A foundational problem in semi-supervised learning is the construction of a graph underlying the data. We propose to use a method which optimally combines a number of differently constructed graphs.

This paper introduces Gaussian Process Dynamical Models (GPDM) for nonlinear time series analysis. A GPDM comprises a low-dimensional latent space with associated dynamics, and a map from the latent space to an observation space.

We propose a new linear method for dimension reduction to identify non-Gaussian components in high dimensional data. Our method, NGCA (non-Gaussian component analysis), uses a very general semi-parametric framework. In contrast to existing projection methods we define what is uninteresting (Gaussian): by projecting out uninterestingness, we can estimate the relevant non-Gaussian subspace. We show that the estimation error of finding the non-Gaussian components tends to zero at a parametric rate. Once NGCA components are identified and extracted, various tasks can be applied in the data analysis process, like data visualization, clustering, denoising or classification. A numerical study demonstrates the usefulness of our method.

Our understanding of the input-output function of single cells has been substantially advanced by biophysically accurate multi-compartmental models. The large number of parameters needing hand tuning in these models has, however, somewhat hampered their applicability and interpretability. Here we propose a simple and well-founded method for automatic estimation of many of these key parameters: 1) the spatial distribution of channel densities on the cell's membrane; 2) the spatiotemporal pattern of synaptic input; 3) the channels' reversal potentials; 4) the intercompartmental conductances; and 5) the noise level in each compartment. We assume experimental access to: a) the spatiotemporal voltage signal in the dendrite (or some contiguous subpart thereof, e.g.

Probabilistic modeling of correlated neural population firing activity is central to understanding the neural code and building practical decoding algorithms. No parametric models currently exist for modeling multivariate correlated neural data and the high dimensional nature of the data makes fully nonparametric methods impractical. To address these problems we propose an energy-based model in which the joint probability of neural activity is represented using learned functions of the 1D marginal histograms of the data. The parameters of the model are learned using contrastive divergence and an optimization procedure for finding appropriate marginal directions. We evaluate the method using real data recorded from a population of motor cortical neurons. In particular, we model the joint probability of population spiking times and 2D hand position and show that the likelihood of test data under our model is significantly higher than under other models. These results suggest that our model captures correlations in the firing activity. Our rich probabilistic model of neural population activity is a step towards both measurement of the importance of correlations in neural coding and improved decoding of population activity.

Convexity has recently received a lot of attention in the machine learning community, and the lack of convexity has been seen as a major disadvantage of many learning algorithms, such as multi-layer artificial neural networks. We show that training multi-layer neural networks in which the number of hidden units is learned can be viewed as a convex optimization problem. This problem involves an infinite number of variables, but can be solved by incrementally inserting a hidden unit at a time, each time finding a linear classifier that minimizes a weighted sum of errors.

For this purpose, we propose a stochastic procedure, the mirror descent, which performs gradient descent in the dual space. The generated estimates are additionally averaged in a recursive fashion with specific weights. Mirror descent algorithms have been developed in different contexts and they are known to be particularly efficient in high dimensional problems. Moreover their implementation is adapted to the online setting. The main result of the paper is the upper bound on the convergence rate for the generalization error.

We present an infinite mixture model in which each component comprises a multivariate Gaussian distribution over an input space, and a Gaussian Process model over an output space. Our model is neatly able to deal with non-stationary covariance functions, discontinuities, multimodality and overlapping output signals. The work is similar to that by Rasmussen and Ghahramani [1]; however, we use a full generative model over input and output space rather than just a conditional model. This allows us to deal with incomplete data, to perform inference over inverse functional mappings as well as for regression, and also leads to a more powerful and consistent Bayesian specification of the effective'gating network' for the different experts.

We determine the asymptotic limit of the function computed by support vector machines (SVM) and related algorithms that minimize a regularized empirical convex loss function in the reproducing kernel Hilbert space of the Gaussian RBF kernel, in the situation where the number of examples tends to infinity, the bandwidth of the Gaussian kernel tends to 0, and the regularization parameter is held fixed.

We show that Queyranne's algorithm for minimizing symmetric submodular functions can be used for clustering with a variety of different objective functions. Two specific criteria that we consider in this paper are the single linkage and the minimum description length criteria. The first criterion tries to maximize the minimum distance between elements of different clusters, and is inherently "discriminative". It is known that optimal clusterings into k clusters for any given k in polynomial time for this criterion can be computed. The second criterion seeks to minimize the description length of the clusters given a probabilistic generative model. We show that the optimal partitioning into 2 clusters, and approximate partitioning (guaranteed to be within a factor of 2 of the the optimal) for more clusters can be computed. To the best of our knowledge, this is the first time that a tractable algorithm for finding the optimal clustering with respect to the MDL criterion for 2 clusters has been given. Besides the optimality result for the MDL criterion, the chief contribution of this paper is to show that the same algorithm can be used to optimize a broad class of criteria, and hence can be used for many application specific criterion for which efficient algorithm are not known.