The information bottleneck (IB) method is an information-theoretic formulation for clustering problems.

Inner-product operators, often referred to as kernels in statistical learning, define a mapping from some input space into a feature space. The focus of this paper is the construction of biologically-motivated kernels for cortical activities. The kernels we derive, termed Spikernels, map spike count sequences into an abstract vector space in which we can perform various prediction tasks. We discuss in detail the derivation of Spikernels and describe an efficient algorithm for computing their value on any two sequences of neural population spike counts. We demonstrate the merits of our modeling approach using the Spikernel and various standard kernels for the task of predicting hand movement velocities from cortical recordings. In all of our experiments all the kernels we tested outperform the standard scalar product used in regression with the Spikernel consistently achieving the best performance.

By comparison to some other sensory cortices, the functional properties of cells in the primary auditory cortex are not yet well understood. Recent attempts to obtain a generalized description of auditory cortical responses have often relied upon characterization of the spectrotemporal receptive field (STRF), which amounts to a model of the stimulusresponse function (SRF) that is linear in the spectrogram of the stimulus.

We argue that human inductive generalization is best explained in a Bayesian framework, rather than by traditional models based on similarity computations. We go beyond previous work on Bayesian concept learning by introducing an unsupervised method for constructing flexible hypothesis spaces, and we propose a version of the Bayesian Occam's razor that trades off priors and likelihoods to prevent under-or over-generalization in these flexible spaces. We analyze two published data sets on inductive reasoning as well as the results of a new behavioral study that we have carried out.

We propose analysis of information in speech using three sources - language (phone), speaker and channeL Information in speech is measured as mutual information between the source and the set of features extracted from speech signaL We assume that distribution of features can be modeled using Gaussian distribution. The mutual information is computed using the results of analysis of variability in speech. We observe similarity in the results of phone variability and phone information, and show that the results of the proposed analysis have more meaningful interpretations than the analysis of variability. 1 Introduction Speech signal carries information about the linguistic message, the speaker, the communication channeL In the previous work [1, 2], we proposed analysis of information in speech as analysis of variability in a set of features extracted from the speech signal. The variability was measured as covariance of the features, and analysis was performed using using multivariate analysis of variance (MANOVA). Total variability was divided into three types of variabilities, namely, intra-phone (or phone) variability, speaker variability, and channel variability.

We formulate the regression problem as one of maximizing the minimum probability, symbolized by Ω, that future predicted outputs of the regression model will be within some ε bound of the true regression function. Our formulation is unique in that we obtain a direct estimate of this lower probability bound Ω. The proposed framework, minimax probability machine regression (MPMR), is based on the recently described minimax probability machine classification algorithm [Lanckriet et al.] and uses Mercer Kernels to obtain nonlinear regression models. MPMR is tested on both toy and real world data, verifying the accuracy of the Ω bound, and the efficacy of the regression models.

We describe the application of probabilistic model-based learning to the problem of automatically identifying classes of galaxies, based on both morphological and pixel intensity characteristics. The EM algorithm can be used to learn how to spatially orient a set of galaxies so that they are geometrically aligned. We augment this "ordering-model" with a mixture model on objects, and demonstrate how classes of galaxies can be learned in an unsupervised manner using a two-level EM algorithm. The resulting models provide highly accurate classi£cation of galaxies in cross-validation experiments.

We develop a maximum entropy (maxent) approach to generating recommendations in the context of a user's current navigation stream, suitable for environments where data is sparse, high-dimensional, and dynamic-- conditions typical of many recommendation applications. We address sparsity and dimensionality reduction by first clustering items based on user access patterns so as to attempt to minimize the apriori probability that recommendations will cross cluster boundaries and then recommending only within clusters. We address the inherent dynamic nature of the problem by explicitly modeling the data as a time series; we show how this representational expressivity fits naturally into a maxent framework. We conduct experiments on data from ResearchIndex, a popular online repository of over 470,000 computer science documents. We show that our maxent formulation outperforms several competing algorithms in offline tests simulating the recommendation of documents to ResearchIndex users.

We consider two ubiquitous processes: an industrial dryer and a level tank. For these applications, we compared three particle filtering variants: standard particle filtering, Rao-Blackwellised particle filtering and a version of Rao-Blackwellised particle filtering that does one-step look-ahead to select good sampling regions. We show that the overhead of the extra processing per particle of the more sophisticated methods is more than compensated by the decrease in error and variance.

We present an algorithm to extract features from high-dimensional gene expression profiles, based on the knowledge of a graph which links together genes known to participate to successive reactions in metabolic pathways. Motivated by the intuition that biologically relevant features are likely to exhibit smoothness with respect to the graph topology, the algorithm involves encoding the graph and the set of expression profiles into kernel functions, and performing a generalized form of canonical correlation analysis in the corresponding reproducible kernel Hilbert spaces. Function prediction experiments for the genes of the yeast S. Cerevisiae validate this approach by showing a consistent increase in performance when a state-of-the-art classifier uses the vector of features instead of the original expression profile to predict the functional class of a gene.