Dynamic Cell Structures (DCS) represent a family of artificial neural architectures suited both for unsupervised and supervised learning. They belong to the recently [Martinetz94] introduced class of Topology Representing Networks (TRN) which build perlectly topology preserving feature maps. DCS empI'oy a modified Kohonen learning rule in conjunction with competitive Hebbian learning. The Kohonen type learning rule serves to adjust the synaptic weight vectors while Hebbian learning establishes a dynamic lateral connection structure between the units reflecting the topology of the feature manifold. In case of supervised learning, i.e. function approximation, each neural unit implements a Radial Basis Function, and an additional layer of linear output units adjusts according to a delta-rule. DCS is the first RBF-based approximation scheme attempting to concurrently learn and utilize a perfectly topology preserving map for improved performance. Simulations on a selection of CMU-Benchmarks indicate that the DCS idea applied to the Growing Cell Structure algorithm [Fritzke93] leads to an efficient and elegant algorithm that can beat conventional models on similar tasks.

We present a new method for obtaining local error bars for nonlinear regression, i.e., estimates of the confidence in predicted values that depend on the input. We approach this problem by applying a maximumlikelihood framework to an assumed distribution of errors. We demonstrate our method first on computer-generated data with locally varying, normally distributed target noise. We then apply it to laser data from the Santa Fe Time Series Competition where the underlying system noise is known quantization error and the error bars give local estimates of model misspecification. In both cases, the method also provides a weightedregression effect that improves generalization performance.

Visualizing and structuring pairwise dissimilarity data are difficult combinatorial optimization problems known as multidimensional scaling or pairwise data clustering. Algorithms for embedding dissimilarity data set in a Euclidian space, for clustering these data and for actively selecting data to support the clustering process are discussed in the maximum entropy framework. Active data selection provides a strategy to discover structure in a data set efficiently with partially unknown data. 1 Introduction Grouping experimental data into compact clusters arises as a data analysis problem in psychology, linguistics, genetics and other experimental sciences. The data which are supposed to be clustered are either given by an explicit coordinate representation (central clustering) or, in the non-metric case, they are characterized by dissimilarity values for pairs of data points (pairwise clustering). In this paper we study algorithms (i) for embedding non-metric data in a D-dimensional Euclidian space, (ii) for simultaneous clustering and embedding of non-metric data, and (iii) for active data selection to determine a particular cluster structure with minimal number of data queries. All algorithms are derived from the maximum entropy principle (Hertz et al., 1991) which guarantees robust statistics (Tikochinsky et al., 1984).

We introduce a recurrent architecture having a modular structure and we formulate a training procedure based on the EM algorithm. The resulting model has similarities to hidden Markov models, but supports recurrent networks processing style and allows to exploit the supervised learning paradigm while using maximum likelihood estimation. 1 INTRODUCTION Learning problems involving sequentially structured data cannot be effectively dealt with static models such as feedforward networks. Recurrent networks allow to model complex dynamical systems and can store and retrieve contextual information in a flexible way. Up until the present time, research efforts of supervised learning for recurrent networks have almost exclusively focused on error minimization by gradient descent methods. Although effective for learning short term memories, practical difficulties have been reported in training recurrent neural networks to perform tasks in which the temporal contingencies present in the input/output sequences span long intervals (Bengio et al., 1994; Mozer, 1992).

The parietal cortex is thought to represent the egocentric positions of objects in particular coordinate systems. We propose an alternative approach to spatial perception of objects in the parietal cortex from the perspective of sensorimotor transformations. The responses of single parietal neurons can be modeled as a gaussian function of retinal position multiplied by a sigmoid function of eye position, which form a set of basis functions. We show here how these basis functions can be used to generate receptive fields in either retinotopic or head-centered coordinates by simple linear transformations. This raises the possibility that the parietal cortex does not attempt to compute the positions of objects in a particular frame of reference but instead computes a general purpose representation of the retinal location and eye position from which any transformation can be synthesized by direct projection. This representation predicts that hemineglect, a neurological syndrome produced by parietal lesions, should not be confined to egocentric coordinates, but should be observed in multiple frames of reference in single patients, a prediction supported by several experiments.

Diagnosis of human disease or machine fault is a missing data problem since many variables are initially unknown. Additional information needs to be obtained. The j oint probability distribution of the data can be used to solve this problem. We model this with mixture models whose parameters are estimated by the EM algorithm. This gives the benefit that missing data in the database itself can also be handled correctly. The request for new information to refine the diagnosis is performed using the maximum utility principle. Since the system is based on learning it is domain independent and less labor intensive than expert systems or probabilistic networks. An example using a heart disease database is presented.

The TNM staging system has been used since the early 1960's to predict breast cancer patient outcome. In an attempt to increase prognostic accuracy, many putative prognostic factors have been identified. Because the TNM stage model can not accommodate these new factors, the proliferation of factors in breast cancer has lead to clinical confusion. What is required is a new computerized prognostic system that can test putative prognostic factors and integrate the predictive factors with the TNM variables in order to increase prognostic accuracy. Using the area under the curve of the receiver operating characteristic, we compare the accuracy of the following predictive models in terms of five year breast cancer-specific survival: pTNM staging system, principal component analysis, classification and regression trees, logistic regression, cascade correlation neural network, conjugate gradient descent neural, probabilistic neural network, and backpropagation neural network. Several statistical models are significantly more ac- 1064 Harry B. Burke, David B. Rosen, Philip H. Goodman

We construct a mixture of locally linear generative models of a collection of pixel-based images of digits, and use them for recognition. Different models of a given digit are used to capture different styles of writing, and new images are classified by evaluating their log-likelihoods under each model. We use an EMbased algorithm in which the M-step is computationally straightforward principal components analysis (PCA). Incorporating tangent-plane information [12] about expected local deformations only requires adding tangent vectors into the sample covariance matrices for the PCA, and it demonstrably improves performance.

Local algorithms such as K-nearest neighbor (NN) perform well in pattern recognition, even though they often assume the simplest distance on the pattern space. It has recently been shown (Simard et al. 1993) that the performance can be further improved by incorporating invariance to specific transformations in the underlying distance metric - the so called tangent distance. The resulting classifier, however, can be prohibitively slow and memory intensive due to the large amount of prototypes that need to be stored and used in the distance comparisons. In this paper we address this problem for the tangent distance algorithm, by developing rich models for representing large subsets of the prototypes. Our leading example of prototype model is a low-dimensional (12) hyperplane defined by a point and a set of basis or tangent vectors.

The problem of interpolating between specified images in an image sequence is a simple, but important task in model-based vision. We describe an approach based on the abstract task of "manifold learning" and present results on both synthetic and real image sequences. This problem arose in the development of a combined lipreading and speech recognition system.