information in social settings, especially in novel situations where language can provide both abstract information about the environment dynamics and concrete specifics about an agent that cannot be easily visually observed. In this paper, we propose Language-Informed Rational Agent Synthesis (LIRAS), a framework for drawing context-specific social inferences that integrate linguistic and visual inputs. LIRAS frames multimodal social reasoning as a process of constructing structured but situation-specific agent and environment representations - leveraging multimodal language models to parse language and visual inputs into unified symbolic representations, over which a Bayesian inverse planning engine can be run to produce granular probabilistic judgments. On a range of existing and new social reasoning tasks derived from cognitive science experiments, we find that our model (instantiated with a comparatively lightweight VLM) outperforms ablations and state-of-the-art models in capturing human judgments across all domains.
ReasonGRM: Enhancing Generative Reward Models through Large Reasoning Models
Chen, Bin, Gao, Xinzge, Hu, Chuanrui, Yu, Penghang, Zhang, Hua, Bao, Bing-Kun
Generative Reward Models (GRMs) provide greater flexibility than scalar reward models in capturing human preferences, but their effectiveness is limited by poor reasoning capabilities. This often results in incomplete or overly speculative reasoning paths, leading to hallucinations or missing key information in complex tasks. We address this challenge with ReasonGRM, a three-stage generative reward modeling framework. In the first stage, Zero-RL is used to generate concise, outcome-directed reasoning paths that reduce the likelihood of critical omissions. In the second stage, we introduce a novel evaluation metric, $R^\star$, which scores reasoning paths based on their generation likelihood. This favors paths that reach correct answers with minimal exploration, helping to reduce hallucination-prone data during training. In the final stage, the model is further refined through reinforcement learning on challenging examples to enhance its preference discrimination capabilities. Experiments on three public benchmarks show that ReasonGRM achieves competitive or state-of-the-art performance, outperforming previous best GRMs by 1.8\% on average and surpassing proprietary models such as GPT-4o by up to 5.6\%. These results demonstrate the effectiveness of reasoning-aware training and highlight the importance of high-quality rationale selection for reliable preference modeling.
From Prompts to Constructs: A Dual-Validity Framework for LLM Research in Psychology
Large language models (LLMs) are rapidly being adopted across psychology, serving as research tools, experimental subjects, human simulators, and computational models of cognition. However, the application of human measurement tools to these systems can produce contradictory results, raising concerns that many findings are measurement phantoms--statistical artifacts rather than genuine psychological phenomena. In this Perspective, we argue that building a robust science of AI psychology requires integrating two of our field's foundational pillars: the principles of reliable measurement and the standards for sound causal inference. We present a dual-validity framework to guide this integration, which clarifies how the evidence needed to support a claim scales with its scientific ambition. Using an LLM to classify text may require only basic accuracy checks, whereas claiming it can simulate anxiety demands a far more rigorous validation process. Current practice systematically fails to meet these requirements, often treating statistical pattern matching as evidence of psychological phenomena. The same model output--endorsing "I am anxious"--requires different validation strategies depending on whether researchers claim to measure, characterize, simulate, or model psychological constructs. Moving forward requires developing computational analogues of psychological constructs and establishing clear, scalable standards of evidence rather than the uncritical application of human measurement tools.
A Simple Contrastive Framework Of Item Tokenization For Generative Recommendation
Zhai, Penglong, Yuan, Yifang, Di, Fanyi, Li, Jie, Liu, Yue, Li, Chen, Huang, Jie, Wang, Sicong, Xu, Yao, Li, Xin
Generative retrieval-based recommendation has emerged as a promising paradigm aiming at directly generating the identifiers of the target candidates. However, in large-scale recommendation systems, this approach becomes increasingly cumbersome due to the redundancy and sheer scale of the token space. To overcome these limitations, recent research has explored the use of semantic tokens as an alternative to ID tokens, which typically leveraged reconstruction-based strategies, like RQ-VAE, to quantize content embeddings and significantly reduce the embedding size. However, reconstructive quantization aims for the precise reconstruction of each item embedding independently, which conflicts with the goal of generative retrieval tasks focusing more on differentiating among items. Moreover, multi-modal side information of items, such as descriptive text and images, geographical knowledge in location-based recommendation services, has been shown to be effective in improving recommendations by providing richer contexts for interactions. Nevertheless, effectively integrating such complementary knowledge into existing generative recommendation frameworks remains challenging. To overcome these challenges, we propose a novel unsupervised deep quantization exclusively based on contrastive learning, named SimCIT (a Simple Contrastive Item Tokenization framework). Specifically, different from existing reconstruction-based strategies, SimCIT propose to use a learnable residual quantization module to align with the signals from different modalities of the items, which combines multi-modal knowledge alignment and semantic tokenization in a mutually beneficial contrastive learning framework. Extensive experiments across public datasets and a large-scale industrial dataset from various domains demonstrate SimCIT's effectiveness in LLM-based generative recommendation.
How to Train your Text-to-Image Model: Evaluating Design Choices for Synthetic Training Captions
Brack, Manuel, Katakol, Sudeep, Friedrich, Felix, Schramowski, Patrick, Ravi, Hareesh, Kersting, Kristian, Kale, Ajinkya
Training data is at the core of any successful text-to-image models. The quality and descriptiveness of image text are crucial to a model's performance. Given the noisiness and inconsistency in web-scraped datasets, recent works shifted towards synthetic training captions. While this setup is generally believed to produce more capable models, current literature does not provide any insights into its design choices. This study closes this gap by systematically investigating how different synthetic captioning strategies impact the downstream performance of text-to-image models. Our experiments demonstrate that dense, high-quality captions enhance text alignment but may introduce trade-offs in output aesthetics and diversity. Conversely, captions of randomized lengths yield balanced improvements across aesthetics and alignment without compromising sample diversity. W e also demonstrate that varying caption distributions introduce significant shifts in the output bias of a trained model. Our findings underscore the importance of caption design in achieving optimal model performance and provide practical insights for more effective training data strategies in text-to-image generation.
Arch-Router: Aligning LLM Routing with Human Preferences
Tran, Co, Paracha, Salman, Hafeez, Adil, Chen, Shuguang
With the rapid proliferation of large language models (LLMs) -- each optimized for different strengths, style, or latency/cost profile -- routing has become an essential technique to operationalize the use of different models. However, existing LLM routing approaches are limited in two key ways: they evaluate performance using benchmarks that often fail to capture human preferences driven by subjective evaluation criteria, and they typically select from a limited pool of models. In this work, we propose a preference-aligned routing framework that guides model selection by matching queries to user-defined domains (e.g., travel) or action types (e.g., image editing) -- offering a practical mechanism to encode preferences in routing decisions. Specifically, we introduce \textbf{Arch-Router}, a compact 1.5B model that learns to map queries to domain-action preferences for model routing decisions. Our approach also supports seamlessly adding new models for routing without requiring retraining or architectural modifications. Experiments on conversational datasets demonstrate that our approach achieves state-of-the-art (SOTA) results in matching queries with human preferences, outperforming top proprietary models. Our approach captures subjective evaluation criteria and makes routing decisions more transparent and flexible. Our model is available at: \texttt{https://huggingface.co/katanemo/Arch-Router-1.5B}.
LLMs in Coding and their Impact on the Commercial Software Engineering Landscape
Belozerov, Vladislav, Barclay, Peter J, Sami, Askhan
Large-language-model coding tools are now mainstream in software engineering. But as these same tools move human effort up the development stack, they present fresh dangers: 10% of real prompts leak private data, 42% of generated snippets hide security flaws, and the models can even ``agree'' with wrong ideas, a trait called sycophancy. We argue that firms must tag and review every AI-generated line of code, keep prompts and outputs inside private or on-premises deployments, obey emerging safety regulations, and add tests that catch sycophantic answers -- so they can gain speed without losing security and accuracy.
SemAgent: A Semantics Aware Program Repair Agent
Pabba, Anvith, Mathai, Alex, Chakraborty, Anindya, Ray, Baishakhi
Large Language Models (LLMs) have shown impressive capabilities in downstream software engineering tasks such as Automated Program Repair (APR). In particular, there has been a lot of research on repository-level issue-resolution benchmarks such as SWE-Bench. Although there has been significant progress on this topic, we notice that in the process of solving such issues, existing agentic systems tend to hyper-localize on immediately suspicious lines of code and fix them in isolation, without a deeper understanding of the issue semantics, code semantics, or execution semantics. Consequently, many existing systems generate patches that overfit to the user issue, even when a more general fix is preferable. To address this limitation, we introduce SemAgent, a novel workflow-based procedure that leverages issue, code, and execution semantics to generate patches that are complete - identifying and fixing all lines relevant to the issue. We achieve this through a novel pipeline that (a) leverages execution semantics to retrieve relevant context, (b) comprehends issue-semantics via generalized abstraction, (c) isolates code-semantics within the context of this abstraction, and (d) leverages this understanding in a two-stage architecture: a repair stage that proposes fine-grained fixes, followed by a reviewer stage that filters relevant fixes based on the inferred issue-semantics. Our evaluations show that our methodology achieves a solve rate of 44.66% on the SWEBench-Lite benchmark beating all other workflow-based approaches, and an absolute improvement of 7.66% compared to our baseline, which lacks such deep semantic understanding. We note that our approach performs particularly well on issues requiring multi-line reasoning (and editing) and edge-case handling, suggesting that incorporating issue and code semantics into APR pipelines can lead to robust and semantically consistent repairs.
A Scoping Review of Synthetic Data Generation for Biomedical Research and Applications
Rao, Hanshu, Liu, Weisi, Wang, Haohan, Huang, I-Chan, He, Zhe, Huang, Xiaolei
Synthetic data generation--mitigating data scarcity, privacy concerns, and data quality challenges in biomedical fields--has been facilitated by rapid advances of large language models (LLMs). This scoping review follows PRISMA-ScR guidelines and synthesizes 59 studies, published between 2020 and 2025 and collected from PubMed, ACM, Web of Science, and Google Scholar. The review systematically examines biomedical research and application trends in synthetic data generation, emphasizing clinical applications, methodologies, and evaluations. Our analysis identifies data modalities of unstructured texts (78.0%), tabular data (13.6%), and multimodal sources (8.4%); generation methods of prompting (72.9%), fine-tuning (22.0%) LLMs and specialized model (5.1%); and heterogeneous evaluations of intrinsic metrics (27.1%), human-in-the-loop assessments (55.9%), and LLM-based evaluations (13.6%). The analysis addresses current limitations in what, where, and how health professionals can leverage synthetic data generation for biomedical domains. Our review also highlights challenges in adaption across clinical domains, resource and model accessibility, and evaluation standardizations.